Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Terpenoid backbone biosynthesis (mmu00900)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
Acat1
KLA  Compactin  Compactin+KLA
 118130035 acetyl-Coenzyme A acetyltransferase 1 KLA0.990 1.040 0.990 0.950 1.030 0.910 0.970
Compactin1.040 1.040 0.960 0.990 1.100 0.980 1.050
KLA/Compactin1.010 1.040 0.960 0.950 0.980 1.040 0.970
Acat1
KLA  Compactin  Compactin+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA1.060 1.000 1.140 1.120 0.890 0.890 0.650
Compactin1.130 1.130 1.170 1.190 0.980 1.080 1.040
KLA/Compactin1.210 1.040 1.190 1.100 0.950 0.850 0.700
Acat2
KLA  Compactin  Compactin+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA0.990 0.960 0.940 1.000 0.740 0.880 0.980
Compactin0.990 1.060 1.190 1.150 1.100 1.090 0.920
KLA/Compactin0.940 1.030 1.020 1.020 0.870 0.880 0.960
Dhdds
KLA  Compactin  Compactin+KLA
 NM_026144 dehydrodolichyl diphosphate synthase (Dhdds), mRNA [NM_026144] KLA0.930 0.940 1.050 0.930 0.780 0.830 0.890
Compactin0.840 0.950 1.020 1.040 0.910 1.000 1.060
KLA/Compactin0.980 0.980 0.990 0.830 0.930 0.920 0.890
Dhdds
KLA  Compactin  Compactin+KLA
 NM_026144 dehydrodolichyl diphosphate synthase (Dhdds), mRNA [NM_026144] KLA1.310 1.170 1.270 1.180 1.190 1.410 1.460
Compactin1.210 1.410 1.140 1.090 1.080 0.970 1.050
KLA/Compactin1.200 1.080 1.160 1.280 1.280 1.270 1.430
Fdps
KLA  Compactin  Compactin+KLA
 AK077979 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030492I17 product:farnesyl diphosphate synthetase, full insert sequence. [AK077979] KLA1.030 0.760 0.500 0.410 0.630 0.720 0.550
Compactin0.900 1.030 1.180 0.880 1.080 0.990 1.140
KLA/Compactin0.980 0.840 0.610 0.590 0.730 0.580 0.650
Fdps
KLA  Compactin  Compactin+KLA
 NM_134469 farnesyl diphosphate synthetase (Fdps), mRNA [NM_134469] KLA0.980 0.850 0.850 0.750 0.720 0.700 0.800
Compactin0.890 0.860 0.920 0.860 1.190 1.220 1.050
KLA/Compactin0.890 0.870 0.880 0.850 0.990 0.900 1.140
Fnta
KLA  Compactin  Compactin+KLA
 NM_008033 farnesyltransferase, CAAX box, alpha (Fnta), mRNA [NM_008033] KLA0.910 0.970 1.010 1.110 1.030 1.110 1.070
Compactin1.040 1.060 1.030 1.180 0.990 1.120 1.200
KLA/Compactin0.980 1.000 1.020 1.120 1.160 1.180 1.110
Fntb
KLA  Compactin  Compactin+KLA
 NM_145927 farnesyltransferase, CAAX box, beta (Fntb), mRNA [NM_145927] KLA0.960 1.070 1.050 1.210 0.900 1.210 2.850
Compactin0.910 0.920 1.150 0.960 0.920 1.090 0.990
KLA/Compactin0.910 1.050 1.090 1.220 1.200 1.390 2.840
Fntb
KLA  Compactin  Compactin+KLA
 NM_145927 farnesyltransferase, CAAX box, beta (Fntb), mRNA [NM_145927] KLA1.080 1.040 1.060 1.040 0.900 0.900 1.050
Compactin1.140 1.070 1.030 1.100 0.990 0.990 0.980
KLA/Compactin1.050 1.120 0.980 0.970 0.950 0.880 1.000
Ggps1
KLA  Compactin  Compactin+KLA
 AK138564 adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330064P13 product:geranylgeranyl diphosphate synthase 1, full insert sequence [AK138564] KLA0.920 0.950 1.030 1.110 1.110 1.050 0.970
Compactin0.970 1.070 1.020 1.040 1.030 1.000 1.180
KLA/Compactin1.000 1.050 0.990 1.040 1.120 1.100 0.950
Ggps1
KLA  Compactin  Compactin+KLA
 NM_010282 geranylgeranyl diphosphate synthase 1 (Ggps1), mRNA [NM_010282] KLA0.950 1.110 1.130 1.340 1.510 1.620 2.060
Compactin1.020 1.090 1.090 1.020 0.890 0.900 1.000
KLA/Compactin0.990 1.180 1.040 1.310 1.480 1.480 1.770
Ggps1
KLA  Compactin  Compactin+KLA
 NM_010282 geranylgeranyl diphosphate synthase 1 (Ggps1), mRNA [NM_010282] KLA0.960 1.190 1.340 1.520 1.840 2.270 2.640
Compactin0.870 1.050 1.010 1.080 0.970 1.070 1.210
KLA/Compactin0.950 1.160 1.190 1.500 1.730 2.110 2.690
Hmgcr
KLA  Compactin  Compactin+KLA
 NM_008255 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA [NM_008255] KLA1.100 1.540 1.570 1.190 1.170 1.080 0.800
Compactin1.120 0.970 1.070 1.270 0.980 1.020 0.860
KLA/Compactin1.210 1.480 1.690 1.300 1.560 1.320 0.820
Hmgcr
KLA  Compactin  Compactin+KLA
 NM_008255 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA [NM_008255] KLA1.110 1.150 1.430 1.000 0.830 0.870 0.390
Compactin0.980 0.990 0.940 1.030 1.020 1.110 0.810
KLA/Compactin1.100 1.300 1.430 1.020 0.990 0.780 0.440
Hmgcr
KLA  Compactin  Compactin+KLA
 NM_008255 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA [NM_008255] KLA1.160 1.530 1.710 1.480 1.500 1.540 1.350
Compactin1.170 1.050 1.090 1.160 0.980 1.070 0.920
KLA/Compactin1.340 1.580 1.950 1.690 1.650 1.740 1.340
Hmgcr
KLA  Compactin  Compactin+KLA
 NM_008255 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA [NM_008255] KLA1.220 1.650 1.930 1.620 1.600 1.640 1.310
Compactin1.090 1.140 1.060 1.090 0.970 1.040 0.930
KLA/Compactin1.170 1.480 1.960 1.750 1.550 1.950 1.530
Hmgcs1
KLA  Compactin  Compactin+KLA
 AK078743 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030402P03 product:similar to hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) (fragment) [Gallus gallus], full insert sequence. [AK078743] KLA3.140 1.680 0.790 0.650 0.960 1.080 1.260
Compactin1.100 1.040 1.110 1.060 1.120 0.940 1.050
KLA/Compactin3.310 2.070 0.950 0.810 1.010 0.870 0.970
Hmgcs1
KLA  Compactin  Compactin+KLA
 NM_145942 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), mRNA [NM_145942] KLA0.940 1.360 1.370 0.850 0.960 0.930 0.940
Compactin1.010 0.940 0.970 1.110 0.990 0.960 0.920
KLA/Compactin1.030 1.190 1.530 0.950 1.190 1.130 1.070
Hmgcs1
KLA  Compactin  Compactin+KLA
 NM_145942 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), mRNA [NM_145942] KLA1.040 1.650 1.880 0.600 0.900 0.890 0.530
Compactin0.910 1.040 1.350 1.360 1.230 1.070 0.920
KLA/Compactin1.280 1.510 2.230 0.930 1.210 0.920 0.550
Hmgcs2
KLA  Compactin  Compactin+KLA
 NM_008256 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2), nuclear gene encoding mitochondrial protein, mRNA [NM_008256] KLA1.010 1.030 0.950 1.020 1.040 1.010 0.960
Compactin0.990 0.990 1.030 0.980 1.090 1.040 0.980
KLA/Compactin1.030 1.040 1.040 0.950 1.000 1.020 0.980
Icmt
KLA  Compactin  Compactin+KLA
 NM_133788 isoprenylcysteine carboxyl methyltransferase (Icmt), mRNA [NM_133788] KLA0.920 0.850 0.890 0.730 0.710 1.040 1.520
Compactin1.070 0.860 1.020 1.080 1.000 1.040 0.990
KLA/Compactin0.950 0.840 0.890 0.730 0.880 1.110 1.480
Idi1
KLA  Compactin  Compactin+KLA
 NM_177960 isopentenyl-diphosphate delta isomerase (Idi1), transcript variant 2, mRNA [NM_177960] KLA1.000 1.210 1.190 1.050 0.730 0.710 0.390
Compactin0.860 0.820 0.880 0.970 0.920 1.080 0.910
KLA/Compactin0.910 1.100 1.280 1.070 0.800 0.590 0.450
Idi1
KLA  Compactin  Compactin+KLA
 NM_177960 isopentenyl-diphosphate delta isomerase (Idi1), transcript variant 2, mRNA [NM_177960] KLA1.070 1.320 1.380 1.150 1.020 0.980 0.710
Compactin1.120 1.040 1.040 1.170 1.020 1.000 0.830
KLA/Compactin1.190 1.150 1.560 1.290 1.050 0.790 0.740
Idi2
KLA  Compactin  Compactin+KLA
 AK029364 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4833405L16 product:weakly similar to ISOPENTENYL PYROPHOSPHATE ISOMERASE TYPE 2 (CDNA FLJ32388 FIS, CLONE SKMUS1000129, MODERATELY SIMILAR TO ISOPENTENYL-DIPHOSPHATE DELTA KLA1.010 1.030 1.070 1.050 1.040 1.100 1.180
Compactin1.070 1.000 1.040 1.030 1.060 1.060 1.050
KLA/Compactin1.030 1.060 1.080 0.980 1.090 1.060 1.200
Mvd
KLA  Compactin  Compactin+KLA
 NM_138656 mevalonate (diphospho) decarboxylase (Mvd), mRNA [NM_138656] KLA1.070 1.010 0.930 0.600 0.600 0.820 0.820
Compactin1.350 1.120 1.180 1.540 1.520 1.160 0.890
KLA/Compactin1.170 0.980 1.140 0.840 0.850 0.840 0.840
Mvk
KLA  Compactin  Compactin+KLA
 NM_023556 mevalonate kinase (Mvk), mRNA [NM_023556] KLA1.060 1.010 1.050 0.870 0.840 1.040 1.010
Compactin1.200 1.060 1.130 1.310 1.190 1.070 0.880
KLA/Compactin1.340 1.050 0.990 0.890 0.930 1.030 1.090
Mvk
KLA  Compactin  Compactin+KLA
 NM_023556 mevalonate kinase (Mvk), mRNA [NM_023556] KLA1.260 1.090 1.040 0.990 0.850 0.930 0.970
Compactin1.230 1.130 1.230 1.390 1.150 1.150 0.900
KLA/Compactin1.170 1.030 1.040 1.070 1.030 0.890 1.100
Pcyox1
KLA  Compactin  Compactin+KLA
 NM_025823 prenylcysteine oxidase 1 (Pcyox1), mRNA [NM_025823] KLA0.800 0.730 0.650 0.500 0.580 0.650 0.950
Compactin0.950 0.920 1.020 1.090 1.040 0.940 0.900
KLA/Compactin0.950 0.740 0.610 0.500 0.650 0.790 0.820
Pdss1
KLA  Compactin  Compactin+KLA
 NM_019501 prenyl (solanesyl) diphosphate synthase, subunit 1 (Pdss1), mRNA [NM_019501] KLA0.910 0.950 1.070 1.230 0.810 0.770 0.760
Compactin0.920 0.850 0.990 1.070 1.000 1.060 1.000
KLA/Compactin0.900 0.940 1.030 1.140 1.060 0.770 0.730
Pdss1
KLA  Compactin  Compactin+KLA
 NM_019501 prenyl (solanesyl) diphosphate synthase, subunit 1 (Pdss1), mRNA [NM_019501] KLA1.070 1.030 1.180 1.180 0.990 0.880 0.710
Compactin1.140 1.020 1.270 1.200 1.130 1.180 1.100
KLA/Compactin1.160 1.030 1.160 1.280 1.000 0.750 0.680
Pdss2
KLA  Compactin  Compactin+KLA
 90568029 prenyl (solanesyl) diphosphate synthase, subunit 2 KLA1.050 1.190 1.110 1.190 0.990 0.940 0.780
Compactin1.110 1.140 1.010 1.170 0.950 1.060 0.990
KLA/Compactin1.080 1.150 1.090 1.150 1.020 0.920 0.740
Pdss2
KLA  Compactin  Compactin+KLA
 AK017329 6 days neonate head cDNA, RIKEN full-length enriched library, clone:5430420P03 product:weakly similar to CANDIDATE TUMOR SUPPRESSOR PROTEIN [Homo sapiens], full insert sequence. [AK017329] KLA0.900 1.040 0.990 0.880 0.990 1.060 0.950
Compactin0.930 1.020 0.960 1.020 0.990 0.980 1.070
KLA/Compactin0.950 0.980 0.840 1.060 0.980 0.960 1.030
Pmvk
KLA  Compactin  Compactin+KLA
 NM_026784 phosphomevalonate kinase (Pmvk), mRNA [NM_026784] KLA0.920 0.960 1.040 0.940 0.750 1.110 1.360
Compactin1.120 0.930 1.190 1.200 1.250 1.130 1.140
KLA/Compactin0.970 1.030 1.120 1.020 1.200 1.430 1.670
Pmvk
KLA  Compactin  Compactin+KLA
 NM_026784 phosphomevalonate kinase (Pmvk), mRNA [NM_026784] KLA0.990 0.990 1.000 0.800 0.990 1.060 1.110
Compactin0.910 1.070 1.020 1.110 1.230 1.000 1.230
KLA/Compactin0.970 1.000 1.170 0.940 1.080 1.270 1.550
Rce1
KLA  Compactin  Compactin+KLA
 NM_023131 RCE1 homolog, prenyl protein peptidase (S. cerevisiae) (Rce1), mRNA [NM_023131] KLA0.710 1.060 0.850 1.030 1.000 0.860 0.790
Compactin0.850 1.060 0.870 0.790 0.990 1.030 1.030
KLA/Compactin0.810 0.980 0.990 0.910 0.770 1.070 1.250
Rce1
KLA  Compactin  Compactin+KLA
 NM_023131 RCE1 homolog, prenyl protein peptidase (S. cerevisiae) (Rce1), mRNA [NM_023131] KLA0.940 0.910 0.950 0.960 0.920 0.840 0.850
Compactin0.930 0.950 0.980 0.900 0.920 1.050 1.040
KLA/Compactin0.860 1.000 1.010 0.900 0.860 0.870 0.980
Zmpste24
KLA  Compactin  Compactin+KLA
 AK079998 adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530043O15 product:inferred: CAAX PRENYL PROTEASE 1 HOMOLOG (EC 3.4.24.-) (PRENYL PROTEIN-SPECIFIC ENDOPROTEASE 1). [Human] {Homo, full insert sequence [AK079998] KLA0.960 1.110 1.190 1.200 1.010 1.090 1.430
Compactin1.000 0.980 0.990 0.990 0.920 0.950 1.000
KLA/Compactin1.050 1.100 1.220 1.150 1.180 1.340 1.630
Zmpste24
KLA  Compactin  Compactin+KLA
 NM_172700 zinc metallopeptidase, STE24 homolog (S. cerevisiae) (Zmpste24), mRNA [NM_172700] KLA0.820 0.960 0.730 0.970 1.050 0.890 0.730
Compactin0.930 1.020 0.820 0.890 0.940 1.240 1.140
KLA/Compactin1.100 0.930 0.820 1.030 0.790 0.800 1.030