Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Propanoate metabolism (mmu00640)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
Abat
KLA  Compactin  Compactin+KLA
 AK083062 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530041H11 product:hypothetical protein, full insert sequence. [AK083062] KLA1.000 0.960 1.000 1.000 1.050 0.950 1.020
Compactin1.070 1.010 1.010 1.000 1.010 1.010 0.980
KLA/Compactin1.010 1.020 1.030 1.010 1.020 0.990 1.070
Abat
KLA  Compactin  Compactin+KLA
 NM_172961 4-aminobutyrate aminotransferase (Abat), nuclear gene encoding mitochondrial protein, mRNA [NM_172961] KLA0.980 1.020 1.000 0.950 1.010 0.960 1.030
Compactin0.990 1.020 0.950 1.060 1.030 1.020 0.990
KLA/Compactin1.020 0.980 0.990 0.950 1.000 0.990 0.990
Acaca
KLA  Compactin  Compactin+KLA
 NM_133360 acetyl-Coenzyme A carboxylase alpha (Acaca), mRNA [NM_133360] KLA0.930 1.050 1.000 1.010 0.940 0.990 0.990
Compactin1.050 1.020 1.010 1.030 1.060 0.980 0.980
KLA/Compactin1.050 1.070 0.940 1.010 0.970 0.990 0.980
Acaca
KLA  Compactin  Compactin+KLA
 NM_133360 acetyl-Coenzyme A carboxylase alpha (Acaca), mRNA [NM_133360] KLA1.120 1.080 1.020 0.980 0.960 1.040 1.070
Compactin1.070 1.010 0.960 0.980 1.100 1.010 1.040
KLA/Compactin1.050 1.030 0.960 1.010 0.950 0.980 1.090
Acacb
KLA  Compactin  Compactin+KLA
 NM_133904 acetyl-Coenzyme A carboxylase beta (Acacb), mRNA [NM_133904] KLA1.030 1.080 0.970 0.960 0.920 0.980 0.950
Compactin1.020 1.020 1.060 0.980 1.030 1.050 1.000
KLA/Compactin1.160 0.930 1.030 0.990 0.930 0.950 0.950
Acadm
KLA  Compactin  Compactin+KLA
 NM_007382 acyl-Coenzyme A dehydrogenase, medium chain (Acadm), nuclear gene encoding mitochondrial protein, mRNA [NM_007382] KLA0.980 0.830 0.580 0.570 0.770 0.630 0.420
Compactin0.940 0.970 1.020 0.780 1.060 1.260 1.140
KLA/Compactin0.850 0.900 0.840 0.550 0.610 0.700 0.650
Acat1
KLA  Compactin  Compactin+KLA
 118130035 acetyl-Coenzyme A acetyltransferase 1 KLA0.990 1.040 0.990 0.950 1.030 0.910 0.970
Compactin1.040 1.040 0.960 0.990 1.100 0.980 1.050
KLA/Compactin1.010 1.040 0.960 0.950 0.980 1.040 0.970
Acat1
KLA  Compactin  Compactin+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA1.060 1.000 1.140 1.120 0.890 0.890 0.650
Compactin1.130 1.130 1.170 1.190 0.980 1.080 1.040
KLA/Compactin1.210 1.040 1.190 1.100 0.950 0.850 0.700
Acat2
KLA  Compactin  Compactin+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA0.990 0.960 0.940 1.000 0.740 0.880 0.980
Compactin0.990 1.060 1.190 1.150 1.100 1.090 0.920
KLA/Compactin0.940 1.030 1.020 1.020 0.870 0.880 0.960
Acss1
KLA  Compactin  Compactin+KLA
 NM_080575 acyl-CoA synthetase short-chain family member 1 (Acss1), nuclear gene encoding mitochondrial protein, mRNA [NM_080575] KLA0.910 0.970 0.770 0.810 0.640 0.500 0.330
Compactin0.960 1.000 0.890 0.940 0.970 0.820 0.570
KLA/Compactin0.850 0.950 0.810 0.760 0.560 0.450 0.290
Acss2
KLA  Compactin  Compactin+KLA
 AK003738 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110017C11 product:acetyl-Coenzyme A synthetase 1 (AMP forming), full insert sequence. [AK003738] KLA0.880 1.030 0.900 0.990 0.940 1.010 1.810
Compactin1.040 1.050 0.960 0.990 0.990 1.010 1.050
KLA/Compactin0.980 1.020 0.890 1.000 0.950 1.280 2.200
Acss2
KLA  Compactin  Compactin+KLA
 NM_019811 acyl-CoA synthetase short-chain family member 2 (Acss2), mRNA [NM_019811] KLA0.760 0.860 0.660 0.730 0.740 0.850 1.300
Compactin0.850 0.940 0.960 0.830 1.160 1.250 0.760
KLA/Compactin0.990 0.810 0.900 0.670 0.780 1.120 2.150
Acss2
KLA  Compactin  Compactin+KLA
 NM_019811 acyl-CoA synthetase short-chain family member 2 (Acss2), mRNA [NM_019811] KLA0.950 0.930 0.920 0.900 0.800 0.950 1.470
Compactin0.930 0.870 1.060 1.010 1.230 1.200 0.830
KLA/Compactin1.090 0.870 0.970 0.860 0.850 1.100 1.710
Acss3
KLA  Compactin  Compactin+KLA
 NM_198636 acyl-CoA synthetase short-chain family member 3 (Acss3), mRNA [NM_198636] KLA1.050 1.060 0.960 0.970 0.940 0.970 0.960
Compactin1.110 0.990 1.090 1.050 1.040 0.990 0.990
KLA/Compactin0.940 0.920 1.020 0.990 0.930 1.030 1.010
Aldh1b1
KLA  Compactin  Compactin+KLA
 NM_028270 aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270] KLA0.990 0.930 1.090 2.540 4.350 5.420 5.340
Compactin1.030 0.980 1.040 1.190 0.880 0.810 1.090
KLA/Compactin0.970 0.900 1.030 2.940 5.190 6.900 5.710
Aldh2
KLA  Compactin  Compactin+KLA
 AK163452 adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452] KLA0.980 1.050 1.010 0.980 1.000 1.030 1.060
Compactin1.050 1.010 1.010 1.030 1.070 1.030 0.970
KLA/Compactin0.990 1.000 1.030 0.950 1.030 0.960 1.050
Aldh2
KLA  Compactin  Compactin+KLA
 NM_009656 aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656] KLA0.940 0.930 0.960 0.980 0.830 0.900 0.880
Compactin1.080 0.910 0.930 1.150 1.580 1.000 0.840
KLA/Compactin1.050 1.030 1.050 0.790 1.020 0.880 0.860
Aldh3a2
KLA  Compactin  Compactin+KLA
 NM_007437 aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437] KLA1.040 0.900 0.840 0.840 1.130 1.330 1.150
Compactin1.020 1.070 0.990 1.170 1.000 0.960 1.110
KLA/Compactin1.110 0.870 0.880 0.930 1.320 1.440 1.120
Aldh6a1
KLA  Compactin  Compactin+KLA
 NM_134042 aldehyde dehydrogenase family 6, subfamily A1 (Aldh6a1), nuclear gene encoding mitochondrial protein, mRNA [NM_134042] KLA0.950 0.950 0.840 0.760 0.860 1.260 1.960
Compactin0.940 1.020 1.000 1.100 1.120 0.940 1.080
KLA/Compactin0.950 0.900 0.910 0.820 1.010 1.650 2.190
Aldh7a1
KLA  Compactin  Compactin+KLA
 NM_138600 aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600] KLA0.970 0.980 0.980 1.060 1.020 1.080 1.220
Compactin1.000 1.070 0.990 1.010 0.950 0.980 0.990
KLA/Compactin1.000 1.020 1.010 1.150 1.070 1.060 1.260
Aldh7a1
KLA  Compactin  Compactin+KLA
 NM_138600 aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600] KLA1.000 0.990 1.000 1.070 1.060 1.000 1.010
Compactin0.990 0.950 1.010 0.990 0.970 0.950 1.000
KLA/Compactin1.060 1.010 0.990 0.990 0.920 1.020 0.960
Aldh9a1
KLA  Compactin  Compactin+KLA
 NM_019993 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993] KLA0.900 0.880 0.920 0.850 0.780 0.700 0.750
Compactin0.890 0.960 0.920 0.920 1.080 1.090 0.980
KLA/Compactin0.840 0.950 0.950 0.850 0.750 0.710 0.870
Aldh9a1
KLA  Compactin  Compactin+KLA
 NM_019993 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993] KLA0.930 0.840 0.770 0.830 0.740 0.590 0.640
Compactin0.870 0.870 0.910 0.930 0.990 0.980 0.980
KLA/Compactin0.890 0.960 0.890 0.710 0.660 0.600 0.630
Aldh9a1
KLA  Compactin  Compactin+KLA
 NM_019993 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993] KLA1.020 0.950 0.990 0.900 0.680 0.660 0.630
Compactin1.180 1.040 1.120 1.230 1.070 1.030 0.960
KLA/Compactin1.110 0.940 1.000 0.880 0.670 0.650 0.700
Echs1
KLA  Compactin  Compactin+KLA
 NM_053119 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (Echs1), nuclear gene encoding mitochondrial protein, mRNA [NM_053119] KLA0.970 0.920 0.850 0.710 0.930 1.420 1.610
Compactin0.910 1.040 1.190 1.140 0.930 0.950 1.210
KLA/Compactin0.880 0.880 1.030 0.850 0.870 1.240 1.000
Ehhadh
KLA  Compactin  Compactin+KLA
 NM_023737 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (Ehhadh), mRNA [NM_023737] KLA0.980 0.990 0.920 0.970 0.940 1.010 0.990
Compactin1.000 1.000 1.010 1.000 0.940 0.960 0.960
KLA/Compactin1.030 0.920 1.010 1.010 0.980 1.050 1.000
Hadha
KLA  Compactin  Compactin+KLA
 AK050856 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA0.890 1.000 1.070 0.990 1.030 1.070 0.900
Compactin1.060 1.020 0.980 0.990 1.070 0.990 0.980
KLA/Compactin0.960 1.060 0.990 1.060 1.000 0.970 0.920
Hadha
KLA  Compactin  Compactin+KLA
 NM_178878 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA1.060 0.930 0.900 1.160 1.030 1.080 1.510
Compactin1.080 0.950 0.940 0.940 1.050 1.070 0.920
KLA/Compactin0.950 1.020 0.940 0.980 1.080 1.210 1.590
Hibch
KLA  Compactin  Compactin+KLA
 NM_146108 3-hydroxyisobutyryl-Coenzyme A hydrolase (Hibch), mRNA [NM_146108] KLA1.050 1.100 1.080 0.870 0.870 1.190 1.370
Compactin1.010 1.130 1.240 1.030 0.990 0.990 0.960
KLA/Compactin0.940 1.140 1.110 0.920 0.830 1.380 1.380
Ldha
KLA  Compactin  Compactin+KLA
 NM_010699 lactate dehydrogenase A (Ldha), mRNA [NM_010699] KLA0.860 1.040 0.690 0.970 1.170 0.830 0.750
Compactin0.790 1.100 1.010 1.020 1.160 1.110 0.970
KLA/Compactin0.870 1.020 0.830 0.960 0.850 0.830 1.070
Ldha
KLA  Compactin  Compactin+KLA
 NM_010699 lactate dehydrogenase A (Ldha), mRNA [NM_010699] KLA1.090 0.980 0.830 0.930 1.150 0.840 0.700
Compactin0.980 1.090 0.960 0.890 1.100 1.290 0.930
KLA/Compactin0.880 0.990 0.930 0.960 0.760 0.790 1.070
Ldhal6b
KLA  Compactin  Compactin+KLA
 NM_175349 lactate dehydrogenase A-like 6B (Ldhal6b), mRNA [NM_175349] KLA0.970 0.990 1.000 1.010 1.110 1.160 1.290
Compactin1.110 0.980 1.000 1.030 1.020 1.020 1.160
KLA/Compactin0.960 0.930 0.970 1.040 1.150 1.190 1.260
Ldhb
KLA  Compactin  Compactin+KLA
 NM_008492 lactate dehydrogenase B (Ldhb), mRNA [NM_008492] KLA1.010 0.950 1.010 1.040 1.020 0.980 1.020
Compactin1.020 0.950 1.070 0.980 0.990 1.040 0.990
KLA/Compactin1.020 1.050 1.000 0.990 1.010 1.000 0.960
Ldhc
KLA  Compactin  Compactin+KLA
 NM_013580 lactate dehydrogenase C (Ldhc), mRNA [NM_013580] KLA1.060 1.020 1.070 1.020 1.000 1.030 0.980
Compactin1.060 1.020 0.950 1.060 0.950 1.040 1.040
KLA/Compactin0.910 1.010 0.980 1.100 1.030 1.020 0.930
Mcee
KLA  Compactin  Compactin+KLA
 NM_028626 methylmalonyl CoA epimerase (Mcee), mRNA [NM_028626] KLA0.960 0.990 0.880 0.990 0.820 0.830 1.200
Compactin0.990 1.090 1.080 0.990 0.990 0.870 0.850
KLA/Compactin0.920 0.870 0.960 1.020 0.820 0.890 1.190
Mlycd
KLA  Compactin  Compactin+KLA
 NM_019966 malonyl-CoA decarboxylase (Mlycd), nuclear gene encoding mitochondrial protein, mRNA [NM_019966] KLA0.810 0.770 0.660 0.650 0.600 0.730 0.670
Compactin0.870 0.960 0.900 1.020 0.930 0.970 0.900
KLA/Compactin0.960 0.890 0.630 0.580 0.810 0.720 0.530
Mut
KLA  Compactin  Compactin+KLA
 X51941 gb|Mouse mRNA for methylmalonyl CoA mutase (EC 5.4.99.2) [X51941] KLA0.940 0.880 0.700 0.840 0.750 0.570 0.580
Compactin0.950 0.860 0.760 0.890 0.870 1.040 0.770
KLA/Compactin0.820 0.840 0.740 0.670 0.590 0.640 0.610
Mut
KLA  Compactin  Compactin+KLA
 X51941 gb|Mouse mRNA for methylmalonyl CoA mutase (EC 5.4.99.2) [X51941] KLA0.970 0.920 0.920 0.760 0.620 0.730 0.560
Compactin1.020 1.060 1.060 1.130 0.860 0.930 0.860
KLA/Compactin1.080 0.960 0.860 0.790 0.700 0.790 0.460
Mut
KLA  Compactin  Compactin+KLA
 X51941 gb|Mouse mRNA for methylmalonyl CoA mutase (EC 5.4.99.2) [X51941] KLA0.990 0.910 0.930 0.650 0.570 0.740 0.600
Compactin1.120 0.910 1.040 1.080 0.910 1.030 0.800
KLA/Compactin1.150 0.890 0.930 0.830 0.610 0.660 0.540
Pcca
KLA  Compactin  Compactin+KLA
 NM_144844 propionyl-Coenzyme A carboxylase, alpha polypeptide (Pcca), mRNA [NM_144844] KLA1.120 1.010 1.190 1.110 0.920 0.910 1.470
Compactin1.140 1.140 1.140 1.150 1.050 1.080 0.890
KLA/Compactin1.140 1.040 1.100 1.130 0.860 0.900 1.380
Pccb
KLA  Compactin  Compactin+KLA
 NM_025835 propionyl Coenzyme A carboxylase, beta polypeptide (Pccb), mRNA [NM_025835] KLA0.970 0.970 0.980 0.900 0.810 0.740 0.730
Compactin1.070 1.030 1.020 1.080 0.990 0.990 0.810
KLA/Compactin1.020 0.960 0.990 0.990 0.790 0.750 0.720
Sucla2
KLA  Compactin  Compactin+KLA
 AK016060 adult male testis cDNA, RIKEN full-length enriched library, clone:4930547K18 product:unclassifiable, full insert sequence. [AK016060] KLA1.000 1.050 1.060 1.060 0.990 1.030 1.000
Compactin1.040 1.020 1.060 0.980 1.030 1.020 1.030
KLA/Compactin1.000 0.990 1.030 1.020 1.020 1.010 1.050
Sucla2
KLA  Compactin  Compactin+KLA
 NM_011506 succinate-Coenzyme A ligase, ADP-forming, beta subunit (Sucla2), nuclear gene encoding mitochondrial protein, mRNA [NM_011506] KLA0.800 0.870 0.760 0.970 0.840 0.660 0.430
Compactin0.810 1.000 1.060 0.780 1.000 1.000 0.840
KLA/Compactin0.970 0.910 0.960 0.850 0.760 0.660 0.460
Sucla2
KLA  Compactin  Compactin+KLA
 NM_011506 succinate-Coenzyme A ligase, ADP-forming, beta subunit (Sucla2), nuclear gene encoding mitochondrial protein, mRNA [NM_011506] KLA1.070 1.070 1.110 1.050 1.100 1.050 1.220
Compactin1.020 1.200 1.160 1.230 1.050 1.140 0.960
KLA/Compactin1.050 1.050 1.050 1.030 1.090 1.140 1.270
Suclg1
KLA  Compactin  Compactin+KLA
 NM_019879 succinate-CoA ligase, GDP-forming, alpha subunit (Suclg1), mRNA [NM_019879] KLA0.790 0.890 0.700 0.810 1.060 0.810 0.890
Compactin0.820 0.940 0.960 0.790 1.060 1.210 0.880
KLA/Compactin0.860 0.910 0.890 0.890 0.770 0.750 1.080
Suclg2
KLA  Compactin  Compactin+KLA
 NM_011507 succinate-Coenzyme A ligase, GDP-forming, beta subunit (Suclg2), mRNA [NM_011507] KLA0.930 0.960 1.120 0.880 0.770 0.720 0.710
Compactin0.960 0.930 0.960 1.050 1.050 0.960 0.690
KLA/Compactin0.990 1.070 1.180 0.830 0.800 0.720 0.620
Suclg2
KLA  Compactin  Compactin+KLA
 NM_011507 succinate-Coenzyme A ligase, GDP-forming, beta subunit (Suclg2), mRNA [NM_011507] KLA1.110 1.100 1.140 1.180 0.860 0.780 0.730
Compactin1.140 1.080 1.170 1.280 1.120 0.980 0.800
KLA/Compactin1.080 1.130 1.160 1.150 0.860 0.630 0.590