Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

Kdo₂-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Selenocompound metabolism (mmu00450)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	30min	1hr	2hr	4hr	8hr	12hr	24hr
BB135800	KLA  Compactin  Compactin+KLA	BB135800	gb|BB135800 RIKEN full-length enriched, adult male bone Mus musculus cDNA clone 9830130K22 3. [BB135800]	KLA	1.050	0.780	0.750	0.740	1.090	1.250	0.850
				Compactin	1.070	1.060	1.060	0.940	0.970	0.800	0.790
				KLA/Compactin	1.160	0.760	0.750	0.820	0.870	0.830	0.770
Ccbl1	KLA  Compactin  Compactin+KLA	NM_172404	cysteine conjugate-beta lyase 1 (Ccbl1), mRNA [NM_172404]	KLA	0.940	1.010	0.920	0.800	0.700	0.870	1.280
				Compactin	0.920	1.030	1.060	1.010	1.070	1.050	1.210
				KLA/Compactin	0.940	1.000	0.860	0.800	0.740	0.910	1.250
Ccbl2	KLA  Compactin  Compactin+KLA	NM_173763	cysteine conjugate-beta lyase 2 (Ccbl2), mRNA [NM_173763]	KLA	0.890	0.950	0.970	1.140	0.780	0.770	0.830
				Compactin	0.940	0.890	0.980	1.150	1.030	0.940	0.770
				KLA/Compactin	1.000	1.060	0.860	1.070	0.890	0.720	0.680
Cth	KLA  Compactin  Compactin+KLA	NM_145953	cystathionase (cystathionine gamma-lyase) (Cth), mRNA [NM_145953]	KLA	0.850	1.000	1.070	1.550	4.440	4.630	3.370
				Compactin	0.890	0.930	0.970	0.880	1.080	0.770	1.620
				KLA/Compactin	0.850	0.910	0.950	1.640	4.490	6.310	3.500
Cth	KLA  Compactin  Compactin+KLA	NM_145953	cystathionase (cystathionine gamma-lyase) (Cth), mRNA [NM_145953]	KLA	0.940	1.030	0.840	1.770	5.110	5.210	3.830
				Compactin	0.870	1.030	1.040	0.980	1.020	0.940	1.720
				KLA/Compactin	0.910	0.980	1.130	1.900	3.350	5.770	4.000
Inmt	KLA  Compactin  Compactin+KLA	NM_009349	indolethylamine N-methyltransferase (Inmt), mRNA [NM_009349]	KLA	1.070	1.050	1.030	1.010	0.970	1.000	0.890
				Compactin	1.020	1.000	0.900	0.970	1.080	1.000	0.970
				KLA/Compactin	0.970	1.060	1.170	1.080	0.930	0.890	0.910
Mars	KLA  Compactin  Compactin+KLA	51491851	methionine-tRNA synthetase	KLA	1.070	1.030	1.230	0.880	0.790	1.010	1.020
				Compactin	1.200	1.290	1.100	1.210	1.020	0.990	0.980
				KLA/Compactin	1.170	1.000	0.940	1.080	1.040	0.940	1.020
Mars	KLA  Compactin  Compactin+KLA	NM_001003913	methionine-tRNA synthetase (Mars), mRNA [NM_001003913]	KLA	0.970	0.910	0.990	0.950	0.790	0.940	1.120
				Compactin	1.180	0.970	1.020	1.140	1.260	0.920	0.970
				KLA/Compactin	1.150	1.060	0.970	0.970	0.880	1.100	1.100
Mars2	KLA  Compactin  Compactin+KLA	NM_175439	methionine-tRNA synthetase 2 (mitochondrial) (Mars2), nuclear gene encoding mitochondrial protein, mRNA [NM_175439]	KLA	0.940	0.910	0.980	0.960	0.730	0.730	0.670
				Compactin	1.050	0.910	0.930	0.920	1.070	0.990	0.910
				KLA/Compactin	0.930	0.920	0.870	0.850	0.760	0.650	0.670
Mars2	KLA  Compactin  Compactin+KLA	NM_175439	methionine-tRNA synthetase 2 (mitochondrial) (Mars2), nuclear gene encoding mitochondrial protein, mRNA [NM_175439]	KLA	1.000	0.960	1.020	0.920	0.870	0.770	0.690
				Compactin	1.100	1.040	0.990	1.050	0.950	1.040	0.930
				KLA/Compactin	0.990	0.900	0.900	0.900	0.850	0.740	0.600
Mtr	KLA  Compactin  Compactin+KLA	AK037599	16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130029B16 product:5-methyltetrahydrofolate-homocysteine methyltransferase, full insert sequence. [AK037599]	KLA	1.040	0.990	1.050	0.860	0.800	0.880	0.800
				Compactin	1.090	1.040	1.030	1.080	0.930	0.930	0.820
				KLA/Compactin	1.120	1.020	0.960	0.900	0.780	0.760	0.800
Mtr	KLA  Compactin  Compactin+KLA	NM_001081128	5-methyltetrahydrofolate-homocysteine methyltransferase (Mtr), mRNA [NM_001081128]	KLA	0.780	0.960	0.840	0.810	0.870	0.660	0.820
				Compactin	0.910	0.780	0.820	0.710	0.960	1.110	0.860
				KLA/Compactin	0.810	1.000	0.930	0.800	0.560	0.570	0.840
Mtr	KLA  Compactin  Compactin+KLA	NM_001081128	5-methyltetrahydrofolate-homocysteine methyltransferase (Mtr), mRNA [NM_001081128]	KLA	0.850	0.990	0.840	0.930	0.920	0.660	0.700
				Compactin	0.930	0.910	0.890	0.770	0.980	1.120	0.760
				KLA/Compactin	1.010	1.060	0.960	0.790	0.640	0.620	0.820
Papss1	KLA  Compactin  Compactin+KLA	NM_011863	3-phosphoadenosine 5-phosphosulfate synthase 1 (Papss1), mRNA [NM_011863]	KLA	1.120	1.100	1.050	0.910	0.760	0.770	0.900
				Compactin	1.230	1.190	1.150	1.260	1.120	1.030	0.880
				KLA/Compactin	1.100	1.120	1.000	1.000	0.970	0.820	1.060
Papss2	KLA  Compactin  Compactin+KLA	AK029185	0 day neonate head cDNA, RIKEN full-length enriched library, clone:4831410G12 product:3-phosphoadenosine 5-phosphosulfate synthase 2, full insert sequence. [AK029185]	KLA	1.010	1.020	0.970	1.000	0.990	0.980	0.990
				Compactin	0.970	0.910	0.970	1.000	1.080	0.970	0.990
				KLA/Compactin	0.990	1.030	1.000	1.020	1.050	1.070	0.940
Papss2	KLA  Compactin  Compactin+KLA	NM_011864	3-phosphoadenosine 5-phosphosulfate synthase 2 (Papss2), mRNA [NM_011864]	KLA	1.060	0.930	0.940	0.970	1.020	1.010	0.990
				Compactin	1.070	1.010	1.000	1.000	1.080	1.080	0.920
				KLA/Compactin	0.930	1.060	1.070	1.050	0.990	1.060	1.080
Pstk	KLA  Compactin  Compactin+KLA	AK017332	6 days neonate head cDNA, RIKEN full-length enriched library, clone:5430423O14 product:unclassifiable, full insert sequence. [AK017332]	KLA	0.690	0.750	0.790	0.690	0.820	0.940	0.780
				Compactin	1.050	1.040	0.970	0.940	1.140	0.930	1.140
				KLA/Compactin	0.840	0.610	0.890	0.630	0.820	0.790	0.660
Pstk	KLA  Compactin  Compactin+KLA	NM_001039534	phosphoseryl-tRNA kinase (Pstk), mRNA [NM_001039534]	KLA	1.120	1.100	0.860	0.780	0.690	0.890	0.950
				Compactin	1.060	1.150	1.120	1.200	1.200	0.970	1.200
				KLA/Compactin	1.000	0.840	1.030	0.820	0.630	0.810	1.070
Scly	KLA  Compactin  Compactin+KLA	NM_016717	selenocysteine lyase (Scly), mRNA [NM_016717]	KLA	0.740	0.860	0.620	0.710	0.800	0.780	0.780
				Compactin	0.830	1.010	0.840	0.680	0.890	0.710	0.520
				KLA/Compactin	0.820	0.940	0.740	0.650	0.510	0.670	0.790
Sephs1	KLA  Compactin  Compactin+KLA	NM_175400	selenophosphate synthetase 1 (Sephs1), mRNA [NM_175400]	KLA	0.980	1.070	1.040	0.940	0.930	0.960	0.940
				Compactin	1.070	1.010	1.030	1.010	0.910	0.990	1.050
				KLA/Compactin	1.050	0.900	1.000	1.040	0.940	0.910	0.860
Sephs1	KLA  Compactin  Compactin+KLA	NM_175400	selenophosphate synthetase 1 (Sephs1), mRNA [NM_175400]	KLA	1.080	1.040	0.990	0.900	0.790	0.880	0.970
				Compactin	1.280	1.110	1.070	1.120	1.020	0.960	0.820
				KLA/Compactin	1.160	1.080	1.000	0.920	0.770	0.770	0.900
Sephs2	KLA  Compactin  Compactin+KLA	NM_009266	selenophosphate synthetase 2 (Sephs2), mRNA [NM_009266]	KLA	1.040	0.970	0.870	0.700	0.740	0.670	0.550
				Compactin	1.090	1.140	1.050	1.080	1.060	0.920	0.840
				KLA/Compactin	1.040	0.990	0.770	0.680	0.870	0.730	0.450
Sepsecs	KLA  Compactin  Compactin+KLA	AK088165	2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430005G07 product:unclassifiable, full insert sequence. [AK088165]	KLA	0.990	1.060	1.150	1.570	1.280	1.200	1.230
				Compactin	1.100	1.100	1.000	1.330	1.280	1.160	1.340
				KLA/Compactin	1.000	1.010	0.940	1.340	1.540	1.280	1.260
Sepsecs	KLA  Compactin  Compactin+KLA	NM_172490	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase (Sepsecs), mRNA [NM_172490]	KLA	1.000	1.060	1.240	1.220	1.170	1.430	1.490
				Compactin	0.970	0.970	0.950	0.910	0.990	1.040	1.090
				KLA/Compactin	0.940	1.090	1.210	1.130	1.410	1.390	1.280
Txnrd1	KLA  Compactin  Compactin+KLA	NM_001042523	thioredoxin reductase 1 (Txnrd1), transcript variant 1, mRNA [NM_001042523]	KLA	1.430	1.820	1.890	1.680	1.860	1.360	1.590
				Compactin	1.320	1.220	1.260	1.320	1.080	1.010	1.110
				KLA/Compactin	1.420	1.440	1.990	1.730	1.710	1.500	1.560
Txnrd2	KLA  Compactin  Compactin+KLA	AK008004	adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010001F03 product:ADULT MALE SMALL INTESTINE CDNA, RIKEN FULL-LENGTH ENRICHED LIBRARY, CLONE:2010001F03, FULL INSERT SEQUENCE, full insert sequence. [AK008004]	KLA	1.220	1.420	1.610	1.960	1.210	1.200	1.500
				Compactin	1.010	1.050	1.080	1.230	1.110	0.980	0.990
				KLA/Compactin	1.270	1.760	1.450	2.130	1.250	1.380	1.470
Txnrd2	KLA  Compactin  Compactin+KLA	NM_013711	thioredoxin reductase 2 (Txnrd2), nuclear gene encoding mitochondrial protein, mRNA [NM_013711]	KLA	0.870	0.780	0.800	0.810	0.840	0.840	0.940
				Compactin	0.920	0.930	0.870	0.810	0.890	1.040	1.010
				KLA/Compactin	0.690	0.920	0.850	0.910	0.710	0.850	1.180
Txnrd2	KLA  Compactin  Compactin+KLA	NM_013711	thioredoxin reductase 2 (Txnrd2), nuclear gene encoding mitochondrial protein, mRNA [NM_013711]	KLA	0.910	0.960	0.960	0.990	0.760	0.750	0.940
				Compactin	0.980	0.950	0.890	0.900	1.020	0.960	0.870
				KLA/Compactin	0.900	1.090	0.950	0.830	0.720	0.790	0.970
Txnrd3	KLA  Compactin  Compactin+KLA	NM_153162	thioredoxin reductase 3 (Txnrd3), mRNA [NM_153162]	KLA	1.100	1.070	1.140	0.930	0.910	0.980	0.800
				Compactin	1.180	1.140	1.070	1.140	1.040	0.980	1.080
				KLA/Compactin	1.110	1.100	1.180	1.020	0.990	0.780	0.680