Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

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Kdo₂-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Caffeine metabolism (mmu00232)

Legend:	: View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	30min	1hr	2hr	4hr	8hr	12hr	24hr
Cyp1a2	KLA Compactin Compactin+KLA	NM_009993	cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2), mRNA [NM_009993]	KLA	1.040	1.050	0.990	0.940	1.020	0.960	0.990
				Compactin	1.020	1.050	1.010	1.000	1.030	1.060	0.990
				KLA/Compactin	1.010	0.990	1.120	1.020	1.000	1.040	0.980

Cyp1a2	KLA Compactin Compactin+KLA	NM_009993		cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2), mRNA [NM_009993]	KLA	1.060	0.970	0.980	0.980	0.990	1.010	1.020
					Compactin	0.980	1.050	1.020	0.960	1.010	1.030	0.980
					KLA/Compactin	0.980	1.000	0.940	0.990	1.030	0.980	1.070

Cyp2a12	KLA Compactin Compactin+KLA	NM_133657	cytochrome P450, family 2, subfamily a, polypeptide 12 (Cyp2a12), mRNA [NM_133657]	KLA	0.920	0.990	1.000	0.940	0.920	1.070	1.000
				Compactin	0.920	0.960	1.010	0.980	0.950	1.000	0.990
				KLA/Compactin	1.040	0.950	0.960	0.990	1.000	0.940	0.980

Cyp2a4	KLA Compactin Compactin+KLA	116268117		cytochrome P450, family 2, subfamily a, polypeptide 4	KLA	1.020	0.950	0.960	0.950	1.020	1.050	0.970
					Compactin	0.870	1.020	1.040	0.960	0.940	1.010	0.990
					KLA/Compactin	0.930	0.990	1.010	1.050	1.000	0.900	0.990

Cyp2a4	KLA Compactin Compactin+KLA	NM_009997	cytochrome P450, family 2, subfamily a, polypeptide 4 (Cyp2a4), mRNA [NM_009997]	KLA	1.040	0.920	0.960	1.040	0.970	0.980	1.110
				Compactin	0.970	0.970	0.930	0.980	1.020	1.020	0.900
				KLA/Compactin	0.960	1.020	0.980	1.000	1.030	0.990	0.950

Cyp2a4	KLA Compactin Compactin+KLA	NM_009997		cytochrome P450, family 2, subfamily a, polypeptide 4 (Cyp2a4), mRNA [NM_009997]	KLA	0.940	1.030	0.990	0.980	1.040	0.970	1.070
					Compactin	1.050	1.050	0.970	0.920	1.020	1.010	1.010
					KLA/Compactin	1.020	1.000	0.990	0.990	1.050	1.040	1.060

Cyp2a4	KLA Compactin Compactin+KLA	NM_009997	cytochrome P450, family 2, subfamily a, polypeptide 4 (Cyp2a4), mRNA [NM_009997]	KLA	0.990	1.060	1.010	0.910	0.960	1.020	0.990
				Compactin	0.940	0.940	0.950	1.000	0.940	1.020	1.020
				KLA/Compactin	0.960	1.020	0.930	1.060	0.910	0.960	1.050

Cyp2a5	KLA Compactin Compactin+KLA	NM_007812		cytochrome P450, family 2, subfamily a, polypeptide 5 (Cyp2a5), mRNA [NM_007812]	KLA	0.940	1.020	0.970	0.920	0.950	1.100	1.030
					Compactin	0.890	0.990	1.000	1.000	0.880	0.970	1.110
					KLA/Compactin	0.980	0.910	0.990	1.040	1.000	0.900	1.060

Nat1	KLA Compactin Compactin+KLA	NM_008673	N-acetyltransferase 1 (arylamine N-acetyltransferase) (Nat1), mRNA [NM_008673]	KLA	0.980	1.020	1.030	0.960	0.980	1.050	0.960
				Compactin	0.980	0.980	1.040	0.980	0.920	1.000	1.070
				KLA/Compactin	0.950	1.000	1.010	1.020	0.970	0.970	1.060

Nat2	KLA Compactin Compactin+KLA	NM_010874		N-acetyltransferase 2 (arylamine N-acetyltransferase) (Nat2), mRNA [NM_010874]	KLA	1.160	0.980	1.170	2.420	1.370	1.280	0.770
					Compactin	1.110	1.070	1.090	1.180	1.060	0.990	0.970
					KLA/Compactin	1.050	0.970	1.040	2.440	1.550	1.300	0.630

Nat3	KLA Compactin Compactin+KLA	NM_008674	N-acetyltransferase 3 (Nat3), mRNA [NM_008674]	KLA	0.980	1.000	0.970	0.980	0.980	1.030	1.040
				Compactin	0.890	1.000	1.060	0.990	1.010	0.960	1.000
				KLA/Compactin	0.980	0.970	0.950	0.960	1.000	1.090	1.060

Uox	KLA Compactin Compactin+KLA	NM_009474		urate oxidase (Uox), mRNA [NM_009474]	KLA	0.980	1.020	1.040	1.060	0.970	1.110	1.030
					Compactin	1.030	1.080	1.010	1.000	0.970	1.030	0.980
					KLA/Compactin	1.040	1.050	1.020	1.040	0.970	1.050	0.980

Uox	KLA Compactin Compactin+KLA	NM_009474	urate oxidase (Uox), mRNA [NM_009474]	KLA	1.030	0.990	1.000	1.030	0.980	1.020	1.020
				Compactin	0.950	0.990	0.930	0.970	0.940	1.030	1.010
				KLA/Compactin	0.990	0.940	1.040	1.010	0.990	0.970	1.010

Xdh	KLA Compactin Compactin+KLA	NM_011723		xanthine dehydrogenase (Xdh), mRNA [NM_011723]	KLA	0.880	0.920	0.860	0.830	0.960	0.910	1.840
					Compactin	0.890	0.870	0.880	0.990	0.920	1.060	1.310
					KLA/Compactin	1.000	0.900	0.820	0.830	1.100	1.140	1.970

Xdh	KLA Compactin Compactin+KLA	NM_011723	xanthine dehydrogenase (Xdh), mRNA [NM_011723]	KLA	1.050	0.940	0.930	0.930	1.080	1.120	2.080
				Compactin	1.020	0.890	0.950	1.080	1.050	0.990	1.490
				KLA/Compactin	1.130	0.870	0.860	0.950	1.300	1.230	2.230

Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Caffeine metabolism (mmu00232)

Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

Kdo₂-Lipid A / compactin gene array data - treatment:control ratios