Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Steroid biosynthesis (mmu00100)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
Cel
KLA  Compactin  Compactin+KLA
 NM_009885 carboxyl ester lipase (Cel), mRNA [NM_009885] KLA1.040 1.020 0.890 0.970 1.010 0.950 1.030
Compactin1.030 0.970 0.990 0.890 0.890 1.120 1.010
KLA/Compactin0.830 1.030 1.080 1.050 0.960 1.050 1.190
Cyp24a1
KLA  Compactin  Compactin+KLA
 NM_009996 cytochrome P450, family 24, subfamily a, polypeptide 1 (Cyp24a1), nuclear gene encoding mitochondrial protein, mRNA [NM_009996] KLA0.990 0.960 0.950 0.970 1.020 1.110 1.020
Compactin0.960 1.010 1.070 0.990 0.890 0.940 1.050
KLA/Compactin1.010 0.970 1.020 1.030 0.980 1.050 1.010
Cyp27b1
KLA  Compactin  Compactin+KLA
 AB006034 mRNA for 25-hydroxyvitamin D3 1alpha-hydroxylase, partial cds. [AB006034] KLA0.990 0.980 0.970 0.980 1.000 0.890 1.080
Compactin1.030 1.040 1.000 1.060 0.970 1.000 1.130
KLA/Compactin1.050 1.000 0.950 1.050 0.940 0.970 0.950
Cyp27b1
KLA  Compactin  Compactin+KLA
 AB006034 mRNA for 25-hydroxyvitamin D3 1alpha-hydroxylase, partial cds. [AB006034] KLA1.000 1.030 1.040 0.980 0.930 1.060 1.000
Compactin0.950 0.920 0.940 1.000 0.960 0.990 1.020
KLA/Compactin1.060 0.940 0.990 1.030 0.950 0.900 1.000
Cyp27b1
KLA  Compactin  Compactin+KLA
 NM_010009 cytochrome P450, family 27, subfamily b, polypeptide 1 (Cyp27b1), nuclear gene encoding mitochondrial protein, mRNA [NM_010009] KLA1.050 0.910 1.010 1.090 0.920 1.000 0.910
Compactin0.900 0.880 0.940 0.960 1.000 1.010 0.920
KLA/Compactin0.920 1.010 1.050 0.880 0.880 0.910 0.980
Cyp2r1
KLA  Compactin  Compactin+KLA
 NM_177382 cytochrome P450, family 2, subfamily r, polypeptide 1 (Cyp2r1), mRNA [NM_177382] KLA1.130 1.030 0.990 0.980 0.890 1.020 0.960
Compactin1.090 0.940 1.070 1.050 1.070 1.030 0.990
KLA/Compactin1.030 0.960 0.970 1.010 0.960 1.060 0.980
Cyp51
KLA  Compactin  Compactin+KLA
 NM_020010 cytochrome P450, family 51 (Cyp51), mRNA [NM_020010] KLA0.980 1.190 1.090 0.850 1.080 0.980 0.850
Compactin1.000 1.010 1.110 0.900 1.000 1.270 0.990
KLA/Compactin0.910 1.210 1.490 0.980 0.720 0.920 1.120
Cyp51
KLA  Compactin  Compactin+KLA
 NM_020010 cytochrome P450, family 51 (Cyp51), mRNA [NM_020010] KLA0.990 1.240 1.290 0.590 0.590 0.650 0.600
Compactin1.030 0.940 1.230 1.130 1.040 1.080 0.820
KLA/Compactin1.070 1.070 1.340 0.730 0.670 0.650 0.650
Cyp51
KLA  Compactin  Compactin+KLA
 NM_020010 cytochrome P450, family 51 (Cyp51), mRNA [NM_020010] KLA1.260 1.370 1.520 0.980 1.000 0.900 0.750
Compactin1.220 1.140 1.060 1.350 1.290 1.120 0.940
KLA/Compactin1.370 1.270 1.840 1.120 0.960 0.910 0.900
Dhcr24
KLA  Compactin  Compactin+KLA
 NM_053272 24-dehydrocholesterol reductase (Dhcr24), mRNA [NM_053272] KLA1.060 0.890 0.940 0.520 0.600 0.590 0.330
Compactin0.990 0.990 0.990 0.960 1.080 1.090 0.910
KLA/Compactin1.020 0.910 1.030 0.430 0.540 0.510 0.420
Dhcr24
KLA  Compactin  Compactin+KLA
 NM_053272 24-dehydrocholesterol reductase (Dhcr24), mRNA [NM_053272] KLA1.120 0.970 0.900 0.480 0.450 0.380 0.150
Compactin1.010 1.090 1.040 1.000 1.030 1.220 0.930
KLA/Compactin1.050 1.000 1.040 0.570 0.450 0.310 0.170
Dhcr7
KLA  Compactin  Compactin+KLA
 NM_007856 7-dehydrocholesterol reductase (Dhcr7), mRNA [NM_007856] KLA1.000 1.010 0.860 0.540 0.760 1.050 1.210
Compactin1.200 1.150 1.140 1.400 1.170 1.080 0.950
KLA/Compactin1.220 1.060 0.860 0.580 0.810 1.050 1.260
Dhcr7
KLA  Compactin  Compactin+KLA
 NM_007856 7-dehydrocholesterol reductase (Dhcr7), mRNA [NM_007856] KLA1.220 1.140 0.800 0.330 0.570 0.940 1.100
Compactin1.290 1.160 1.190 1.500 1.220 0.880 1.050
KLA/Compactin1.300 0.980 0.810 0.400 0.600 0.960 1.160
Ebp
KLA  Compactin  Compactin+KLA
 NM_007898 phenylalkylamine Ca2+ antagonist (emopamil) binding protein (Ebp), mRNA [NM_007898] KLA1.180 1.170 1.040 0.950 0.710 0.820 0.910
Compactin1.240 1.160 1.120 1.160 1.150 1.030 1.060
KLA/Compactin1.140 0.900 1.040 1.080 0.760 0.730 1.180
Hsd17b7
KLA  Compactin  Compactin+KLA
 NM_010476 hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7), mRNA [NM_010476] KLA1.140 1.190 1.220 0.880 1.380 1.170 0.840
Compactin0.950 1.050 1.000 0.980 1.080 1.070 1.270
KLA/Compactin1.150 1.240 1.510 0.880 1.170 1.150 1.080
Hsd17b7
KLA  Compactin  Compactin+KLA
 NM_010476 hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7), mRNA [NM_010476] KLA1.300 1.420 1.450 1.220 1.170 1.370 0.860
Compactin1.220 1.130 1.090 1.250 1.180 1.090 1.030
KLA/Compactin1.160 1.310 1.750 1.490 1.320 1.080 0.910
Lipa
KLA  Compactin  Compactin+KLA
 AK083099 adult male hippocampus cDNA, RIKEN full-length enriched library, clone:C630012O05 product:unclassifiable, full insert sequence. [AK083099] KLA0.660 0.680 0.820 0.860 0.950 1.040 0.840
Compactin1.100 1.030 1.100 0.990 1.010 0.940 0.940
KLA/Compactin0.790 0.600 0.800 0.920 0.960 0.910 0.860
Lipa
KLA  Compactin  Compactin+KLA
 NM_021460 lysosomal acid lipase A (Lipa), transcript variant 1, mRNA [NM_021460] KLA0.980 0.980 0.830 0.730 0.800 0.890 0.690
Compactin1.020 0.990 1.100 1.150 0.940 0.940 0.700
KLA/Compactin1.050 0.890 0.890 0.740 0.690 0.750 0.600
Lss
KLA  Compactin  Compactin+KLA
 AK147680 adult male brain UNDEFINED_CELL_LINE cDNA, RIKEN full-length enriched library, clone:M5C1106O04 product:lanosterol synthase, full insert sequence [AK147680] KLA1.110 0.910 0.720 0.560 0.680 0.730 0.550
Compactin1.130 1.080 1.220 1.230 1.180 0.900 0.760
KLA/Compactin1.150 0.910 0.800 0.750 0.670 0.530 0.480
Lss
KLA  Compactin  Compactin+KLA
 NM_146006 lanosterol synthase (Lss), mRNA [NM_146006] KLA1.000 0.900 0.950 0.710 1.090 1.240 1.040
Compactin0.990 0.980 0.980 0.970 1.140 1.080 0.950
KLA/Compactin0.980 0.920 1.070 0.870 0.950 1.020 1.140
Lss
KLA  Compactin  Compactin+KLA
 NM_146006 lanosterol synthase (Lss), mRNA [NM_146006] KLA1.060 1.070 1.050 0.830 0.960 1.190 1.140
Compactin1.010 1.020 0.940 1.130 1.190 1.120 0.980
KLA/Compactin1.030 0.940 1.150 0.910 1.000 1.090 1.130
Nsdhl
KLA  Compactin  Compactin+KLA
 AK156993 activated spleen cDNA, RIKEN full-length enriched library, clone:F830111P16 product:unclassifiable, full insert sequence [AK156993] KLA1.000 0.960 0.870 0.800 0.900 0.990 0.920
Compactin0.990 1.010 1.060 0.970 1.080 0.910 1.080
KLA/Compactin1.090 0.920 0.960 0.850 0.890 0.860 0.910
Nsdhl
KLA  Compactin  Compactin+KLA
 AK156993 activated spleen cDNA, RIKEN full-length enriched library, clone:F830111P16 product:unclassifiable, full insert sequence [AK156993] KLA1.080 0.940 0.860 0.790 0.880 0.920 0.900
Compactin1.060 1.010 1.020 0.980 1.070 0.980 0.990
KLA/Compactin1.060 0.940 0.890 0.830 0.830 0.890 0.980
Nsdhl
KLA  Compactin  Compactin+KLA
 NM_010941 NAD(P) dependent steroid dehydrogenase-like (Nsdhl), mRNA [NM_010941] KLA1.070 1.020 1.040 0.900 0.760 0.930 0.870
Compactin0.920 0.980 1.060 1.080 1.070 1.040 0.750
KLA/Compactin0.980 0.900 1.060 0.910 1.220 1.050 1.040
Nsdhl
KLA  Compactin  Compactin+KLA
 NM_010941 NAD(P) dependent steroid dehydrogenase-like (Nsdhl), mRNA [NM_010941] KLA1.100 1.040 1.190 0.950 0.970 0.930 0.860
Compactin1.240 1.090 1.080 1.280 1.210 1.110 0.750
KLA/Compactin1.180 0.970 1.210 1.110 1.180 0.890 0.910
Nsdhl
KLA  Compactin  Compactin+KLA
 NM_010941 NAD(P) dependent steroid dehydrogenase-like (Nsdhl), mRNA [NM_010941] KLA1.370 1.100 1.250 1.000 0.940 1.000 0.970
Compactin1.220 1.200 1.090 1.340 1.190 1.040 0.830
KLA/Compactin1.210 1.100 1.100 1.070 1.180 0.920 0.950
Sc4mol
KLA  Compactin  Compactin+KLA
 NM_025436 sterol-C4-methyl oxidase-like (Sc4mol), mRNA [NM_025436] KLA0.950 1.130 1.080 0.600 0.900 1.070 0.940
Compactin0.890 0.920 0.900 0.920 0.890 1.070 1.280
KLA/Compactin0.980 0.950 1.100 0.780 1.000 1.180 1.300
Sc5d
KLA  Compactin  Compactin+KLA
 AK080673 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830073K23 product:unclassifiable, full insert sequence [AK080673] KLA1.210 1.090 0.670 0.620 0.580 0.640 0.620
Compactin1.030 1.000 1.230 1.150 1.030 0.890 0.920
KLA/Compactin1.230 1.020 0.830 0.680 0.550 0.590 0.600
Sc5d
KLA  Compactin  Compactin+KLA
 NM_172769 sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) (Sc5d), mRNA [NM_172769] KLA0.990 1.120 1.060 0.920 1.050 1.180 1.600
Compactin0.910 0.980 0.910 1.050 0.900 0.970 1.130
KLA/Compactin0.880 1.170 1.240 0.990 0.920 1.150 1.560
Sc5d
KLA  Compactin  Compactin+KLA
 NM_172769 sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) (Sc5d), mRNA [NM_172769] KLA1.090 1.280 1.270 1.020 0.950 1.140 1.650
Compactin1.030 1.130 1.140 1.210 0.940 1.010 1.060
KLA/Compactin1.060 1.120 1.360 1.250 1.040 1.160 1.600
Soat1
KLA  Compactin  Compactin+KLA
 NM_009230 sterol O-acyltransferase 1 (Soat1), mRNA [NM_009230] KLA1.060 1.020 0.740 1.050 1.180 1.110 1.230
Compactin0.980 1.050 1.080 0.770 0.890 0.940 0.690
KLA/Compactin1.020 1.020 0.930 0.930 0.790 0.970 1.550
Soat1
KLA  Compactin  Compactin+KLA
 NM_009230 sterol O-acyltransferase 1 (Soat1), mRNA [NM_009230] KLA1.080 1.100 1.080 0.980 0.890 0.790 0.600
Compactin1.200 1.020 1.130 1.080 0.890 0.790 0.610
KLA/Compactin1.230 0.890 0.930 0.870 0.630 0.560 0.480
Soat1
KLA  Compactin  Compactin+KLA
 NM_009230 sterol O-acyltransferase 1 (Soat1), mRNA [NM_009230] KLA1.230 1.060 1.180 1.060 1.300 1.320 1.790
Compactin1.200 1.100 1.060 1.110 0.910 0.820 0.770
KLA/Compactin1.140 1.110 1.190 1.140 1.140 1.070 1.530
Soat2
KLA  Compactin  Compactin+KLA
 NM_146064 sterol O-acyltransferase 2 (Soat2), mRNA [NM_146064] KLA0.920 1.000 1.000 0.990 1.470 2.000 1.590
Compactin0.860 0.980 0.970 1.030 1.080 0.860 1.750
KLA/Compactin0.990 0.890 1.030 1.080 1.660 2.180 1.560
Tm7sf2
KLA  Compactin  Compactin+KLA
 NM_028454 transmembrane 7 superfamily member 2 (Tm7sf2), mRNA [NM_028454] KLA1.050 0.930 0.940 0.780 0.640 0.640 1.030
Compactin1.070 1.070 1.120 1.220 1.100 1.290 1.250
KLA/Compactin1.100 0.870 1.000 0.920 0.840 0.690 1.180