Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Citrate cycle (TCA cycle) (mmu00020)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
1500032O
14Rik
KLA  Compactin  Compactin+KLA
 AK005350 adult male cerebellum cDNA, RIKEN full-length enriched library, clone:1500032O14 product:succinate dehydrogenase complex, subunit A, flavoprotein (Fp), full insert sequence. [AK005350] KLA0.740 0.870 0.940 0.750 0.920 0.890 0.780
Compactin0.930 1.050 1.050 0.850 1.070 0.990 0.920
KLA/Compactin0.820 0.860 0.900 0.710 0.850 0.870 0.760
4933405O
20Rik
KLA  Compactin  Compactin+KLA
 NM_172901 RIKEN cDNA 4933405O20 gene (4933405O20Rik), mRNA [NM_172901] KLA1.000 1.000 0.990 0.940 0.970 0.930 0.970
Compactin1.090 0.950 0.980 1.000 1.030 1.010 1.010
KLA/Compactin0.980 1.040 1.040 1.000 0.990 1.010 1.010
AK031343
KLA  Compactin  Compactin+KLA
 AK031343 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030410A06 product:unclassifiable, full insert sequence [AK031343] KLA0.970 0.990 1.080 1.020 1.000 1.000 1.000
Compactin0.990 1.010 0.990 0.980 1.010 1.010 0.960
KLA/Compactin0.960 0.930 1.030 0.990 0.960 1.010 0.980
Acly
KLA  Compactin  Compactin+KLA
 AK043466 7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730098H14 product:unclassifiable, full insert sequence. [AK043466] KLA1.010 0.980 0.940 0.930 1.080 1.030 1.000
Compactin1.040 1.080 0.980 0.960 0.980 1.000 0.970
KLA/Compactin0.990 1.030 0.930 0.990 1.000 1.050 1.050
Acly
KLA  Compactin  Compactin+KLA
 NM_134037 ATP citrate lyase (Acly), mRNA [NM_134037] KLA1.200 1.070 1.310 1.050 1.250 1.230 1.390
Compactin1.280 1.200 1.130 1.370 1.260 1.140 0.970
KLA/Compactin1.280 1.130 1.260 1.100 1.380 1.250 1.260
Aco1
KLA  Compactin  Compactin+KLA
 NM_007386 aconitase 1 (Aco1), mRNA [NM_007386] KLA1.020 0.960 1.010 1.000 0.920 0.940 0.970
Compactin1.070 1.100 1.040 1.020 1.040 0.960 0.930
KLA/Compactin1.060 1.040 0.980 0.970 0.890 0.870 0.900
Aco1
KLA  Compactin  Compactin+KLA
 NM_007386 aconitase 1 (Aco1), mRNA [NM_007386] KLA1.140 1.090 0.940 0.850 0.880 1.040 0.960
Compactin1.270 1.190 1.140 1.140 1.260 1.060 1.020
KLA/Compactin1.130 1.100 1.060 0.910 1.060 0.980 0.940
Aco2
KLA  Compactin  Compactin+KLA
 AK029122 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732494K09 product:hypothetical protein, full insert sequence [AK029122] KLA0.940 1.040 1.020 0.970 1.010 1.040 0.980
Compactin0.990 0.990 1.000 1.020 0.980 0.990 0.910
KLA/Compactin0.940 1.030 0.960 0.970 0.960 0.960 1.060
Aco2
KLA  Compactin  Compactin+KLA
 NM_080633 aconitase 2, mitochondrial (Aco2), nuclear gene encoding mitochondrial protein, mRNA [NM_080633] KLA1.610 1.480 1.170 1.030 0.860 0.980 1.110
Compactin1.000 1.330 1.540 1.170 1.090 0.880 0.930
KLA/Compactin1.370 1.130 1.320 1.180 0.970 0.960 0.750
Cs
KLA  Compactin  Compactin+KLA
 NM_026444 citrate synthase (Cs), nuclear gene encoding mitochondrial protein, mRNA [NM_026444] KLA1.010 0.960 1.060 0.940 0.790 0.970 0.950
Compactin1.060 0.950 1.120 1.190 1.000 1.090 1.080
KLA/Compactin1.160 1.020 1.020 1.010 0.920 0.860 0.720
Cs
KLA  Compactin  Compactin+KLA
 NM_026444 citrate synthase (Cs), nuclear gene encoding mitochondrial protein, mRNA [NM_026444] KLA1.170 1.140 1.160 1.090 1.070 1.280 1.460
Compactin1.180 1.140 1.120 1.250 1.080 1.020 1.120
KLA/Compactin1.230 1.070 1.140 1.260 1.130 1.090 1.660
Csl
KLA  Compactin  Compactin+KLA
 NM_027945 citrate synthase like (Csl), mRNA [NM_027945] KLA0.880 0.970 0.880 1.070 1.080 0.940 1.590
Compactin0.960 0.880 0.780 0.790 1.120 1.050 0.880
KLA/Compactin0.970 1.020 0.920 0.910 0.960 1.440 1.770
Dlat
KLA  Compactin  Compactin+KLA
 NM_145614 dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat), mRNA [NM_145614] KLA0.990 1.070 1.020 0.920 0.910 0.590 0.420
Compactin1.120 0.980 1.020 1.040 0.940 0.880 0.930
KLA/Compactin1.070 1.030 1.030 0.970 0.810 0.610 0.360
Dlat
KLA  Compactin  Compactin+KLA
 NM_145614 dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat), mRNA [NM_145614] KLA1.080 0.900 1.090 1.110 0.860 0.910 1.480
Compactin1.240 1.050 1.050 1.040 1.080 0.950 1.060
KLA/Compactin1.210 1.080 1.020 1.100 0.970 1.090 1.280
Dld
KLA  Compactin  Compactin+KLA
 NM_007861 dihydrolipoamide dehydrogenase (Dld), mRNA [NM_007861] KLA0.850 0.700 0.970 1.100 1.070 1.150 1.180
Compactin0.880 0.790 0.950 0.720 0.840 0.810 0.830
KLA/Compactin0.790 1.020 0.990 1.080 1.340 1.490 1.180
Dld
KLA  Compactin  Compactin+KLA
 NM_007861 dihydrolipoamide dehydrogenase (Dld), mRNA [NM_007861] KLA0.850 0.860 0.980 1.120 1.210 1.460 1.280
Compactin0.780 0.910 0.830 0.940 0.850 0.830 1.120
KLA/Compactin0.780 0.920 0.960 0.900 1.480 1.430 1.050
Dld
KLA  Compactin  Compactin+KLA
 U73445 dihydrolipoamide dehydrogenase (Dld) mRNA, complete cds. [U73445] KLA1.070 1.150 1.230 1.240 1.420 1.690 1.380
Compactin0.900 1.090 1.080 0.980 1.020 0.920 1.130
KLA/Compactin1.040 1.030 1.170 1.290 2.010 1.940 1.210
Dlst
KLA  Compactin  Compactin+KLA
 AK171100 NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630223O05 product:dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), full insert sequence [AK171100] KLA1.180 1.000 0.960 0.930 0.980 1.190 0.890
Compactin0.920 0.930 0.970 0.910 1.170 1.050 1.040
KLA/Compactin1.080 1.090 0.930 0.990 1.150 0.960 0.940
Dlst
KLA  Compactin  Compactin+KLA
 NM_030225 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (Dlst), mRNA [NM_030225] KLA1.280 1.080 1.310 1.240 1.260 1.220 2.260
Compactin1.240 1.180 1.070 1.220 1.200 1.180 0.980
KLA/Compactin1.290 1.060 1.200 1.220 1.450 1.330 2.560
Dlst
KLA  Compactin  Compactin+KLA
 NM_030225 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (Dlst), mRNA [NM_030225] KLA1.580 1.220 1.420 1.180 1.170 1.400 2.900
Compactin1.300 1.190 1.080 1.320 1.180 1.240 1.090
KLA/Compactin1.290 1.190 1.160 1.180 1.390 1.440 2.580
Fh1
KLA  Compactin  Compactin+KLA
 NM_010209 fumarate hydratase 1 (Fh1), mRNA [NM_010209] KLA0.920 0.950 0.760 0.660 1.210 0.570 0.460
Compactin0.880 1.000 0.650 0.690 0.730 0.880 0.900
KLA/Compactin0.700 0.790 0.980 0.790 0.420 0.440 0.670
Idh1
KLA  Compactin  Compactin+KLA
 NM_010497 isocitrate dehydrogenase 1 (NADP+), soluble (Idh1), transcript variant 2, mRNA [NM_010497] KLA0.990 0.560 0.780 0.700 0.500 0.530 0.470
Compactin0.920 0.990 0.790 0.800 1.010 1.280 0.980
KLA/Compactin0.840 0.830 0.710 0.590 0.530 0.600 0.450
Idh2
KLA  Compactin  Compactin+KLA
 NM_173011 isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2), nuclear gene encoding mitochondrial protein, mRNA [NM_173011] KLA0.870 0.920 0.850 0.810 0.680 0.530 0.570
Compactin0.980 0.910 0.840 0.830 1.060 0.950 0.690
KLA/Compactin0.950 1.000 0.800 0.710 0.660 0.470 0.660
Idh3a
KLA  Compactin  Compactin+KLA
 NM_029573 isocitrate dehydrogenase 3 (NAD+) alpha (Idh3a), nuclear gene encoding mitochondrial protein, mRNA [NM_029573] KLA1.220 1.180 1.190 0.950 0.720 0.660 0.820
Compactin1.170 1.090 1.100 1.140 1.150 0.980 0.870
KLA/Compactin1.180 1.030 1.050 1.050 0.760 0.640 0.700
Idh3b
KLA  Compactin  Compactin+KLA
 NM_130884 isocitrate dehydrogenase 3 (NAD+) beta (Idh3b), nuclear gene encoding mitochondrial protein, mRNA [NM_130884] KLA1.030 1.070 1.120 0.960 0.980 1.010 1.130
Compactin1.000 1.000 1.160 1.060 0.990 1.120 0.960
KLA/Compactin1.180 0.980 1.200 1.060 0.970 0.900 1.180
Idh3b
KLA  Compactin  Compactin+KLA
 NM_130884 isocitrate dehydrogenase 3 (NAD+) beta (Idh3b), nuclear gene encoding mitochondrial protein, mRNA [NM_130884] KLA1.210 1.160 1.200 1.080 1.150 1.060 0.930
Compactin1.060 1.080 1.190 1.000 1.130 0.890 0.800
KLA/Compactin1.130 0.940 1.260 1.130 1.070 0.970 1.140
Idh3g
KLA  Compactin  Compactin+KLA
 NM_008323 isocitrate dehydrogenase 3 (NAD+), gamma (Idh3g), nuclear gene encoding mitochondrial protein, mRNA [NM_008323] KLA1.160 1.050 1.080 0.970 0.890 0.640 0.480
Compactin0.930 1.230 1.370 1.000 1.050 0.920 0.840
KLA/Compactin0.900 0.920 1.370 0.980 0.810 0.570 0.560
Mdh1
KLA  Compactin  Compactin+KLA
 AK077724 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730556L21 product:unclassifiable, full insert sequence [AK077724] KLA0.770 0.750 0.810 0.650 0.850 0.880 0.910
Compactin1.040 1.050 1.010 0.960 1.050 0.860 1.060
KLA/Compactin0.760 0.710 0.790 0.700 0.820 0.800 0.880
Mdh1
KLA  Compactin  Compactin+KLA
 NM_008618 malate dehydrogenase 1, NAD (soluble) (Mdh1), mRNA [NM_008618] KLA1.020 0.980 1.020 0.860 0.570 0.600 0.650
Compactin1.070 1.030 1.160 1.140 1.100 1.040 0.860
KLA/Compactin1.090 0.970 0.930 0.950 0.620 0.580 0.590
Mdh1
KLA  Compactin  Compactin+KLA
 NM_008618 malate dehydrogenase 1, NAD (soluble) (Mdh1), mRNA [NM_008618] KLA1.050 1.000 0.780 0.770 0.870 0.550 0.560
Compactin0.960 1.040 1.100 0.890 1.170 1.150 1.060
KLA/Compactin0.810 0.900 0.920 0.790 0.570 0.490 0.710
Mdh2
KLA  Compactin  Compactin+KLA
 NM_008617 malate dehydrogenase 2, NAD (mitochondrial) (Mdh2), nuclear gene encoding mitochondrial protein, mRNA [NM_008617] KLA0.970 0.790 0.930 0.880 0.950 0.940 0.940
Compactin0.930 0.910 0.970 0.960 1.010 0.930 0.910
KLA/Compactin0.980 0.810 0.980 0.800 0.870 0.890 0.910
Ogdh
KLA  Compactin  Compactin+KLA
 NM_010956 oxoglutarate dehydrogenase (lipoamide) (Ogdh), nuclear gene encoding mitochondrial protein, mRNA [NM_010956] KLA1.000 0.930 1.020 0.950 0.930 0.870 1.300
Compactin1.000 0.900 0.970 0.960 0.860 0.990 0.930
KLA/Compactin0.890 0.990 0.960 0.870 0.870 0.970 1.200
Ogdh
KLA  Compactin  Compactin+KLA
 NM_010956 oxoglutarate dehydrogenase (lipoamide) (Ogdh), nuclear gene encoding mitochondrial protein, mRNA [NM_010956] KLA1.020 1.120 1.050 1.000 1.030 0.980 1.170
Compactin1.190 1.090 1.070 1.180 1.080 0.990 0.960
KLA/Compactin1.120 1.040 1.160 1.130 1.050 0.870 1.170
Ogdhl
KLA  Compactin  Compactin+KLA
 124487482 oxoglutarate dehydrogenase-like KLA1.140 0.980 1.010 1.040 0.940 1.040 1.280
Compactin1.010 0.930 1.000 0.980 1.000 1.030 0.980
KLA/Compactin0.950 0.980 1.050 0.980 0.970 1.150 1.000
Ogdhl
KLA  Compactin  Compactin+KLA
 NM_001081130 oxoglutarate dehydrogenase-like (Ogdhl), mRNA [NM_001081130] KLA1.000 0.990 1.030 1.030 0.930 0.910 0.930
Compactin0.950 1.020 1.000 0.960 0.970 1.020 0.980
KLA/Compactin1.010 0.960 1.020 0.990 0.970 1.000 0.930
Pck2
KLA  Compactin  Compactin+KLA
 NM_028994 phosphoenolpyruvate carboxykinase 2 (mitochondrial) (Pck2), nuclear gene encoding mitochondrial protein, mRNA [NM_028994] KLA1.000 0.860 0.820 0.670 1.380 1.490 0.930
Compactin0.880 1.110 1.140 1.080 1.200 1.130 1.170
KLA/Compactin0.880 0.980 0.820 1.030 1.380 1.550 1.200
Pcx
KLA  Compactin  Compactin+KLA
 142351600 pyruvate carboxylase KLA1.040 1.040 1.090 0.910 0.590 0.530 0.640
Compactin1.080 1.080 1.090 1.100 0.960 0.940 0.640
KLA/Compactin1.130 1.120 1.050 1.010 0.590 0.550 0.560
Pcx
KLA  Compactin  Compactin+KLA
 NM_008797 pyruvate carboxylase (Pcx), nuclear gene encoding mitochondrial protein, mRNA [NM_008797] KLA0.760 1.010 0.790 1.000 0.960 0.750 0.900
Compactin0.840 0.940 0.990 0.970 0.960 0.990 0.860
KLA/Compactin1.030 0.950 1.020 0.930 0.780 0.720 1.050
Pdha1
KLA  Compactin  Compactin+KLA
 NM_008810 pyruvate dehydrogenase E1 alpha 1 (Pdha1), nuclear gene encoding mitochondrial protein, mRNA [NM_008810] KLA1.050 1.080 1.140 1.190 1.260 1.730 2.270
Compactin1.060 1.190 1.100 1.270 1.020 1.150 1.190
KLA/Compactin1.140 1.190 1.130 1.300 1.320 1.690 2.510
Pdha1
KLA  Compactin  Compactin+KLA
 NM_008810 pyruvate dehydrogenase E1 alpha 1 (Pdha1), nuclear gene encoding mitochondrial protein, mRNA [NM_008810] KLA1.200 1.140 1.090 1.160 1.010 0.940 0.870
Compactin1.060 1.120 1.040 1.280 1.120 0.900 1.070
KLA/Compactin1.150 1.080 1.100 1.160 1.060 1.050 0.760
Pdha2
KLA  Compactin  Compactin+KLA
 NM_008811 pyruvate dehydrogenase E1 alpha 2 (Pdha2), mRNA [NM_008811] KLA0.970 1.040 0.940 0.970 1.020 1.100 1.020
Compactin0.900 1.030 1.000 0.990 0.940 1.030 1.050
KLA/Compactin0.980 0.940 0.980 1.110 0.950 0.970 1.020
Pdhb
KLA  Compactin  Compactin+KLA
 NM_024221 pyruvate dehydrogenase (lipoamide) beta (Pdhb), mRNA [NM_024221] KLA0.930 0.850 0.870 0.950 0.860 0.870 1.010
Compactin0.870 0.930 0.820 1.050 0.940 0.860 0.940
KLA/Compactin0.820 0.970 0.900 0.780 0.900 0.850 0.740
Pdhb
KLA  Compactin  Compactin+KLA
 NM_024221 pyruvate dehydrogenase (lipoamide) beta (Pdhb), mRNA [NM_024221] KLA0.940 0.920 0.880 0.920 0.990 0.900 0.870
Compactin0.760 0.760 0.930 0.790 0.890 0.870 0.860
KLA/Compactin0.820 0.840 0.860 1.060 0.810 0.810 0.790
Pdhx
KLA  Compactin  Compactin+KLA
 NM_175094 pyruvate dehydrogenase complex, component X (Pdhx), nuclear gene encoding mitochondrial protein, mRNA [NM_175094] KLA0.880 0.940 0.890 0.940 0.730 0.690 0.650
Compactin0.930 0.940 0.900 0.840 1.010 1.000 0.880
KLA/Compactin0.940 1.060 1.010 0.840 0.670 0.690 0.640
Pdhx
KLA  Compactin  Compactin+KLA
 NM_175094 pyruvate dehydrogenase complex, component X (Pdhx), nuclear gene encoding mitochondrial protein, mRNA [NM_175094] KLA0.950 1.020 1.030 0.910 0.830 1.120 1.500
Compactin0.900 0.950 0.870 1.040 0.870 0.930 0.950
KLA/Compactin0.930 0.940 0.940 0.940 0.850 1.140 1.280
Sdha
KLA  Compactin  Compactin+KLA
 NM_023281 succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (Sdha), nuclear gene encoding mitochondrial protein, mRNA [NM_023281] KLA1.020 0.790 0.860 0.870 0.630 0.670 0.790
Compactin1.040 0.930 1.080 1.000 1.050 0.950 0.670
KLA/Compactin0.920 1.020 0.930 0.830 0.830 0.640 0.670
Sdha
KLA  Compactin  Compactin+KLA
 NM_023281 succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (Sdha), nuclear gene encoding mitochondrial protein, mRNA [NM_023281] KLA1.090 1.010 1.070 0.950 0.700 0.650 0.810
Compactin1.080 1.110 1.090 1.170 1.080 0.980 0.760
KLA/Compactin1.210 0.990 0.940 0.950 0.810 0.800 0.830
Sdhb
KLA  Compactin  Compactin+KLA
 NM_023374 succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb), mRNA [NM_023374] KLA0.970 0.810 0.810 1.020 0.680 0.640 0.970
Compactin1.070 0.900 1.130 0.810 1.070 0.950 0.710
KLA/Compactin0.860 0.980 0.760 0.820 0.860 0.880 1.210
Sdhc
KLA  Compactin  Compactin+KLA
 NM_025321 succinate dehydrogenase complex, subunit C, integral membrane protein (Sdhc), nuclear gene encoding mitochondrial protein, mRNA [NM_025321] KLA0.910 0.870 0.930 1.000 0.750 0.940 1.220
Compactin0.900 0.890 0.880 1.060 0.980 0.970 0.860
KLA/Compactin0.840 0.860 0.890 0.880 1.120 0.950 1.030
Sdhd
KLA  Compactin  Compactin+KLA
 NM_025848 succinate dehydrogenase complex, subunit D, integral membrane protein (Sdhd), nuclear gene encoding mitochondrial protein, mRNA [NM_025848] KLA0.940 0.890 0.850 0.950 0.610 0.540 0.910
Compactin1.180 1.040 0.980 1.220 1.100 0.790 0.660
KLA/Compactin0.950 0.940 0.930 0.950 0.700 0.650 0.730
Sucla2
KLA  Compactin  Compactin+KLA
 AK016060 adult male testis cDNA, RIKEN full-length enriched library, clone:4930547K18 product:unclassifiable, full insert sequence. [AK016060] KLA1.000 1.050 1.060 1.060 0.990 1.030 1.000
Compactin1.040 1.020 1.060 0.980 1.030 1.020 1.030
KLA/Compactin1.000 0.990 1.030 1.020 1.020 1.010 1.050
Sucla2
KLA  Compactin  Compactin+KLA
 NM_011506 succinate-Coenzyme A ligase, ADP-forming, beta subunit (Sucla2), nuclear gene encoding mitochondrial protein, mRNA [NM_011506] KLA0.800 0.870 0.760 0.970 0.840 0.660 0.430
Compactin0.810 1.000 1.060 0.780 1.000 1.000 0.840
KLA/Compactin0.970 0.910 0.960 0.850 0.760 0.660 0.460
Sucla2
KLA  Compactin  Compactin+KLA
 NM_011506 succinate-Coenzyme A ligase, ADP-forming, beta subunit (Sucla2), nuclear gene encoding mitochondrial protein, mRNA [NM_011506] KLA1.070 1.070 1.110 1.050 1.100 1.050 1.220
Compactin1.020 1.200 1.160 1.230 1.050 1.140 0.960
KLA/Compactin1.050 1.050 1.050 1.030 1.090 1.140 1.270
Suclg1
KLA  Compactin  Compactin+KLA
 NM_019879 succinate-CoA ligase, GDP-forming, alpha subunit (Suclg1), mRNA [NM_019879] KLA0.790 0.890 0.700 0.810 1.060 0.810 0.890
Compactin0.820 0.940 0.960 0.790 1.060 1.210 0.880
KLA/Compactin0.860 0.910 0.890 0.890 0.770 0.750 1.080
Suclg2
KLA  Compactin  Compactin+KLA
 NM_011507 succinate-Coenzyme A ligase, GDP-forming, beta subunit (Suclg2), mRNA [NM_011507] KLA0.930 0.960 1.120 0.880 0.770 0.720 0.710
Compactin0.960 0.930 0.960 1.050 1.050 0.960 0.690
KLA/Compactin0.990 1.070 1.180 0.830 0.800 0.720 0.620
Suclg2
KLA  Compactin  Compactin+KLA
 NM_011507 succinate-Coenzyme A ligase, GDP-forming, beta subunit (Suclg2), mRNA [NM_011507] KLA1.110 1.100 1.140 1.180 0.860 0.780 0.730
Compactin1.140 1.080 1.170 1.280 1.120 0.980 0.800
KLA/Compactin1.080 1.130 1.160 1.150 0.860 0.630 0.590