Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Thyroid cancer (mmu05216)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
Braf	KLA  ATP  ATP+KLA	NM_139294	Braf transforming gene (Braf), mRNA [NM_139294]	KLA	1.52	1.57	1.55	1.33	1.83	1.52	1.60
				ATP	1.08	1.17	1.02	1.37	.95	1.15	.95
				KLA/ATP	1.64	1.69	1.39	1.51	1.04	1.31	1.26
Ccdc6	KLA  ATP  ATP+KLA	NM_001111121	coiled-coil domain containing 6 (Ccdc6), mRNA [NM_001111121]	KLA	1.76	1.92	2.07	1.95	1.37	1.16	1.01
				ATP	1.08	1.04	.78	.74	.59	.70	.85
				KLA/ATP	2.03	1.87	1.38	1.33	.95	.82	.95
Ccnd1	KLA  ATP  ATP+KLA	S78355	gb|Cyl-1=cyclin D1 [mice, BALB/c, brain, mRNA, 3737 nt]. [S78355]	KLA	.24	.23	.23	.24	.29	.47	.17
				ATP	1.02	1.02	.88	.80	.52	.10	.21
				KLA/ATP	.27	.23	.22	.24	.27	.25	.14
Cdh1	KLA  ATP  ATP+KLA	NM_009864	cadherin 1 (Cdh1), mRNA [NM_009864]	KLA	1.03	1.03	.99	.94	.95	.97	.99
				ATP	1.04	1.06	1.06	.96	.99	1.07	.95
				KLA/ATP	1.02	1.07	1.00	.90	.93	.94	.98
Ctnnb1	KLA  ATP  ATP+KLA	AK020013	adult male thymus cDNA, RIKEN full-length enriched library, clone:5830416C23 product:catenin beta, full insert sequence. [AK020013]	KLA	1.06	1.15	1.00	1.06	1.27	1.14	1.03
				ATP	.85	.57	1.74	3.36	4.13	2.19	1.55
				KLA/ATP	1.12	.87	2.47	3.61	3.79	2.21	2.06
Ctnnb1	KLA  ATP  ATP+KLA	NM_007614	catenin (cadherin associated protein), beta 1 (Ctnnb1), mRNA [NM_007614]	KLA	1.02	1.07	1.13	1.03	1.04	.93	.96
				ATP	1.12	1.14	.75	.77	.73	.72	1.52
				KLA/ATP	1.18	1.17	.77	.85	.60	.59	1.35
Hras1	KLA  ATP  ATP+KLA	NM_008284	Harvey rat sarcoma virus oncogene 1 (Hras1), mRNA [NM_008284]	KLA	.79	.82	.77	.82	.94	1.03	1.07
				ATP	1.01	.95	.69	.83	.79	1.12	1.15
				KLA/ATP	.84	.77	.61	.65	.82	1.00	1.05
Kras	KLA  ATP  ATP+KLA	NM_021284	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (Kras), mRNA [NM_021284]	KLA	.53	.49	.40	.42	.49	.95	1.05
				ATP	.98	1.01	1.16	1.17	1.39	1.29	1.74
				KLA/ATP	.50	.47	.50	.56	1.00	1.24	1.58
Lef1	KLA  ATP  ATP+KLA	NM_010703	lymphoid enhancer binding factor 1 (Lef1), mRNA [NM_010703]	KLA	1.00	1.05	1.00	1.05	1.01	1.07	1.07
				ATP	.96	.98	1.03	1.09	.99	1.04	1.00
				KLA/ATP	1.02	.98	.95	1.08	1.02	1.16	1.08
Map2k1	KLA  ATP  ATP+KLA	NM_008927	mitogen-activated protein kinase kinase 1 (Map2k1), mRNA [NM_008927]	KLA	1.82	2.00	2.31	2.03	2.51	2.20	1.51
				ATP	.99	1.14	.81	.87	.90	1.57	1.11
				KLA/ATP	1.90	2.03	1.50	1.93	1.63	2.03	2.06
Map2k2	KLA  ATP  ATP+KLA	NM_023138	mitogen-activated protein kinase kinase 2 (Map2k2), mRNA [NM_023138]	KLA	.96	1.01	1.09	.99	1.11	1.15	1.42
				ATP	1.07	1.05	.74	.86	1.04	1.16	1.21
				KLA/ATP	1.14	1.03	.68	.78	.85	1.01	1.20
Mapk1	KLA  ATP  ATP+KLA	NM_001038663	mitogen-activated protein kinase 1 (Mapk1), transcript variant 2, mRNA [NM_001038663]	KLA	.97	1.03	.93	.86	.79	1.01	1.04
				ATP	.96	1.18	1.01	1.13	.84	1.04	1.16
				KLA/ATP	.99	.99	.84	.87	.63	.96	1.26
Mapk1	KLA  ATP  ATP+KLA	NM_011949	mitogen-activated protein kinase 1 (Mapk1), transcript variant 1, mRNA [NM_011949]	KLA	.88	.80	.80	.73	.75	.76	.65
				ATP	.97	.96	1.06	.88	.90	.68	.48
				KLA/ATP	.82	.81	.78	.65	.64	.64	.45
Mapk3	KLA  ATP  ATP+KLA	NM_011952	mitogen-activated protein kinase 3 (Mapk3), mRNA [NM_011952]	KLA	.81	.85	.88	.72	.79	.73	.90
				ATP	1.13	1.30	.92	1.48	1.08	.68	1.03
				KLA/ATP	1.01	1.01	.66	1.13	.77	.77	1.16
Mm.27304 9	KLA  ATP  ATP+KLA	119672895	Unknown	KLA	.23	.22	.22	.22	.30	.51	.16
				ATP	1.08	1.05	.88	.78	.47	.09	.20
				KLA/ATP	.28	.22	.21	.24	.26	.22	.12
Mm.28174 1	KLA  ATP  ATP+KLA	94388259	Unknown	KLA	1.68	1.72	2.01	1.72	1.18	1.02	.92
				ATP	.95	1.00	.84	.71	.53	.74	.81
				KLA/ATP	1.79	1.76	1.40	1.17	.94	.74	.87
Mm.39071 7	KLA  ATP  ATP+KLA	77404401	Unknown	KLA	.86	.83	.88	1.03	1.07	1.12	.85
				ATP	.94	.88	1.33	1.11	1.09	1.69	1.47
				KLA/ATP	.78	.76	1.16	.94	1.13	1.52	1.17
Mm.57199	KLA  ATP  ATP+KLA	124256486	Unknown	KLA	.97	.97	.95	1.05	.96	.94	1.02
				ATP	.95	1.00	.96	.94	.97	1.05	.95
				KLA/ATP	.94	1.00	.86	1.02	.97	.96	.99
Mm.80682	KLA  ATP  ATP+KLA	94369627	Unknown	KLA	.96	1.00	.97	.97	1.07	1.05	.99
				ATP	.97	1.02	.98	1.01	1.01	1.06	.96
				KLA/ATP	1.00	.93	1.02	1.08	.98	.95	.97
Myc	KLA  ATP  ATP+KLA	NM_010849	myelocytomatosis oncogene (Myc), mRNA [NM_010849]	KLA	.38	.31	.45	.45	.49	.35	.33
				ATP	1.05	1.09	1.72	4.41	1.28	.45	.76
				KLA/ATP	.37	.30	.44	1.23	.34	.17	.19
Ncoa4	KLA  ATP  ATP+KLA	NM_001033988	nuclear receptor coactivator 4 (Ncoa4), transcript variant 2, mRNA [NM_001033988]	KLA	.60	.64	.65	.63	.80	.99	.84
				ATP	1.12	1.12	1.18	1.06	1.12	1.63	1.33
				KLA/ATP	.63	.63	.59	.58	.79	1.68	1.98
Nras	KLA  ATP  ATP+KLA	NM_010937	neuroblastoma ras oncogene (Nras), mRNA [NM_010937]	KLA	1.20	1.22	1.27	1.20	1.09	.91	.84
				ATP	.98	.91	.69	.61	.59	.67	.78
				KLA/ATP	1.22	1.14	.97	.79	.73	.61	.72
Ntrk1	KLA  ATP  ATP+KLA	NM_001033124	neurotrophic tyrosine kinase, receptor, type 1 (Ntrk1), mRNA [NM_001033124]	KLA	.95	.96	1.03	1.03	.95	1.01	1.02
				ATP	1.04	.98	.98	1.07	.99	1.01	1.02
				KLA/ATP	.97	1.03	1.10	1.02	1.05	1.00	.97
Pax8	KLA  ATP  ATP+KLA	AK032920	12 days embryo male wolffian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6720473A10 product:paired box gene 8, full insert sequence [AK032920]	KLA	.93	.91	.92	.91	1.02	1.07	1.04
				ATP	.98	1.06	.98	.99	1.00	1.02	.94
				KLA/ATP	.92	.95	.97	1.03	.98	.91	.89
Pax8	KLA  ATP  ATP+KLA	NM_011040	paired box gene 8 (Pax8), mRNA [NM_011040]	KLA	1.06	.96	1.07	1.01	1.03	.99	1.03
				ATP	1.10	.97	1.01	1.04	.97	1.00	1.00
				KLA/ATP	1.09	1.06	1.03	.94	.92	.92	.99
Pparg	KLA  ATP  ATP+KLA	NM_011146	peroxisome proliferator activated receptor gamma (Pparg), mRNA [NM_011146]	KLA	.32	.28	.31	.45	.38	.35	.49
				ATP	.96	1.01	1.28	1.65	1.83	.57	.77
				KLA/ATP	.30	.29	.36	.53	1.23	.72	.55
Ret	KLA  ATP  ATP+KLA	NM_009050	ret proto-oncogene (Ret), transcript variant 2, mRNA [NM_009050]	KLA	1.00	1.00	1.04	1.02	1.03	1.01	1.02
				ATP	1.02	.98	1.01	1.00	.99	1.01	1.01
				KLA/ATP	1.01	.97	1.02	1.01	1.00	1.00	.98
Rxra	KLA  ATP  ATP+KLA	NM_011305	retinoid X receptor alpha (Rxra), mRNA [NM_011305]	KLA	.53	.55	.50	.52	.54	.85	1.09
				ATP	.95	1.00	1.18	1.00	.82	1.20	1.65
				KLA/ATP	.57	.55	.58	.55	.67	1.07	1.57
Rxrb	KLA  ATP  ATP+KLA	NM_011306	retinoid X receptor beta (Rxrb), mRNA [NM_011306]	KLA	.71	.75	.75	.76	.83	.81	.89
				ATP	1.04	1.13	.94	1.20	1.13	.81	.75
				KLA/ATP	.80	.86	.72	.85	.83	.93	.92
Rxrg	KLA  ATP  ATP+KLA	NM_009107	retinoid X receptor gamma (Rxrg), mRNA [NM_009107]	KLA	.98	1.07	1.07	1.00	1.00	1.00	1.07
				ATP	1.02	1.03	1.06	1.06	1.11	1.01	.99
				KLA/ATP	.95	.97	1.05	1.05	1.09	.98	1.06
Tcf3	KLA  ATP  ATP+KLA	NM_001079822	transcription factor 3 (Tcf3), transcript variant 1, mRNA [NM_001079822]	KLA	1.03	.98	1.01	.98	.98	1.03	1.01
				ATP	1.00	1.02	1.00	1.06	1.10	1.07	.99
				KLA/ATP	1.07	.99	.97	1.05	1.05	1.11	.96
Tcf7	KLA  ATP  ATP+KLA	NM_009331	transcription factor 7, T-cell specific (Tcf7), mRNA [NM_009331]	KLA	1.00	1.01	1.03	1.00	.98	1.01	1.07
				ATP	.99	.98	1.02	1.03	1.03	1.00	1.01
				KLA/ATP	1.00	1.03	1.04	1.02	1.04	1.02	1.00
Tcf7l2	KLA  ATP  ATP+KLA	NM_009333	transcription factor 7-like 2, T-cell specific, HMG-box (Tcf7l2), mRNA [NM_009333]	KLA	1.01	1.12	1.11	1.31	1.06	1.34	1.29
				ATP	1.04	1.05	.94	1.06	.90	.81	.96
				KLA/ATP	1.08	1.11	1.05	1.18	1.04	1.02	1.42
Tfg	KLA  ATP  ATP+KLA	AK039139	adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230101M06 product:unclassifiable, full insert sequence [AK039139]	KLA	1.12	1.11	1.12	1.05	1.12	1.04	1.02
				ATP	.93	.85	.91	.95	.96	1.00	.90
				KLA/ATP	1.11	1.01	.92	.89	.97	1.03	.90
Tfg	KLA  ATP  ATP+KLA	NM_019678	Trk-fused gene (Tfg), mRNA [NM_019678]	KLA	1.81	1.71	2.04	2.24	1.93	1.42	1.01
				ATP	.94	.96	1.09	.95	.76	1.04	.84
				KLA/ATP	1.56	1.62	1.71	1.63	1.45	1.49	.85
Tpm3	KLA  ATP  ATP+KLA	NM_022314	tropomyosin 3, gamma (Tpm3), mRNA [NM_022314]	KLA	1.24	1.34	1.32	1.37	1.58	1.38	1.21
				ATP	1.11	1.25	.97	1.43	1.09	.80	1.10
				KLA/ATP	1.43	1.65	1.10	1.73	1.02	1.06	1.55
Tpr	KLA  ATP  ATP+KLA	NM_133780	translocated promoter region (Tpr), mRNA [NM_133780]	KLA	1.86	1.70	1.73	1.84	1.35	1.12	1.05
				ATP	1.03	.93	1.16	.85	.90	1.16	.66
				KLA/ATP	1.64	1.73	2.44	1.50	1.27	1.00	.83
Trp53	KLA  ATP  ATP+KLA	NM_011640	transformation related protein 53 (Trp53), mRNA [NM_011640]	KLA	1.25	1.37	1.11	.86	.72	.71	.95
				ATP	1.15	1.32	.90	1.85	1.26	.68	.70
				KLA/ATP	1.66	1.49	.80	1.76	.81	.65	.74