Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Prion diseases (mmu05020)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
Bax	KLA  ATP  ATP+KLA	NM_007527	Bcl2-associated X protein (Bax), mRNA [NM_007527]	KLA	1.08	1.14	1.10	1.14	1.17	1.06	.92
				ATP	1.06	1.05	1.02	1.25	1.26	.90	.86
				KLA/ATP	1.11	1.19	1.30	1.34	1.34	.87	.71
C1qa	KLA  ATP  ATP+KLA	NM_007572	complement component 1, q subcomponent, alpha polypeptide (C1qa), mRNA [NM_007572]	KLA	1.12	1.11	1.09	.94	1.11	1.12	1.31
				ATP	1.14	1.21	.88	1.16	.90	.67	.95
				KLA/ATP	1.12	1.23	.93	1.27	.86	.81	.91
C1qb	KLA  ATP  ATP+KLA	NM_009777	complement component 1, q subcomponent, beta polypeptide (C1qb), mRNA [NM_009777]	KLA	1.01	1.14	1.20	1.15	1.31	1.15	1.06
				ATP	1.16	1.20	.84	1.27	1.02	.70	.76
				KLA/ATP	1.29	1.36	.95	1.28	1.00	.97	.85
C1qc	KLA  ATP  ATP+KLA	NM_007574	complement component 1, q subcomponent, C chain (C1qc), mRNA [NM_007574]	KLA	1.03	.97	1.01	1.04	1.07	1.13	1.15
				ATP	1.07	1.06	.91	.94	.77	.62	.82
				KLA/ATP	1.08	1.02	.95	1.04	.76	.73	.66
C6	KLA  ATP  ATP+KLA	NM_016704	complement component 6 (C6), mRNA [NM_016704]	KLA	1.04	.97	1.04	1.06	.98	1.04	.95
				ATP	1.02	1.00	1.02	.96	1.01	.97	1.02
				KLA/ATP	.94	.95	1.07	1.05	.94	.94	.94
C8a	KLA  ATP  ATP+KLA	NM_146148	complement component 8, alpha polypeptide (C8a), mRNA [NM_146148]	KLA	1.02	1.02	.99	.96	1.06	1.03	1.01
				ATP	1.05	1.10	1.00	1.00	.99	1.03	.98
				KLA/ATP	.98	1.00	1.02	.97	.92	.93	1.03
C8b	KLA  ATP  ATP+KLA	NM_133882	complement component 8, beta subunit (C8b), mRNA [NM_133882]	KLA	.95	.96	.96	.95	1.00	.98	.98
				ATP	1.07	.96	1.03	1.03	.96	.96	.90
				KLA/ATP	.99	1.05	1.03	.99	.96	1.03	.95
C8g	KLA  ATP  ATP+KLA	NM_027062	complement component 8, gamma subunit (C8g), mRNA [NM_027062]	KLA	.89	.86	.85	.81	.74	.67	.90
				ATP	.94	.84	.79	.77	.63	.61	.82
				KLA/ATP	.85	.75	.74	.72	.62	.65	.81
C9	KLA  ATP  ATP+KLA	NM_013485	complement component 9 (C9), mRNA [NM_013485]	KLA	1.01	.95	1.00	1.03	1.01	1.05	1.07
				ATP	.96	.99	1.01	1.05	.98	1.04	1.06
				KLA/ATP	1.00	.97	.94	1.01	1.11	1.05	1.13
Casp12	KLA  ATP  ATP+KLA	NM_009808	caspase 12 (Casp12), mRNA [NM_009808]	KLA	6.56	6.38	7.54	6.85	5.36	2.61	1.46
				ATP	.99	.98	1.17	1.56	1.32	1.40	1.13
				KLA/ATP	6.27	6.52	5.79	5.68	3.74	2.21	1.78
Ccl5	KLA  ATP  ATP+KLA	M77747	rantes mRNA, complete cds. [M77747]	KLA	63.18	60.41	56.25	63.63	58.00	66.51	67.20
				ATP	.91	1.08	1.25	1.90	4.34	16.10	26.07
				KLA/ATP	55.92	63.34	72.91	65.68	70.81	71.97	81.34
Ccl5	KLA  ATP  ATP+KLA	NM_013653	chemokine (C-C motif) ligand 5 (Ccl5), mRNA [NM_013653]	KLA	40.31	35.22	27.92	38.59	29.29	37.98	28.83
				ATP	.86	.92	1.43	1.66	3.86	15.09	16.66
				KLA/ATP	32.14	31.72	47.19	35.89	42.00	46.15	43.89
Egr1	KLA  ATP  ATP+KLA	NM_007913	early growth response 1 (Egr1), mRNA [NM_007913]	KLA	1.00	.56	1.72	2.17	1.88	1.59	2.89
				ATP	8.02	5.01	71.67	137.15	83.52	19.89	1.19
				KLA/ATP	8.95	15.55	146.78	187.64	170.49	44.28	3.89
Elk1	KLA  ATP  ATP+KLA	AK082260	0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230030F12 product:ELK1, member of ETS oncogene family, full insert sequence. [AK082260]	KLA	1.02	1.01	1.01	.97	1.00	1.03	1.06
				ATP	1.02	1.07	1.06	1.03	1.02	1.02	1.00
				KLA/ATP	1.08	.99	.97	1.01	1.02	1.06	.95
Fyn	KLA  ATP  ATP+KLA	U70324	Fyn(T) (L-fyn(T)) mRNA, complete cds. [U70324]	KLA	1.23	1.27	1.31	1.27	1.31	.87	.48
				ATP	.88	.71	.66	.75	.90	1.28	.51
				KLA/ATP	1.12	1.01	.94	.84	1.25	1.51	.53
Hc	KLA  ATP  ATP+KLA	NM_010406	hemolytic complement (Hc), mRNA [NM_010406]	KLA	1.07	1.12	1.05	.98	1.12	1.12	1.08
				ATP	.96	.93	1.12	1.07	1.34	5.60	1.48
				KLA/ATP	1.05	1.18	1.12	1.05	1.13	3.40	4.37
Hspa1a	KLA  ATP  ATP+KLA	NM_010479	heat shock protein 1A (Hspa1a), mRNA [NM_010479]	KLA	7.88	6.99	4.47	5.18	7.81	11.47	4.14
				ATP	1.88	5.62	43.42	58.76	55.53	28.89	9.13
				KLA/ATP	7.40	7.62	28.23	54.12	70.14	43.09	22.49
Hspa1b	KLA  ATP  ATP+KLA	NM_010478	heat shock protein 1B (Hspa1b), mRNA [NM_010478]	KLA	5.01	4.73	3.77	3.62	4.81	6.53	3.12
				ATP	1.34	3.07	14.11	17.14	17.51	11.21	4.82
				KLA/ATP	5.04	5.15	11.63	19.94	20.84	15.79	9.30
Hspa5	KLA  ATP  ATP+KLA	NM_022310	heat shock protein 5 (Hspa5), mRNA [NM_022310]	KLA	1.58	1.55	1.47	1.58	1.81	1.30	1.22
				ATP	1.10	1.23	1.04	1.19	1.61	1.72	1.20
				KLA/ATP	1.80	1.85	1.54	1.66	1.67	1.80	.93
Il1a	KLA  ATP  ATP+KLA	NM_010554	interleukin 1 alpha (Il1a), mRNA [NM_010554]	KLA	32.45	35.22	31.30	20.95	28.57	18.36	19.02
				ATP	1.04	1.02	2.21	5.46	11.06	32.07	3.40
				KLA/ATP	32.02	41.20	35.12	46.91	28.76	42.72	57.80
Il1b	KLA  ATP  ATP+KLA	NM_008361	interleukin 1 beta (Il1b), mRNA [NM_008361]	KLA	149.78	133.59	100.91	116.58	86.48	89.37	64.72
				ATP	3.49	13.96	61.44	70.91	82.12	162.79	28.18
				KLA/ATP	130.32	139.00	219.12	148.17	165.44	172.57	146.98
Il6	KLA  ATP  ATP+KLA	NM_031168	interleukin 6 (Il6), mRNA [NM_031168]	KLA	352.99	378.70	276.81	168.47	59.99	18.66	8.27
				ATP	1.04	1.08	2.28	3.69	30.40	161.93	2.11
				KLA/ATP	334.28	528.66	###.##	935.86	302.45	355.36	99.65
Lamc1	KLA  ATP  ATP+KLA	J03484	gb|Mouse laminin B2 chain mRNA, complete cds [J03484]	KLA	1.14	1.01	1.04	.87	.82	.63	.75
				ATP	.99	1.09	1.07	1.14	1.36	2.38	.66
				KLA/ATP	1.04	1.10	.95	1.12	1.30	1.70	.68
Map2k1	KLA  ATP  ATP+KLA	NM_008927	mitogen-activated protein kinase kinase 1 (Map2k1), mRNA [NM_008927]	KLA	1.82	2.00	2.31	2.03	2.51	2.20	1.51
				ATP	.99	1.14	.81	.87	.90	1.57	1.11
				KLA/ATP	1.90	2.03	1.50	1.93	1.63	2.03	2.06
Map2k2	KLA  ATP  ATP+KLA	NM_023138	mitogen-activated protein kinase kinase 2 (Map2k2), mRNA [NM_023138]	KLA	.96	1.01	1.09	.99	1.11	1.15	1.42
				ATP	1.07	1.05	.74	.86	1.04	1.16	1.21
				KLA/ATP	1.14	1.03	.68	.78	.85	1.01	1.20
Mapk1	KLA  ATP  ATP+KLA	NM_001038663	mitogen-activated protein kinase 1 (Mapk1), transcript variant 2, mRNA [NM_001038663]	KLA	.97	1.03	.93	.86	.79	1.01	1.04
				ATP	.96	1.18	1.01	1.13	.84	1.04	1.16
				KLA/ATP	.99	.99	.84	.87	.63	.96	1.26
Mapk1	KLA  ATP  ATP+KLA	NM_011949	mitogen-activated protein kinase 1 (Mapk1), transcript variant 1, mRNA [NM_011949]	KLA	.88	.80	.80	.73	.75	.76	.65
				ATP	.97	.96	1.06	.88	.90	.68	.48
				KLA/ATP	.82	.81	.78	.65	.64	.64	.45
Mapk3	KLA  ATP  ATP+KLA	NM_011952	mitogen-activated protein kinase 3 (Mapk3), mRNA [NM_011952]	KLA	.81	.85	.88	.72	.79	.73	.90
				ATP	1.13	1.30	.92	1.48	1.08	.68	1.03
				KLA/ATP	1.01	1.01	.66	1.13	.77	.77	1.16
Mm.19763 8	KLA  ATP  ATP+KLA	22122666	Unknown	KLA	.93	1.02	.99	.99	1.03	1.02	1.04
				ATP	1.01	1.00	1.05	.88	.98	.98	1.01
				KLA/ATP	1.03	1.01	1.00	.97	1.00	1.07	.96
Mm.42163	KLA  ATP  ATP+KLA	157951683	Unknown	KLA	1.15	1.26	1.21	1.33	1.13	1.06	.99
				ATP	1.07	1.05	1.10	1.32	1.03	1.01	1.00
				KLA/ATP	1.19	1.16	1.15	1.47	1.11	1.12	.96
Mm.45825 9	KLA  ATP  ATP+KLA	116292181	Unknown	KLA	.84	.86	.91	.85	.98	.98	1.00
				ATP	1.05	1.06	.94	.95	1.00	.89	.89
				KLA/ATP	.92	.84	.87	.93	.91	.92	.82
Ncam1	KLA  ATP  ATP+KLA	NM_001113204	neural cell adhesion molecule 1 (Ncam1), transcript variant 3, mRNA [NM_001113204]	KLA	1.02	1.03	1.01	1.00	.95	.94	1.01
				ATP	1.02	.99	.98	1.07	.98	.97	1.03
				KLA/ATP	1.02	.99	1.03	1.01	1.01	1.00	.99
Ncam1	KLA  ATP  ATP+KLA	NM_010875	neural cell adhesion molecule 1 (Ncam1), transcript variant 2, mRNA [NM_010875]	KLA	1.02	1.02	1.02	1.02	1.02	1.00	.99
				ATP	1.02	1.03	1.01	1.00	1.01	1.00	1.00
				KLA/ATP	1.04	1.05	1.05	1.02	1.00	.99	.98
Ncam2	KLA  ATP  ATP+KLA	NM_010954	neural cell adhesion molecule 2 (Ncam2), transcript variant 2, mRNA [NM_010954]	KLA	1.03	1.00	1.01	.97	1.03	1.00	.99
				ATP	.98	1.04	.99	1.02	1.01	1.01	1.05
				KLA/ATP	.98	1.01	1.06	.97	1.01	.95	1.00
Notch1	KLA  ATP  ATP+KLA	NM_008714	Notch gene homolog 1 (Drosophila) (Notch1), mRNA [NM_008714]	KLA	7.88	6.28	6.84	5.57	5.54	2.82	1.81
				ATP	1.21	1.37	1.42	1.46	6.51	6.30	2.62
				KLA/ATP	6.74	8.26	8.17	7.73	8.90	5.34	4.14
Notch1	KLA  ATP  ATP+KLA	Z11886	gb|M.musculus notch-1 mRNA. [Z11886]	KLA	8.43	7.03	7.93	7.02	5.78	3.21	1.90
				ATP	1.08	1.18	1.52	1.48	7.39	7.40	2.89
				KLA/ATP	7.94	8.61	10.64	8.15	11.74	7.12	4.49
Prkaca	KLA  ATP  ATP+KLA	NM_008854	protein kinase, cAMP dependent, catalytic, alpha (Prkaca), mRNA [NM_008854]	KLA	.71	.74	.72	.70	.72	.84	.85
				ATP	1.05	.98	.89	.92	.76	.60	1.02
				KLA/ATP	.79	.74	.55	.65	.60	.65	.93
Prkacb	KLA  ATP  ATP+KLA	NM_011100	protein kinase, cAMP dependent, catalytic, beta (Prkacb), mRNA [NM_011100]	KLA	.69	.70	.66	.58	.51	.55	.59
				ATP	1.02	1.19	.97	1.01	.69	.38	.56
				KLA/ATP	.72	.73	.57	.62	.47	.41	.45
Prkx	KLA  ATP  ATP+KLA	NM_016979	protein kinase, X-linked (Prkx), mRNA [NM_016979]	KLA	3.61	3.79	4.67	4.66	4.85	4.19	1.43
				ATP	.98	.90	.63	.61	1.12	1.90	1.29
				KLA/ATP	3.56	3.36	2.62	2.06	2.26	2.87	2.31
Prnp	KLA  ATP  ATP+KLA	NM_011170	prion protein (Prnp), mRNA [NM_011170]	KLA	2.90	3.03	3.38	3.28	2.79	2.05	.44
				ATP	1.07	1.07	1.22	1.17	1.13	1.39	1.46
				KLA/ATP	2.90	3.15	3.61	3.51	3.12	3.26	1.80
Sod1	KLA  ATP  ATP+KLA	AK080908	4 days neonate male adipose cDNA, RIKEN full-length enriched library, clone:B430204E11 product:superoxide dismutase 1, soluble, full insert sequence [AK080908]	KLA	.70	.66	.60	.58	.66	.71	.86
				ATP	.93	.82	.78	.90	1.22	.91	.84
				KLA/ATP	.66	.64	.71	.75	.74	.73	.77
Sod1	KLA  ATP  ATP+KLA	NM_011434	superoxide dismutase 1, soluble (Sod1), mRNA [NM_011434]	KLA	.71	.80	.65	.90	.69	.53	.53
				ATP	1.03	.84	1.06	.96	1.27	1.34	.66
				KLA/ATP	.78	.79	1.12	.77	.96	.82	.52
Stip1	KLA  ATP  ATP+KLA	AK080936	4 days neonate male adipose cDNA, RIKEN full-length enriched library, clone:B430214C18 product:unclassifiable, full insert sequence [AK080936]	KLA	1.02	.97	1.01	1.02	.94	.97	1.01
				ATP	1.00	.96	.99	1.07	.97	.96	.99
				KLA/ATP	.99	.99	.99	.97	.95	1.00	.95
Stip1	KLA  ATP  ATP+KLA	NM_016737	stress-induced phosphoprotein 1 (Stip1), mRNA [NM_016737]	KLA	1.68	1.75	1.91	1.57	1.74	1.16	1.23
				ATP	1.18	1.27	1.05	1.48	1.30	.88	.89
				KLA/ATP	2.11	2.03	1.79	2.36	1.55	.95	.92