Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Carbohydrate digestion and absorption (mmu04973)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
2010204N 08Rik	KLA  ATP  ATP+KLA	NM_001081137	RIKEN cDNA 2010204N08 gene (2010204N08Rik), mRNA [NM_001081137]	KLA	.99	.98	1.00	.96	.98	.98	.99
				ATP	.96	.98	1.06	1.14	.98	.97	.99
				KLA/ATP	.98	1.05	1.06	1.04	.99	.98	1.94
AK078587	KLA  ATP  ATP+KLA	AK078587	11 days embryo gonad cDNA, RIKEN full-length enriched library, clone:7030411M21 product:unclassifiable, full insert sequence [AK078587]	KLA	1.37	1.28	1.13	1.06	1.15	1.31	1.22
				ATP	1.04	1.08	1.21	1.22	1.27	1.12	1.14
				KLA/ATP	1.48	1.66	1.97	1.26	1.17	1.03	1.28
Akt1	KLA  ATP  ATP+KLA	NM_009652	thymoma viral proto-oncogene 1 (Akt1), mRNA [NM_009652]	KLA	.80	.80	.75	.75	.71	.70	.82
				ATP	1.00	1.02	.76	.85	.76	.68	.84
				KLA/ATP	.82	.80	.64	.68	.67	.61	.72
Akt2	KLA  ATP  ATP+KLA	NM_007434	thymoma viral proto-oncogene 2 (Akt2), transcript variant 2, mRNA [NM_007434]	KLA	1.45	1.49	1.81	1.61	1.83	1.17	.92
				ATP	1.12	1.12	1.00	1.28	1.20	.94	1.06
				KLA/ATP	1.48	1.70	1.69	1.58	1.57	1.32	1.27
Akt3	KLA  ATP  ATP+KLA	NM_011785	thymoma viral proto-oncogene 3 (Akt3), mRNA [NM_011785]	KLA	3.42	3.45	5.31	5.16	4.65	3.80	2.12
				ATP	1.12	1.22	1.10	1.37	1.02	1.11	1.56
				KLA/ATP	3.72	4.17	4.62	4.64	2.74	2.05	3.82
Amy1	KLA  ATP  ATP+KLA	NM_007446	amylase 1, salivary (Amy1), transcript variant 1, mRNA [NM_007446]	KLA	1.03	1.01	1.14	1.07	1.06	1.13	1.16
				ATP	.99	.98	1.08	1.06	1.09	1.18	1.11
				KLA/ATP	1.06	1.10	1.19	1.13	1.16	1.43	1.21
Atp1a1	KLA  ATP  ATP+KLA	NM_144900	ATPase, Na+/K+ transporting, alpha 1 polypeptide (Atp1a1), mRNA [NM_144900]	KLA	.78	.94	.68	.81	.62	.55	.75
				ATP	1.02	1.05	.86	.85	1.77	2.54	1.11
				KLA/ATP	.83	.99	.80	.75	.91	1.15	.68
Atp1a2	KLA  ATP  ATP+KLA	NM_178405	ATPase, Na+/K+ transporting, alpha 2 polypeptide (Atp1a2), mRNA [NM_178405]	KLA	1.03	.98	1.03	1.05	1.03	.98	1.02
				ATP	1.03	.98	1.06	1.05	1.05	.93	1.07
				KLA/ATP	1.04	1.05	1.02	1.02	.98	.92	1.02
Atp1a3	KLA  ATP  ATP+KLA	AK053751	0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130306P09 product:ATPase, Na+/K+ transporting, alpha 3 polypeptide, full insert sequence. [AK053751]	KLA	.88	.87	.74	.80	.84	.88	.93
				ATP	.96	.83	.80	.88	.94	.89	1.15
				KLA/ATP	.89	.86	.79	.90	.93	.84	.92
Atp1a3	KLA  ATP  ATP+KLA	NM_144921	ATPase, Na+/K+ transporting, alpha 3 polypeptide (Atp1a3), mRNA [NM_144921]	KLA	.99	.87	.96	.86	.81	.61	.52
				ATP	1.22	1.21	1.16	1.38	1.27	.92	1.30
				KLA/ATP	.96	1.10	1.17	1.42	1.11	.91	.93
Atp1b1	KLA  ATP  ATP+KLA	NM_009721	ATPase, Na+/K+ transporting, beta 1 polypeptide (Atp1b1), mRNA [NM_009721]	KLA	.97	1.02	1.08	.98	.95	1.01	1.09
				ATP	1.07	1.05	1.09	1.09	1.02	1.17	1.11
				KLA/ATP	.99	.99	.93	1.02	1.00	1.07	1.04
Atp1b2	KLA  ATP  ATP+KLA	NM_013415	ATPase, Na+/K+ transporting, beta 2 polypeptide (Atp1b2), mRNA [NM_013415]	KLA	1.18	1.09	1.11	1.12	1.16	1.12	1.15
				ATP	.95	.98	.99	1.26	1.06	1.10	1.07
				KLA/ATP	1.15	1.16	1.09	1.19	1.27	1.13	1.02
Atp1b3	KLA  ATP  ATP+KLA	NM_007502	ATPase, Na+/K+ transporting, beta 3 polypeptide (Atp1b3), mRNA [NM_007502]	KLA	1.86	2.10	2.25	2.21	2.68	3.26	3.45
				ATP	1.08	1.09	.93	1.13	1.55	2.14	2.38
				KLA/ATP	1.95	2.10	1.84	2.34	2.20	2.96	4.69
Atp1b4	KLA  ATP  ATP+KLA	NM_133690	ATPase, (Na+)/K+ transporting, beta 4 polypeptide (Atp1b4), mRNA [NM_133690]	KLA	.99	1.02	1.03	1.01	.95	.90	1.00
				ATP	1.00	1.05	1.04	.98	1.07	.98	.97
				KLA/ATP	1.00	1.05	1.03	1.04	.96	.97	1.01
Cacna1d	KLA  ATP  ATP+KLA	NM_001083616	calcium channel, voltage-dependent, L type, alpha 1D subunit (Cacna1d), transcript variant 2, mRNA [NM_001083616]	KLA	1.57	1.58	2.50	3.62	4.55	2.93	.99
				ATP	1.12	.99	.97	.94	.75	1.71	1.48
				KLA/ATP	1.47	1.51	1.82	1.56	1.67	2.93	4.60
Cacna1d	KLA  ATP  ATP+KLA	NM_028981	calcium channel, voltage-dependent, L type, alpha 1D subunit (Cacna1d), transcript variant 1, mRNA [NM_028981]	KLA	1.20	1.26	1.43	1.62	2.07	1.66	1.00
				ATP	1.03	1.03	.97	.97	.93	1.20	1.26
				KLA/ATP	1.16	1.12	1.10	1.14	1.08	1.44	2.56
Fxyd2	KLA  ATP  ATP+KLA	NM_052823	FXYD domain-containing ion transport regulator 2 (Fxyd2), transcript variant b, mRNA [NM_052823]	KLA	1.07	.97	1.09	.98	1.02	.96	.83
				ATP	1.07	1.22	1.00	1.14	1.00	1.22	4.11
				KLA/ATP	1.06	1.11	.96	1.13	.98	1.01	1.02
G6pc	KLA  ATP  ATP+KLA	NM_008061	glucose-6-phosphatase, catalytic (G6pc), mRNA [NM_008061]	KLA	.96	.94	1.04	1.07	1.09	1.06	1.02
				ATP	.98	1.05	1.09	1.04	1.05	1.00	1.01
				KLA/ATP	1.03	1.05	1.06	.96	1.02	1.00	.99
G6pc2	KLA  ATP  ATP+KLA	NM_021331	glucose-6-phosphatase, catalytic, 2 (G6pc2), mRNA [NM_021331]	KLA	.99	1.03	1.00	.98	.95	1.02	.98
				ATP	.95	1.06	.97	1.08	1.16	1.26	1.04
				KLA/ATP	.94	.99	1.05	6.99	3.55	1.48	1.11
G6pc3	KLA  ATP  ATP+KLA	NM_175935	glucose 6 phosphatase, catalytic, 3 (G6pc3), mRNA [NM_175935]	KLA	.88	.89	.89	.80	.75	.68	.88
				ATP	.99	1.05	.95	1.14	.92	.64	.81
				KLA/ATP	.92	.90	.79	.94	.70	.62	.58
Hk1	KLA  ATP  ATP+KLA	J05277	gb|Mouse hexokinase mRNA, complete cds [J05277]	KLA	1.49	1.45	1.66	1.78	1.51	1.29	.99
				ATP	1.11	1.05	1.15	1.20	2.31	2.17	1.09
				KLA/ATP	1.63	1.51	1.70	1.47	1.94	1.92	1.40
Hk1	KLA  ATP  ATP+KLA	NM_010438	hexokinase 1 (Hk1), nuclear gene encoding mitochondrial protein, mRNA [NM_010438]	KLA	1.58	1.75	2.05	1.84	1.96	1.67	1.31
				ATP	1.06	1.25	1.01	1.49	2.23	1.79	1.20
				KLA/ATP	1.87	1.96	1.51	1.93	1.71	1.94	1.72
Hk2	KLA  ATP  ATP+KLA	NM_013820	hexokinase 2 (Hk2), mRNA [NM_013820]	KLA	4.09	4.09	3.17	2.37	1.53	1.62	2.02
				ATP	.98	.92	1.08	2.24	3.82	3.86	.97
				KLA/ATP	4.07	3.94	4.17	3.53	5.42	4.65	1.54
Hk3	KLA  ATP  ATP+KLA	NM_001033245	hexokinase 3 (Hk3), nuclear gene encoding mitochondrial protein, mRNA [NM_001033245]	KLA	1.52	1.68	1.94	1.85	2.21	2.89	1.98
				ATP	1.01	1.07	.87	.99	1.01	1.26	2.62
				KLA/ATP	1.63	1.74	1.67	1.69	1.44	2.01	3.53
Hkdc1	KLA  ATP  ATP+KLA	NM_145419	hexokinase domain containing 1 (Hkdc1), mRNA [NM_145419]	KLA	1.10	1.08	1.12	1.12	1.02	1.07	1.04
				ATP	.96	1.04	1.06	4.28	10.50	3.91	1.34
				KLA/ATP	.98	1.04	1.14	5.33	12.44	8.68	1.77
Lct	KLA  ATP  ATP+KLA	NM_001081078	lactase (Lct), mRNA [NM_001081078]	KLA	.93	.83	.71	.83	.89	.99	.84
				ATP	1.03	.98	.86	.92	.82	.85	.85
				KLA/ATP	.80	.88	.75	.78	.89	.87	.86
Mgam	KLA  ATP  ATP+KLA	AK033548	adult male colon cDNA, RIKEN full-length enriched library, clone:9030616M21 product:hypothetical protein, full insert sequence. [AK033548]	KLA	1.16	1.20	1.22	1.21	1.01	1.02	1.07
				ATP	1.01	1.01	1.11	2.86	5.71	5.58	1.53
				KLA/ATP	1.24	1.24	1.29	1.64	3.84	3.69	1.98
Mgam	KLA  ATP  ATP+KLA	XM_001481277	gb|PREDICTED: Mus musculus maltase-glucoamylase (Mgam), mRNA [XM_001481277]	KLA	1.03	1.04	1.03	1.04	.95	.98	1.06
				ATP	1.06	.94	1.05	1.42	2.38	2.12	1.16
				KLA/ATP	1.10	1.06	1.06	1.15	1.52	1.64	1.20
Mm.21312 8	KLA  ATP  ATP+KLA	141801344	Unknown	KLA	.96	.95	.83	.77	.52	.99	1.32
				ATP	.80	.82	1.09	.80	.83	1.19	1.46
				KLA/ATP	.78	.92	.98	.62	.71	.94	1.41
Mm.25237	KLA  ATP  ATP+KLA	141802859	Unknown	KLA	1.03	1.07	1.05	1.08	1.02	1.02	1.00
				ATP	.98	1.02	.89	.99	.99	1.03	1.09
				KLA/ATP	.92	.94	1.11	1.03	1.02	.97	1.09
Mm.25381 9	KLA  ATP  ATP+KLA	118130676	Unknown	KLA	1.81	1.88	1.96	1.62	1.89	2.44	1.56
				ATP	.92	.91	1.24	1.01	1.16	2.06	1.95
				KLA/ATP	1.62	1.86	1.86	1.41	1.89	2.37	1.97
Mm.26105 4	KLA  ATP  ATP+KLA	124487274	Unknown	KLA	.95	1.04	.97	.98	1.01	.94	1.10
				ATP	1.00	1.06	.94	1.07	1.01	1.00	.98
				KLA/ATP	1.04	.99	.93	1.01	1.11	1.07	1.04
Mm.26930	KLA  ATP  ATP+KLA	124487296	Unknown	KLA	1.16	1.07	1.03	1.13	1.13	1.32	1.25
				ATP	.99	1.00	1.05	1.24	1.38	1.37	1.06
				KLA/ATP	1.03	1.16	1.14	1.22	1.32	1.29	1.32
Mm.33401	KLA  ATP  ATP+KLA	149255058	Unknown	KLA	1.03	1.07	1.00	1.03	1.01	1.03	1.06
				ATP	1.12	.98	1.12	1.36	2.32	2.03	1.10
				KLA/ATP	1.03	1.00	.99	1.21	1.39	1.58	1.20
Pik3ca	KLA  ATP  ATP+KLA	ENSMUST00000108243	ens|Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K). [Source:Uniprot/SWISSPROT;Acc:P42337] [ENSMUST00000108243]	KLA	1.07	1.01	.91	.90	.98	.96	.86
				ATP	1.03	.87	1.12	.63	1.22	1.86	.60
				KLA/ATP	1.05	.82	.91	.61	1.17	1.26	.63
Pik3ca	KLA  ATP  ATP+KLA	NM_008839	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca), mRNA [NM_008839]	KLA	1.15	1.11	1.05	.82	.99	1.03	1.27
				ATP	.98	1.00	.79	.75	.96	1.32	1.10
				KLA/ATP	1.10	.98	.64	.72	.80	1.20	1.41
Pik3cb	KLA  ATP  ATP+KLA	NM_029094	phosphatidylinositol 3-kinase, catalytic, beta polypeptide (Pik3cb), mRNA [NM_029094]	KLA	1.06	1.06	1.03	.73	.68	.98	1.69
				ATP	1.04	1.21	.95	1.02	.85	.93	1.73
				KLA/ATP	1.15	1.27	.73	.83	.58	.81	1.81
Pik3cd	KLA  ATP  ATP+KLA	NM_008840	phosphatidylinositol 3-kinase catalytic delta polypeptide (Pik3cd), transcript variant 1, mRNA [NM_008840]	KLA	2.28	2.42	3.10	4.17	3.35	2.31	1.34
				ATP	1.02	.91	.99	.63	.30	.67	.80
				KLA/ATP	2.14	2.23	2.70	1.51	1.17	.85	.72
Pik3cd	KLA  ATP  ATP+KLA	U86587	phosphatidylinositol 3-kinase catalytic subunit p110 delta mRNA, complete cds. [U86587]	KLA	2.21	2.24	3.71	3.17	3.67	2.66	1.48
				ATP	1.00	1.03	.93	.96	.46	.75	.97
				KLA/ATP	2.27	2.32	1.97	2.02	1.01	.99	.98
Pik3cg	KLA  ATP  ATP+KLA	NM_020272	phosphoinositide-3-kinase, catalytic, gamma polypeptide (Pik3cg), mRNA [NM_020272]	KLA	.53	.53	.61	.64	.97	.86	.79
				ATP	1.01	1.13	.88	.89	.52	.53	.53
				KLA/ATP	.58	.53	.43	.60	.40	.43	.62
Pik3r1	KLA  ATP  ATP+KLA	NM_001077495	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) (Pik3r1), transcript variant 2, mRNA [NM_001077495]	KLA	1.05	1.07	1.03	1.00	1.01	1.20	.85
				ATP	.97	1.02	1.48	1.42	1.76	1.33	1.23
				KLA/ATP	1.11	1.12	1.06	1.17	1.24	.99	1.12
Pik3r2	KLA  ATP  ATP+KLA	NM_008841	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) (Pik3r2), mRNA [NM_008841]	KLA	.50	.50	.48	.43	.46	.66	.75
				ATP	.78	.68	.45	.43	.28	.57	1.37
				KLA/ATP	.49	.38	.32	.33	.38	.67	1.10
Pik3r3	KLA  ATP  ATP+KLA	NM_181585	phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) (Pik3r3), mRNA [NM_181585]	KLA	1.59	1.49	1.37	1.17	1.05	1.55	1.41
				ATP	1.12	1.00	1.33	1.70	2.01	2.37	2.02
				KLA/ATP	1.63	1.54	1.58	1.70	2.43	2.68	1.92
Pik3r5	KLA  ATP  ATP+KLA	NM_177320	phosphoinositide-3-kinase, regulatory subunit 5, p101 (Pik3r5), mRNA [NM_177320]	KLA	3.57	3.58	4.16	3.54	4.11	2.59	2.39
				ATP	1.08	1.08	.93	1.67	3.11	1.88	1.34
				KLA/ATP	3.91	3.70	3.30	3.80	2.70	2.04	3.00
Plcb2	KLA  ATP  ATP+KLA	NM_177568	phospholipase C, beta 2 (Plcb2), mRNA [NM_177568]	KLA	.70	.68	.64	.67	.65	.76	.88
				ATP	.95	.94	1.04	.94	.72	.57	1.19
				KLA/ATP	.69	.68	.72	.63	.65	.55	.70
Prkcb1	KLA  ATP  ATP+KLA	NM_008855	protein kinase C, beta 1 (Prkcb1), mRNA [NM_008855]	KLA	.92	.95	.93	.78	.77	1.08	1.83
				ATP	1.03	1.12	1.09	1.23	.90	2.08	.96
				KLA/ATP	.98	.99	.82	.89	.62	1.01	1.08
Slc2a2	KLA  ATP  ATP+KLA	NM_031197	solute carrier family 2 (facilitated glucose transporter), member 2 (Slc2a2), mRNA [NM_031197]	KLA	1.01	1.03	.97	1.00	1.01	1.02	1.04
				ATP	1.02	.97	1.07	1.00	1.00	1.03	1.00
				KLA/ATP	1.01	1.01	.95	1.00	1.05	1.02	1.01
Slc2a5	KLA  ATP  ATP+KLA	NM_019741	solute carrier family 2 (facilitated glucose transporter), member 5 (Slc2a5), mRNA [NM_019741]	KLA	.96	1.10	1.00	.95	.95	1.03	.95
				ATP	.99	1.00	.99	.99	1.28	1.15	.72
				KLA/ATP	.94	.94	.87	.91	1.47	1.41	1.00
Slc37a4	KLA  ATP  ATP+KLA	NM_008063	solute carrier family 37 (glucose-6-phosphate transporter), member 4 (Slc37a4), mRNA [NM_008063]	KLA	.61	.53	.54	.63	.64	.84	.82
				ATP	.95	.70	.60	.36	.29	.77	.94
				KLA/ATP	.53	.49	.46	.32	.33	.52	.72
Slc5a1	KLA  ATP  ATP+KLA	NM_019810	solute carrier family 5 (sodium/glucose cotransporter), member 1 (Slc5a1), mRNA [NM_019810]	KLA	1.02	1.02	1.03	1.04	.99	.93	1.06
				ATP	1.03	1.03	1.02	1.05	1.04	.98	.97
				KLA/ATP	1.02	.94	1.02	1.03	1.03	1.04	1.02
Tas1r2	KLA  ATP  ATP+KLA	NM_031873	taste receptor, type 1, member 2 (Tas1r2), mRNA [NM_031873]	KLA	.98	.97	1.09	1.07	1.04	1.07	1.11
				ATP	.96	1.00	1.06	2.63	2.51	1.41	1.19
				KLA/ATP	1.02	1.08	1.11	2.55	2.91	1.76	1.13
Tas1r3	KLA  ATP  ATP+KLA	NM_031872	taste receptor, type 1, member 3 (Tas1r3), mRNA [NM_031872]	KLA	1.11	1.20	1.23	1.21	1.17	1.44	1.13
				ATP	1.05	1.07	1.09	1.20	1.07	1.05	1.14
				KLA/ATP	1.18	1.18	1.03	1.19	1.18	1.10	1.25