Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Proximal tubule bicarbonate reclamation (mmu04964)

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Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
AK078587	KLA  ATP  ATP+KLA	AK078587	11 days embryo gonad cDNA, RIKEN full-length enriched library, clone:7030411M21 product:unclassifiable, full insert sequence [AK078587]	KLA	1.37	1.28	1.13	1.06	1.15	1.31	1.22
				ATP	1.04	1.08	1.21	1.22	1.27	1.12	1.14
				KLA/ATP	1.48	1.66	1.97	1.26	1.17	1.03	1.28
Aqp1	KLA  ATP  ATP+KLA	NM_007472	aquaporin 1 (Aqp1), mRNA [NM_007472]	KLA	1.01	.93	.93	.97	.95	.91	.72
				ATP	.98	1.01	.95	.97	.90	.92	.78
				KLA/ATP	.95	.92	.93	.90	.93	.90	.73
Atp1a1	KLA  ATP  ATP+KLA	NM_144900	ATPase, Na+/K+ transporting, alpha 1 polypeptide (Atp1a1), mRNA [NM_144900]	KLA	.78	.94	.68	.81	.62	.55	.75
				ATP	1.02	1.05	.86	.85	1.77	2.54	1.11
				KLA/ATP	.83	.99	.80	.75	.91	1.15	.68
Atp1a2	KLA  ATP  ATP+KLA	NM_178405	ATPase, Na+/K+ transporting, alpha 2 polypeptide (Atp1a2), mRNA [NM_178405]	KLA	1.03	.98	1.03	1.05	1.03	.98	1.02
				ATP	1.03	.98	1.06	1.05	1.05	.93	1.07
				KLA/ATP	1.04	1.05	1.02	1.02	.98	.92	1.02
Atp1a3	KLA  ATP  ATP+KLA	AK053751	0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130306P09 product:ATPase, Na+/K+ transporting, alpha 3 polypeptide, full insert sequence. [AK053751]	KLA	.88	.87	.74	.80	.84	.88	.93
				ATP	.96	.83	.80	.88	.94	.89	1.15
				KLA/ATP	.89	.86	.79	.90	.93	.84	.92
Atp1a3	KLA  ATP  ATP+KLA	NM_144921	ATPase, Na+/K+ transporting, alpha 3 polypeptide (Atp1a3), mRNA [NM_144921]	KLA	.99	.87	.96	.86	.81	.61	.52
				ATP	1.22	1.21	1.16	1.38	1.27	.92	1.30
				KLA/ATP	.96	1.10	1.17	1.42	1.11	.91	.93
Atp1b1	KLA  ATP  ATP+KLA	NM_009721	ATPase, Na+/K+ transporting, beta 1 polypeptide (Atp1b1), mRNA [NM_009721]	KLA	.97	1.02	1.08	.98	.95	1.01	1.09
				ATP	1.07	1.05	1.09	1.09	1.02	1.17	1.11
				KLA/ATP	.99	.99	.93	1.02	1.00	1.07	1.04
Atp1b2	KLA  ATP  ATP+KLA	NM_013415	ATPase, Na+/K+ transporting, beta 2 polypeptide (Atp1b2), mRNA [NM_013415]	KLA	1.18	1.09	1.11	1.12	1.16	1.12	1.15
				ATP	.95	.98	.99	1.26	1.06	1.10	1.07
				KLA/ATP	1.15	1.16	1.09	1.19	1.27	1.13	1.02
Atp1b3	KLA  ATP  ATP+KLA	NM_007502	ATPase, Na+/K+ transporting, beta 3 polypeptide (Atp1b3), mRNA [NM_007502]	KLA	1.86	2.10	2.25	2.21	2.68	3.26	3.45
				ATP	1.08	1.09	.93	1.13	1.55	2.14	2.38
				KLA/ATP	1.95	2.10	1.84	2.34	2.20	2.96	4.69
Atp1b4	KLA  ATP  ATP+KLA	NM_133690	ATPase, (Na+)/K+ transporting, beta 4 polypeptide (Atp1b4), mRNA [NM_133690]	KLA	.99	1.02	1.03	1.01	.95	.90	1.00
				ATP	1.00	1.05	1.04	.98	1.07	.98	.97
				KLA/ATP	1.00	1.05	1.03	1.04	.96	.97	1.01
Fxyd2	KLA  ATP  ATP+KLA	NM_052823	FXYD domain-containing ion transport regulator 2 (Fxyd2), transcript variant b, mRNA [NM_052823]	KLA	1.07	.97	1.09	.98	1.02	.96	.83
				ATP	1.07	1.22	1.00	1.14	1.00	1.22	4.11
				KLA/ATP	1.06	1.11	.96	1.13	.98	1.01	1.02
Gls2	KLA  ATP  ATP+KLA	NM_001033264	glutaminase 2 (liver, mitochondrial) (Gls2), nuclear gene encoding mitochondrial protein, mRNA [NM_001033264]	KLA	1.03	.98	1.02	.97	.98	.88	.80
				ATP	.94	1.01	1.04	1.08	1.26	1.20	.87
				KLA/ATP	.95	.98	1.15	1.02	1.29	.99	.87
Glud1	KLA  ATP  ATP+KLA	NM_008133	glutamate dehydrogenase 1 (Glud1), mRNA [NM_008133]	KLA	.70	.70	.63	.54	.52	.54	.59
				ATP	.96	.91	1.01	1.05	.96	.66	.47
				KLA/ATP	.67	.66	.61	.69	.70	.51	.27
Mdh1	KLA  ATP  ATP+KLA	AK077724	8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730556L21 product:unclassifiable, full insert sequence [AK077724]	KLA	.85	.75	.69	.67	.72	.81	.82
				ATP	.93	.83	.61	.59	.72	.72	.88
				KLA/ATP	.79	.76	.67	.58	.74	.74	.80
Mdh1	KLA  ATP  ATP+KLA	NM_008618	malate dehydrogenase 1, NAD (soluble) (Mdh1), mRNA [NM_008618]	KLA	.79	.72	.66	.66	.52	.49	.57
				ATP	.98	1.00	1.17	1.09	.96	.70	.66
				KLA/ATP	.70	.73	.92	.78	.76	.65	.52
Mm.29656 0	KLA  ATP  ATP+KLA	34328321	Unknown	KLA	1.41	1.37	1.50	1.48	1.35	1.43	1.21
				ATP	1.00	1.08	1.22	1.42	1.23	1.22	1.23
				KLA/ATP	1.41	1.48	1.57	1.61	1.50	1.56	1.51
Mm.30102	KLA  ATP  ATP+KLA	142348692	Unknown	KLA	1.04	1.04	.97	1.07	1.02	.93	.90
				ATP	1.06	.98	1.13	1.06	1.30	1.19	.78
				KLA/ATP	.94	1.05	1.13	1.05	1.24	1.12	.84
Mm.44046 5	KLA  ATP  ATP+KLA	164607131	Unknown	KLA	.65	.56	.59	.51	.33	.20	.24
				ATP	1.07	.90	1.30	2.88	3.61	4.46	1.07
				KLA/ATP	.60	.59	.95	2.38	2.99	2.31	.37
Pck2	KLA  ATP  ATP+KLA	NM_028994	phosphoenolpyruvate carboxykinase 2 (mitochondrial) (Pck2), nuclear gene encoding mitochondrial protein, mRNA [NM_028994]	KLA	.40	.37	.32	.28	.37	.56	.55
				ATP	.99	.96	.86	.94	1.02	.57	.77
				KLA/ATP	.40	.37	.31	.35	.42	.35	.46
Slc25a10	KLA  ATP  ATP+KLA	NM_013770	solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 (Slc25a10), nuclear gene encoding mitochondrial protein, mRNA [NM_013770]	KLA	1.41	1.49	1.55	1.46	1.88	2.09	2.13
				ATP	1.03	1.15	1.01	1.42	.89	.55	.73
				KLA/ATP	1.50	1.56	1.37	1.95	1.26	.90	1.31
Slc38a3	KLA  ATP  ATP+KLA	NM_023805	solute carrier family 38, member 3 (Slc38a3), mRNA [NM_023805]	KLA	1.18	1.02	1.01	1.03	1.04	1.04	.99
				ATP	1.01	.98	1.11	1.06	.99	1.05	1.06
				KLA/ATP	1.02	1.03	1.15	1.07	1.04	.96	1.06
Slc4a4	KLA  ATP  ATP+KLA	NM_018760	solute carrier family 4 (anion exchanger), member 4 (Slc4a4), mRNA [NM_018760]	KLA	1.02	1.03	1.01	1.02	.98	1.01	1.01
				ATP	1.03	.97	.94	1.00	1.02	1.00	1.02
				KLA/ATP	1.02	1.04	.85	1.03	.98	.97	1.00
Slc9a3	KLA  ATP  ATP+KLA	AK033564	adult male colon cDNA, RIKEN full-length enriched library, clone:9030624O13 product:SODIUM [AK033564]	KLA	.96	.94	.91	.97	.95	1.03	.99
				ATP	1.06	1.02	1.01	.95	.90	.95	1.08
				KLA/ATP	.97	.91	.93	.95	1.02	1.03	1.01