Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: SNARE interactions in vesicular transport (mmu04130)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
1110031B 06Rik	KLA  ATP  ATP+KLA	AK049330	ES cells cDNA, RIKEN full-length enriched library, clone:C330024G07 product:hypothetical Target SNARE coiled-coil domain containing protein, full insert sequence. [AK049330]	KLA	.61	.59	.55	.50	.45	.57	.81
				ATP	.93	.89	1.09	.91	.72	.60	1.60
				KLA/ATP	.57	.55	.66	.53	.61	.80	1.09
1110031B 06Rik	KLA  ATP  ATP+KLA	NM_144521	RIKEN cDNA 1110031B06 gene (1110031B06Rik), mRNA [NM_144521]	KLA	.68	.67	.63	.54	.51	.64	.96
				ATP	.96	1.06	.96	1.06	.77	.56	1.83
				KLA/ATP	.72	.69	.62	.65	.61	.78	1.31
Bet1	KLA  ATP  ATP+KLA	NM_009748	blocked early in transport 1 homolog (S. cerevisiae) (Bet1), mRNA [NM_009748]	KLA	.86	.84	.80	.80	.74	.77	1.03
				ATP	1.05	1.05	1.38	1.19	.88	.70	.98
				KLA/ATP	.75	.83	1.07	.90	.73	.74	.94
Bet1l	KLA  ATP  ATP+KLA	NM_018742	blocked early in transport 1 homolog (S. cerevisiae)-like (Bet1l), mRNA [NM_018742]	KLA	.92	.90	.93	1.18	1.39	1.36	1.19
				ATP	.94	.88	.68	.54	1.81	2.64	1.32
				KLA/ATP	.87	.84	.76	.70	2.33	2.27	1.94
Bnip1	KLA  ATP  ATP+KLA	AK170908	NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630208O05 product:BNIP1 protein homolog [Mus musculus], full insert sequence [AK170908]	KLA	1.00	.90	.99	.90	1.01	.98	1.02
				ATP	.89	.56	.78	.79	.80	.83	.94
				KLA/ATP	.84	.61	.73	.97	.97	.84	.96
Bnip1	KLA  ATP  ATP+KLA	NM_172149	BCL2/adenovirus E1B interacting protein 1, NIP1 (Bnip1), mRNA [NM_172149]	KLA	1.09	1.16	1.15	1.31	1.40	1.32	1.15
				ATP	1.05	1.02	1.12	1.45	.89	.91	1.08
				KLA/ATP	1.24	1.16	1.36	1.68	1.28	.92	1.20
Gosr1	KLA  ATP  ATP+KLA	NM_016810	golgi SNAP receptor complex member 1 (Gosr1), mRNA [NM_016810]	KLA	3.07	2.87	3.13	3.41	2.84	2.56	2.46
				ATP	1.07	1.01	1.06	1.02	1.22	2.72	2.79
				KLA/ATP	2.83	3.04	3.47	3.01	2.14	3.41	6.08
Gosr2	KLA  ATP  ATP+KLA	NM_019650	golgi SNAP receptor complex member 2 (Gosr2), mRNA [NM_019650]	KLA	1.90	2.01	1.77	1.67	1.60	1.85	1.63
				ATP	.96	1.01	1.11	1.40	1.87	1.98	1.95
				KLA/ATP	1.82	1.99	1.88	2.07	1.80	2.34	3.03
Sec22b	KLA  ATP  ATP+KLA	NM_011342	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (Sec22b), mRNA [NM_011342]	KLA	1.18	1.18	1.22	1.35	1.29	1.23	1.19
				ATP	1.06	1.03	1.09	1.02	1.34	2.84	1.53
				KLA/ATP	1.17	1.27	1.42	1.29	1.28	1.69	1.90
Snap23	KLA  ATP  ATP+KLA	NM_009222	synaptosomal-associated protein 23 (Snap23), mRNA [NM_009222]	KLA	1.27	1.33	1.46	1.36	1.33	1.07	.93
				ATP	.94	1.02	1.17	1.18	1.02	1.03	1.11
				KLA/ATP	1.14	1.32	1.43	1.37	1.13	1.05	1.20
Snap25	KLA  ATP  ATP+KLA	M22012	synaptosomal associated protein-25 (Snap25) mRNA, complete cds. [M22012]	KLA	1.04	1.01	1.00	1.06	1.05	1.07	.99
				ATP	.98	1.00	.98	.93	.97	1.04	1.01
				KLA/ATP	.97	1.00	1.09	1.03	.95	.99	1.03
Snap25	KLA  ATP  ATP+KLA	NM_011428	synaptosomal-associated protein 25 (Snap25), mRNA [NM_011428]	KLA	.99	1.00	.96	1.03	1.05	1.02	1.01
				ATP	.98	.99	1.01	1.06	1.02	1.09	.99
				KLA/ATP	.98	1.02	1.01	1.00	1.03	.98	1.07
Snap29	KLA  ATP  ATP+KLA	NM_023348	synaptosomal-associated protein 29 (Snap29), mRNA [NM_023348]	KLA	2.07	2.04	2.19	2.39	2.36	2.08	1.49
				ATP	1.08	1.12	1.07	1.11	1.62	1.87	1.87
				KLA/ATP	1.94	2.13	2.40	2.27	2.50	2.26	2.14
Stx11	KLA  ATP  ATP+KLA	XM_896683	gb|PREDICTED: Mus musculus syntaxin 11, transcript variant 3 (Stx11), mRNA [XM_896683]	KLA	21.87	21.50	20.19	14.63	15.14	9.41	5.76
				ATP	1.09	1.05	.92	4.12	18.67	18.59	5.03
				KLA/ATP	22.60	19.65	13.81	13.39	16.82	21.55	16.24
Stx16	KLA  ATP  ATP+KLA	NM_172675	syntaxin 16 (Stx16), transcript variant 1, mRNA [NM_172675]	KLA	2.70	2.79	3.42	2.84	3.09	2.83	2.83
				ATP	1.00	1.08	1.03	1.19	.64	1.39	2.35
				KLA/ATP	2.73	2.87	2.77	3.28	1.48	2.12	4.12
Stx17	KLA  ATP  ATP+KLA	NM_026343	syntaxin 17 (Stx17), mRNA [NM_026343]	KLA	.88	.83	.93	.86	.83	.90	.92
				ATP	1.00	.97	.88	.84	.54	.67	.83
				KLA/ATP	.96	.93	.84	.85	.64	.67	.87
Stx18	KLA  ATP  ATP+KLA	NM_026959	syntaxin 18 (Stx18), mRNA [NM_026959]	KLA	1.51	1.66	1.76	2.10	2.07	1.90	1.19
				ATP	1.04	.99	1.22	1.32	.82	1.47	1.30
				KLA/ATP	1.54	1.64	2.15	2.24	1.65	1.64	1.60
Stx19	KLA  ATP  ATP+KLA	NM_026588	syntaxin 19 (Stx19), mRNA [NM_026588]	KLA	.99	.95	1.02	.98	.96	1.03	.95
				ATP	1.05	1.06	1.00	.92	.97	.95	.96
				KLA/ATP	1.02	.98	1.01	.96	.98	.95	.97
Stx1a	KLA  ATP  ATP+KLA	NM_016801	syntaxin 1A (brain) (Stx1a), mRNA [NM_016801]	KLA	.84	.77	.70	.80	.75	.71	.82
				ATP	1.00	1.20	.92	.94	1.65	1.16	1.04
				KLA/ATP	.87	.76	.71	.82	1.14	.91	.88
Stx2	KLA  ATP  ATP+KLA	NM_007941	syntaxin 2 (Stx2), mRNA [NM_007941]	KLA	1.48	1.46	1.87	1.97	1.64	1.57	1.05
				ATP	.98	1.01	1.14	1.16	.89	.92	.92
				KLA/ATP	1.38	1.60	1.85	1.80	2.06	2.42	2.70
Stx3	KLA  ATP  ATP+KLA	AK137098	12 days embryo embryonic body between diaphragm region and neck cDNA, RIKEN full-length enriched library, clone:9430075B11 product:unclassifiable, full insert sequence. [AK137098]	KLA	.95	.87	.92	.89	.90	1.08	.98
				ATP	.94	1.00	.89	.91	.94	.97	.94
				KLA/ATP	.91	.97	.80	.76	.76	1.01	.78
Stx3	KLA  ATP  ATP+KLA	NM_001025307	syntaxin 3 (Stx3), transcript variant B, mRNA [NM_001025307]	KLA	1.02	1.02	1.29	1.22	1.18	1.29	1.12
				ATP	.95	.88	.84	.87	1.72	1.74	1.71
				KLA/ATP	1.03	.91	.93	.86	1.37	2.24	2.36
Stx3	KLA  ATP  ATP+KLA	NM_152220	syntaxin 3 (Stx3), transcript variant A, mRNA [NM_152220]	KLA	.97	.98	1.33	1.35	1.25	1.51	1.44
				ATP	1.22	1.22	1.02	1.25	3.83	2.92	3.59
				KLA/ATP	1.29	1.16	1.11	1.36	3.34	3.10	3.76
Stx4a	KLA  ATP  ATP+KLA	NM_009294	syntaxin 4A (placental) (Stx4a), mRNA [NM_009294]	KLA	1.23	1.37	1.43	1.38	1.46	1.26	1.31
				ATP	1.00	.90	.85	.95	.94	.72	1.19
				KLA/ATP	1.30	1.24	1.23	1.22	1.24	.71	1.14
Stx5a	KLA  ATP  ATP+KLA	NM_019829	syntaxin 5A (Stx5a), mRNA [NM_019829]	KLA	.97	.98	1.07	1.06	1.34	1.33	1.12
				ATP	1.03	.99	.73	.89	.91	1.33	1.17
				KLA/ATP	1.05	.96	.84	.99	.85	1.45	1.78
Stx6	KLA  ATP  ATP+KLA	NM_021433	syntaxin 6 (Stx6), mRNA [NM_021433]	KLA	2.73	2.79	2.82	2.62	2.13	1.45	1.23
				ATP	.97	.89	.67	.71	1.11	1.79	1.23
				KLA/ATP	3.00	2.63	1.69	1.51	1.08	1.48	1.90
Stx7	KLA  ATP  ATP+KLA	NM_016797	syntaxin 7 (Stx7), mRNA [NM_016797]	KLA	1.16	1.06	1.31	1.15	1.38	1.31	1.11
				ATP	1.15	1.02	.79	.72	.75	.70	1.15
				KLA/ATP	1.15	1.10	.95	.84	.88	.76	1.10
Stx8	KLA  ATP  ATP+KLA	AF093064	syntaxin-like protein 3I35 mRNA, complete cds. [AF093064]	KLA	1.01	1.10	1.05	1.20	1.26	1.61	1.32
				ATP	.93	.89	1.22	1.21	1.17	1.02	1.08
				KLA/ATP	1.03	1.18	1.41	1.41	1.65	1.64	1.52
Stx8	KLA  ATP  ATP+KLA	NM_018768	syntaxin 8 (Stx8), mRNA [NM_018768]	KLA	1.18	1.25	1.21	1.29	1.39	1.66	1.47
				ATP	.96	1.01	1.14	1.43	1.19	.96	1.13
				KLA/ATP	1.11	1.20	1.38	1.66	1.52	1.61	1.63
Use1	KLA  ATP  ATP+KLA	NM_025917	unconventional SNARE in the ER 1 homolog (S. cerevisiae) (Use1), transcript variant 1, mRNA [NM_025917]	KLA	.90	.87	.89	.80	.92	1.01	.93
				ATP	1.03	.94	1.11	1.15	.99	.83	.85
				KLA/ATP	.93	.89	.99	.98	.92	.89	1.00
Vamp1	KLA  ATP  ATP+KLA	NM_009496	vesicle-associated membrane protein 1 (Vamp1), transcript variant 1, mRNA [NM_009496]	KLA	.59	.59	.56	.63	.62	.67	.84
				ATP	.61	.45	.54	.53	.64	.67	1.21
				KLA/ATP	.65	.53	.58	.59	.55	.64	1.06
Vamp2	KLA  ATP  ATP+KLA	NM_009497	vesicle-associated membrane protein 2 (Vamp2), mRNA [NM_009497]	KLA	.99	1.02	1.03	1.07	1.34	1.25	1.58
				ATP	1.03	1.12	.88	1.22	.94	.99	1.62
				KLA/ATP	1.03	1.15	.82	1.10	.87	.93	1.86
Vamp3	KLA  ATP  ATP+KLA	NM_009498	vesicle-associated membrane protein 3 (Vamp3), mRNA [NM_009498]	KLA	1.20	1.23	1.47	1.36	1.53	1.52	1.10
				ATP	1.05	1.18	1.09	1.35	1.14	1.24	1.22
				KLA/ATP	1.39	1.38	1.09	1.61	1.18	1.44	1.63
Vamp4	KLA  ATP  ATP+KLA	NM_016796	vesicle-associated membrane protein 4 (Vamp4), mRNA [NM_016796]	KLA	.76	.72	.76	.76	1.01	1.17	1.60
				ATP	.99	.96	1.03	1.07	1.10	1.47	1.87
				KLA/ATP	.69	.71	.74	.82	.94	1.54	1.92
Vamp5	KLA  ATP  ATP+KLA	NM_016872	vesicle-associated membrane protein 5 (Vamp5), transcript variant 1, mRNA [NM_016872]	KLA	.89	.95	.93	.98	.94	1.02	1.06
				ATP	.99	1.00	1.17	1.17	.96	.80	1.07
				KLA/ATP	.94	.91	1.02	1.03	.99	.88	.89
Vamp7	KLA  ATP  ATP+KLA	NM_011515	vesicle-associated membrane protein 7 (Vamp7), mRNA [NM_011515]	KLA	1.10	1.05	.99	1.05	.86	.89	.83
				ATP	.87	.86	1.37	1.08	.90	.74	.57
				KLA/ATP	.93	1.02	1.21	1.03	.90	.69	.47
Vamp8	KLA  ATP  ATP+KLA	NM_016794	vesicle-associated membrane protein 8 (Vamp8), mRNA [NM_016794]	KLA	1.33	1.37	1.28	1.32	1.56	1.60	1.87
				ATP	1.08	1.15	1.02	1.32	1.12	.95	1.55
				KLA/ATP	1.32	1.45	1.25	1.69	1.47	1.42	2.39
Vti1a	KLA  ATP  ATP+KLA	AK014541	0 day neonate skin cDNA, RIKEN full-length enriched library, clone:4631433P05 product:vesicle transport through interaction with t-SNAREs 1 homolog, full insert sequence. [AK014541]	KLA	1.11	1.13	1.16	1.17	1.24	1.26	1.19
				ATP	1.04	1.03	.98	1.01	1.00	1.02	1.04
				KLA/ATP	1.13	1.04	1.01	1.05	.97	1.12	1.03
Vti1a	KLA  ATP  ATP+KLA	NM_016862	vesicle transport through interaction with t-SNAREs homolog 1A (yeast) (Vti1a), mRNA [NM_016862]	KLA	1.18	1.11	1.14	1.33	1.61	2.23	1.91
				ATP	1.07	1.05	.97	.86	.73	.58	.73
				KLA/ATP	1.03	1.15	1.48	1.13	.93	.76	.68
Vti1b	KLA  ATP  ATP+KLA	NM_016800	vesicle transport through interaction with t-SNAREs 1B homolog (Vti1b), mRNA [NM_016800]	KLA	.81	.85	.76	.78	.87	1.05	1.27
				ATP	.94	.95	1.02	.92	.92	.72	1.11
				KLA/ATP	.77	.79	.70	.78	.81	.69	.77
Ykt6	KLA  ATP  ATP+KLA	NM_019661	YKT6 homolog (S. Cerevisiae) (Ykt6), mRNA [NM_019661]	KLA	1.00	1.06	.98	1.01	1.06	1.43	1.32
				ATP	.96	1.02	.98	.96	1.45	2.30	3.23
				KLA/ATP	.99	1.03	.96	.90	1.17	2.01	3.77