Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Protein export (mmu03060)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
Hspa5	KLA  ATP  ATP+KLA	NM_022310	heat shock protein 5 (Hspa5), mRNA [NM_022310]	KLA	1.58	1.55	1.47	1.58	1.81	1.30	1.22
				ATP	1.10	1.23	1.04	1.19	1.61	1.72	1.20
				KLA/ATP	1.80	1.85	1.54	1.66	1.67	1.80	.93
Immp1l	KLA  ATP  ATP+KLA	NM_028260	IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) (Immp1l), nuclear gene encoding mitochondrial protein, mRNA [NM_028260]	KLA	1.14	1.12	1.05	1.19	1.04	1.13	1.36
				ATP	.92	.92	1.40	1.19	1.07	.99	.96
				KLA/ATP	.99	1.11	1.44	1.17	1.08	1.04	1.06
Immp2l	KLA  ATP  ATP+KLA	NM_053122	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) (Immp2l), nuclear gene encoding mitochondrial protein, mRNA [NM_053122]	KLA	1.17	1.23	1.18	1.18	1.00	.76	.50
				ATP	.98	.89	1.35	1.21	1.30	.95	.37
				KLA/ATP	1.19	1.18	1.54	1.18	1.19	.86	.40
Mm.12848	KLA  ATP  ATP+KLA	149263137	Unknown	KLA	.99	.98	.89	.97	.95	.87	.94
				ATP	.99	.97	.84	.90	.83	.91	.85
				KLA/ATP	.91	.96	.94	.90	.89	.90	.80
Oxa1l	KLA  ATP  ATP+KLA	NM_026936	oxidase assembly 1-like (Oxa1l), mRNA [NM_026936]	KLA	.76	.78	.83	.86	.91	.98	1.00
				ATP	1.08	1.11	.94	.99	.84	.74	.88
				KLA/ATP	.85	.85	.80	.81	.76	.86	.89
Sec11a	KLA  ATP  ATP+KLA	NM_019951	SEC11 homolog A (S. cerevisiae) (Sec11a), mRNA [NM_019951]	KLA	.72	.81	.67	.75	.70	.85	1.03
				ATP	.94	.87	1.12	.91	1.04	1.20	1.01
				KLA/ATP	.70	.69	.87	.69	.79	.89	.79
Sec11c	KLA  ATP  ATP+KLA	NM_025468	SEC11 homolog C (S. cerevisiae) (Sec11c), mRNA [NM_025468]	KLA	1.15	1.13	1.03	.98	.89	.73	.72
				ATP	1.13	1.14	1.28	1.29	1.52	1.20	1.17
				KLA/ATP	1.06	1.17	1.26	1.26	1.10	.99	.85
Sec61a1	KLA  ATP  ATP+KLA	NM_016906	Sec61 alpha 1 subunit (S. cerevisiae) (Sec61a1), mRNA [NM_016906]	KLA	.97	.99	.99	1.04	1.05	1.07	1.21
				ATP	1.03	1.02	.87	.94	.94	.96	1.23
				KLA/ATP	.98	.99	.90	.96	.77	.89	1.02
Sec61a2	KLA  ATP  ATP+KLA	NM_021305	Sec61, alpha subunit 2 (S. cerevisiae) (Sec61a2), mRNA [NM_021305]	KLA	.86	.92	.91	.78	.84	.85	1.21
				ATP	1.05	1.08	.72	.79	1.33	.93	1.13
				KLA/ATP	.91	.92	.68	.79	.88	1.03	1.02
Sec61b	KLA  ATP  ATP+KLA	NM_024171	Sec61 beta subunit (Sec61b), mRNA [NM_024171]	KLA	.95	.88	.80	.87	.74	.76	.93
				ATP	.93	.97	1.17	1.20	1.01	.84	.89
				KLA/ATP	.81	.89	1.04	.99	1.00	.82	.56
Sec61g	KLA  ATP  ATP+KLA	NM_011343	SEC61, gamma subunit (Sec61g), transcript variant 1, mRNA [NM_011343]	KLA	1.19	1.06	1.12	1.34	1.13	1.11	1.10
				ATP	1.09	.98	1.22	1.13	1.22	1.39	1.01
				KLA/ATP	1.16	1.19	1.63	1.25	1.58	1.41	.96
Sec63	KLA  ATP  ATP+KLA	NM_153055	SEC63-like (S. cerevisiae) (Sec63), mRNA [NM_153055]	KLA	1.08	1.10	1.04	.98	.87	.78	.72
				ATP	1.02	.95	1.00	.87	.90	.81	.72
				KLA/ATP	1.01	1.11	1.17	.99	.85	.67	.48
Spcs1	KLA  ATP  ATP+KLA	NM_026911	signal peptidase complex subunit 1 homolog (S. cerevisiae) (Spcs1), mRNA [NM_026911]	KLA	.97	1.04	.97	.94	.97	.99	.99
				ATP	1.05	1.11	1.02	1.13	1.09	1.03	1.17
				KLA/ATP	1.05	1.03	.89	1.11	.97	1.06	1.17
Spcs2	KLA  ATP  ATP+KLA	NM_025668	signal peptidase complex subunit 2 homolog (S. cerevisiae) (Spcs2), mRNA [NM_025668]	KLA	.97	.86	.82	.87	.81	.89	1.03
				ATP	.99	1.01	1.17	1.21	1.07	1.05	1.08
				KLA/ATP	.84	.91	1.04	1.01	1.07	1.02	.90
Spcs3	KLA  ATP  ATP+KLA	NM_029701	signal peptidase complex subunit 3 homolog (S. cerevisiae) (Spcs3), mRNA [NM_029701]	KLA	.85	.87	.79	.69	.67	.65	1.01
				ATP	1.05	1.13	1.05	1.00	.85	.73	.78
				KLA/ATP	.85	.88	.76	.78	.58	.51	.53
Srp14	KLA  ATP  ATP+KLA	NM_009273	signal recognition particle 14 (Srp14), mRNA [NM_009273]	KLA	.85	.84	.89	.95	.82	.80	.84
				ATP	1.06	.99	1.23	1.17	1.18	.97	.96
				KLA/ATP	.91	.96	1.14	.94	1.06	.99	.82
Srp19	KLA  ATP  ATP+KLA	NM_025527	signal recognition particle 19 (Srp19), mRNA [NM_025527]	KLA	.90	.87	.86	.95	.89	.97	1.04
				ATP	.89	.83	1.20	.91	.98	1.45	1.14
				KLA/ATP	.76	.79	1.08	.75	.99	1.21	.93
Srp54a	KLA  ATP  ATP+KLA	NM_011899	signal recognition particle 54a (Srp54a), mRNA [NM_011899]	KLA	1.43	1.55	1.47	1.28	1.14	1.06	1.20
				ATP	.97	.91	.75	.73	.89	1.03	.99
				KLA/ATP	1.46	1.42	1.18	.95	.92	.96	.89
Srp68	KLA  ATP  ATP+KLA	NM_146032	signal recognition particle 68 (Srp68), mRNA [NM_146032]	KLA	1.00	1.04	1.10	.91	.96	.89	.92
				ATP	1.12	1.08	.99	1.19	1.28	1.23	1.31
				KLA/ATP	1.05	1.15	1.11	1.02	.89	.92	1.07
Srp72	KLA  ATP  ATP+KLA	NM_025691	signal recognition particle 72 (Srp72), mRNA [NM_025691]	KLA	1.18	1.18	1.01	1.00	1.12	1.03	1.34
				ATP	1.05	1.08	.95	1.16	.96	.77	.94
				KLA/ATP	1.16	1.16	.88	1.21	.80	.75	.77
Srp9	KLA  ATP  ATP+KLA	AK003606	18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110011E08 product:unclassifiable, full insert sequence. [AK003606]	KLA	1.02	.90	.78	1.06	1.00	.92	.98
				ATP	.72	.66	.60	.77	1.18	1.28	.89
				KLA/ATP	.71	.74	.73	.94	1.23	1.08	1.00
Srp9	KLA  ATP  ATP+KLA	NM_012058	signal recognition particle 9 (Srp9), mRNA [NM_012058]	KLA	.93	.91	.87	1.05	.98	.97	1.10
				ATP	.99	.93	1.16	1.06	1.16	1.39	1.31
				KLA/ATP	.84	.91	1.11	1.04	1.08	1.30	1.19
Srpr	KLA  ATP  ATP+KLA	NM_026130	signal recognition particle receptor (docking protein) (Srpr), mRNA [NM_026130]	KLA	1.29	1.44	1.44	1.44	1.64	1.67	1.48
				ATP	1.00	1.26	.87	1.19	.99	1.12	1.35
				KLA/ATP	1.44	1.72	1.13	1.73	1.14	1.43	1.73
Srprb	KLA  ATP  ATP+KLA	NM_009275	signal recognition particle receptor, B subunit (Srprb), mRNA [NM_009275]	KLA	.93	1.00	.94	.89	.83	.79	1.21
				ATP	1.07	1.18	.99	1.19	1.02	.94	1.12
				KLA/ATP	1.03	1.08	.90	1.10	.83	.88	.90
Tloc1	KLA  ATP  ATP+KLA	NM_027016	translocation protein 1 (Tloc1), mRNA [NM_027016]	KLA	1.04	1.09	1.05	1.01	.94	.86	.92
				ATP	1.05	1.10	1.11	1.03	.87	.76	.73
				KLA/ATP	1.06	1.12	1.04	1.07	.88	.70	.54