Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: DNA replication (mmu03030)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
AK047274	KLA  ATP  ATP+KLA	AK047274	10 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:B930044L01 product:unclassifiable, full insert sequence. [AK047274]	KLA	.92	.85	.90	.92	.98	.93	.92
				ATP	1.03	1.11	1.07	.90	.89	.93	.94
				KLA/ATP	.89	.96	.94	.84	.93	.92	.92
Dna2	KLA  ATP  ATP+KLA	AK129051	mRNA for mKIAA0083 protein [AK129051]	KLA	.46	.34	.34	.39	.34	.34	.34
				ATP	1.10	1.15	.89	.65	.40	.40	.56
				KLA/ATP	.40	.32	.45	.39	.39	.37	.40
Dna2	KLA  ATP  ATP+KLA	NM_177372	DNA replication helicase 2 homolog (yeast) (Dna2), mRNA [NM_177372]	KLA	.47	.47	.47	.45	.43	.52	.44
				ATP	1.01	.98	.85	.67	.47	.49	.60
				KLA/ATP	.46	.43	.50	.47	.48	.48	.47
Fen1	KLA  ATP  ATP+KLA	NM_007999	flap structure specific endonuclease 1 (Fen1), mRNA [NM_007999]	KLA	.37	.38	.37	.34	.41	.57	.44
				ATP	.98	1.04	.81	.78	.74	.72	.53
				KLA/ATP	.42	.37	.33	.38	.60	1.03	.43
Lig1	KLA  ATP  ATP+KLA	NM_010715	ligase I, DNA, ATP-dependent (Lig1), transcript variant 2, mRNA [NM_010715]	KLA	.53	.54	.51	.42	.30	.28	.27
				ATP	.97	.93	1.02	.96	.73	.29	.30
				KLA/ATP	.55	.50	.57	.48	.43	.26	.20
Mcm2	KLA  ATP  ATP+KLA	NM_008564	minichromosome maintenance deficient 2 mitotin (S. cerevisiae) (Mcm2), mRNA [NM_008564]	KLA	.24	.24	.17	.13	.12	.35	.23
				ATP	1.00	1.01	1.06	1.02	.54	.18	.33
				KLA/ATP	.28	.23	.20	.21	.17	.19	.11
Mcm3	KLA  ATP  ATP+KLA	AK088142	2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430004P22 product:mini chromosome maintenance deficient (S. cerevisiae), full insert sequence [AK088142]	KLA	.33	.29	.27	.22	.20	.37	.31
				ATP	.88	.90	1.19	1.06	.67	.29	.30
				KLA/ATP	.30	.28	.33	.30	.25	.22	.13
Mcm3	KLA  ATP  ATP+KLA	NM_008563	minichromosome maintenance deficient 3 (S. cerevisiae) (Mcm3), mRNA [NM_008563]	KLA	.37	.36	.32	.24	.22	.38	.34
				ATP	1.01	1.07	1.03	1.17	.75	.30	.32
				KLA/ATP	.36	.35	.35	.37	.27	.21	.15
Mcm4	KLA  ATP  ATP+KLA	AK083618	9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030054K02 product:mini chromosome maintenance deficient 4 homolog (S. cerevisiae), full insert sequence. [AK083618]	KLA	.94	.94	.95	.94	.98	.95	.94
				ATP	.93	.91	.92	.93	1.06	.93	1.02
				KLA/ATP	.95	.95	.95	.91	.93	.95	.95
Mcm4	KLA  ATP  ATP+KLA	NM_008565	minichromosome maintenance deficient 4 homolog (S. cerevisiae) (Mcm4), mRNA [NM_008565]	KLA	.37	.37	.29	.20	.18	.37	.25
				ATP	.95	.97	1.11	.88	.67	.31	.28
				KLA/ATP	.36	.33	.35	.27	.25	.32	.14
Mcm5	KLA  ATP  ATP+KLA	NM_008566	minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) (Mcm5), mRNA [NM_008566]	KLA	.48	.49	.44	.34	.28	.34	.30
				ATP	1.04	1.09	.86	1.11	.67	.32	.29
				KLA/ATP	.52	.50	.37	.50	.35	.28	.23
Mcm6	KLA  ATP  ATP+KLA	NM_008567	minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) (Mcm6), mRNA [NM_008567]	KLA	.59	.54	.53	.54	.37	.45	.24
				ATP	.99	.89	1.17	.80	.58	.16	.23
				KLA/ATP	.51	.53	.65	.43	.41	.17	.08
Mcm7	KLA  ATP  ATP+KLA	NM_008568	minichromosome maintenance deficient 7 (S. cerevisiae) (Mcm7), mRNA [NM_008568]	KLA	.31	.31	.25	.16	.12	.21	.14
				ATP	1.08	1.10	1.01	1.01	.59	.21	.16
				KLA/ATP	.36	.29	.26	.26	.18	.16	.09
Mm.29073	KLA  ATP  ATP+KLA	146141223	Unknown	KLA	.48	.44	.52	.52	.40	.48	.44
				ATP	1.03	.81	1.38	1.13	.59	.41	.38
				KLA/ATP	.45	.50	.74	.47	.37	.41	.31
Mm.38683 5	KLA  ATP  ATP+KLA	21703947	Unknown	KLA	.41	.36	.37	.36	.33	.47	.36
				ATP	1.06	.92	1.29	1.00	.55	.46	.34
				KLA/ATP	.41	.36	.50	.37	.32	.38	.24
Mm.42112 9	KLA  ATP  ATP+KLA	133892806	Unknown	KLA	.56	.53	.50	.43	.25	.23	.19
				ATP	.91	.89	1.16	.93	.74	.27	.22
				KLA/ATP	.52	.48	.64	.47	.43	.21	.14
Pcna	KLA  ATP  ATP+KLA	NM_011045	proliferating cell nuclear antigen (Pcna), mRNA [NM_011045]	KLA	.70	.69	.73	.56	.46	.66	.55
				ATP	.98	.95	1.12	.81	.74	.49	.92
				KLA/ATP	.69	.66	.78	.60	.63	.59	.62
Pola1	KLA  ATP  ATP+KLA	NM_008892	polymerase (DNA directed), alpha 1 (Pola1), mRNA [NM_008892]	KLA	.72	.68	.59	.56	.27	.19	.21
				ATP	.81	.97	1.41	1.22	.71	.29	.16
				KLA/ATP	.58	.70	.81	.56	.39	.27	.12
Pola2	KLA  ATP  ATP+KLA	BC006945	polymerase (DNA directed), alpha 2, mRNA (cDNA clone MGC:11533 IMAGE:3602559), complete cds [BC006945]	KLA	.74	.76	.70	.74	.88	.91	.98
				ATP	.99	1.03	.83	.78	.96	.76	.92
				KLA/ATP	.67	.69	.65	.77	.88	.83	1.02
Pola2	KLA  ATP  ATP+KLA	NM_008893	polymerase (DNA directed), alpha 2 (Pola2), mRNA [NM_008893]	KLA	.82	.76	.91	.72	.73	.74	.85
				ATP	1.12	1.12	.88	1.20	.86	.82	.64
				KLA/ATP	.89	.84	.75	.84	.78	.91	1.16
Pold1	KLA  ATP  ATP+KLA	NM_011131	polymerase (DNA directed), delta 1, catalytic subunit (Pold1), mRNA [NM_011131]	KLA	.24	.21	.20	.18	.18	.29	.36
				ATP	1.05	1.05	.96	.99	.52	.26	.32
				KLA/ATP	.26	.22	.21	.22	.16	.17	.18
Pold2	KLA  ATP  ATP+KLA	NM_008894	polymerase (DNA directed), delta 2, regulatory subunit (Pold2), mRNA [NM_008894]	KLA	.77	.83	.69	.68	.59	.49	.57
				ATP	1.05	1.09	.97	1.24	.89	.44	.43
				KLA/ATP	.79	.78	.70	.84	.60	.41	.30
Pold3	KLA  ATP  ATP+KLA	NM_133692	polymerase (DNA-directed), delta 3, accessory subunit (Pold3), mRNA [NM_133692]	KLA	1.14	1.07	1.22	1.22	1.12	1.40	1.10
				ATP	.99	.95	1.17	.89	1.46	1.74	1.55
				KLA/ATP	1.01	1.08	1.54	1.28	1.86	2.34	2.11
Pold4	KLA  ATP  ATP+KLA	NM_027196	polymerase (DNA-directed), delta 4 (Pold4), mRNA [NM_027196]	KLA	.81	.88	.80	.78	.85	1.04	1.40
				ATP	.97	1.07	1.12	1.37	1.19	.86	1.27
				KLA/ATP	.85	.90	.89	1.07	.90	.94	1.62
Pole	KLA  ATP  ATP+KLA	AK086490	15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930032B21 product:DNA polymerase epsilon, full insert sequence. [AK086490]	KLA	1.00	1.00	1.04	.96	.94	.99	1.04
				ATP	.97	.95	.91	.95	.97	1.06	.95
				KLA/ATP	.96	.93	1.00	1.01	1.08	1.02	1.01
Pole	KLA  ATP  ATP+KLA	NM_011132	polymerase (DNA directed), epsilon (Pole), mRNA [NM_011132]	KLA	.50	.44	.38	.31	.25	.21	.17
				ATP	1.12	1.03	1.28	.89	.68	.30	.16
				KLA/ATP	.45	.44	.56	.38	.30	.21	.14
Pole2	KLA  ATP  ATP+KLA	NM_011133	polymerase (DNA directed), epsilon 2 (p59 subunit) (Pole2), mRNA [NM_011133]	KLA	.25	.24	.22	.21	.21	.37	.34
				ATP	.93	.98	1.11	1.00	.36	.30	.35
				KLA/ATP	.22	.22	.29	.30	.26	.28	.19
Pole3	KLA  ATP  ATP+KLA	BC034004	polymerase (DNA directed), epsilon 3 (p17 subunit), mRNA (cDNA clone IMAGE:5117478) [BC034004]	KLA	.69	.72	.63	.69	.68	.81	.61
				ATP	.91	.86	1.29	.96	.81	.94	.51
				KLA/ATP	.62	.54	.85	.64	.70	.75	.44
Pole3	KLA  ATP  ATP+KLA	NM_021498	polymerase (DNA directed), epsilon 3 (p17 subunit) (Pole3), mRNA [NM_021498]	KLA	1.14	1.14	1.23	1.36	1.18	1.15	1.01
				ATP	1.02	.98	1.17	1.44	1.40	1.27	1.25
				KLA/ATP	1.20	1.24	1.58	1.57	1.60	1.25	1.23
Pole4	KLA  ATP  ATP+KLA	NM_025882	polymerase (DNA-directed), epsilon 4 (p12 subunit) (Pole4), mRNA [NM_025882]	KLA	1.11	1.15	1.15	1.22	1.19	1.31	1.26
				ATP	1.00	.99	1.36	1.32	1.34	1.19	.98
				KLA/ATP	1.02	1.15	1.58	1.47	1.52	1.10	.85
Prim1	KLA  ATP  ATP+KLA	NM_008921	DNA primase, p49 subunit (Prim1), mRNA [NM_008921]	KLA	.28	.26	.22	.18	.14	.24	.28
				ATP	.88	.80	1.35	.98	.50	.25	.26
				KLA/ATP	.22	.22	.33	.23	.20	.16	.10
Prim2	KLA  ATP  ATP+KLA	NM_008922	DNA primase, p58 subunit (Prim2), mRNA [NM_008922]	KLA	.72	.68	.61	.54	.39	.52	.50
				ATP	.88	.76	.77	.64	.39	.47	.44
				KLA/ATP	.63	.59	.59	.44	.34	.46	.33
Rfc1	KLA  ATP  ATP+KLA	NM_011258	replication factor C (activator 1) 1 (Rfc1), mRNA [NM_011258]	KLA	.37	.35	.39	.42	.46	.67	.75
				ATP	.96	.95	1.13	.76	.45	.40	.62
				KLA/ATP	.36	.38	.42	.30	.29	.38	.36
Rfc2	KLA  ATP  ATP+KLA	NM_020022	replication factor C (activator 1) 2 (Rfc2), mRNA [NM_020022]	KLA	.51	.52	.53	.57	.61	.86	.75
				ATP	.96	.91	1.11	1.11	.70	.35	.86
				KLA/ATP	.51	.50	.62	.54	.57	.56	.76
Rfc3	KLA  ATP  ATP+KLA	NM_027009	replication factor C (activator 1) 3 (Rfc3), mRNA [NM_027009]	KLA	1.71	1.88	2.23	1.86	1.17	1.37	.82
				ATP	.93	.90	1.00	.94	.72	.77	.68
				KLA/ATP	1.74	1.98	2.39	2.16	1.50	1.24	.82
Rfc4	KLA  ATP  ATP+KLA	NM_145480	replication factor C (activator 1) 4 (Rfc4), mRNA [NM_145480]	KLA	.39	.38	.36	.37	.31	.44	.35
				ATP	.97	.92	1.27	1.00	.55	.45	.32
				KLA/ATP	.39	.36	.50	.36	.33	.38	.24
Rfc5	KLA  ATP  ATP+KLA	NM_028128	replication factor C (activator 1) 5 (Rfc5), mRNA [NM_028128]	KLA	.67	.65	.67	.61	.50	.52	.41
				ATP	.95	.90	1.04	1.05	.59	.34	.42
				KLA/ATP	.60	.60	.69	.64	.53	.45	.48
Rnaseh1	KLA  ATP  ATP+KLA	NM_011275	ribonuclease H1 (Rnaseh1), mRNA [NM_011275]	KLA	1.40	1.35	1.20	.84	.79	.83	1.08
				ATP	.96	1.03	.92	.79	.53	.67	1.08
				KLA/ATP	1.30	1.41	1.37	1.18	.51	.65	.76
Rnaseh2a	KLA  ATP  ATP+KLA	NM_027187	ribonuclease H2, large subunit (Rnaseh2a), mRNA [NM_027187]	KLA	1.01	1.04	1.10	1.11	.98	.70	.69
				ATP	1.02	1.10	1.03	1.35	1.12	.79	.67
				KLA/ATP	1.05	1.07	1.09	1.27	1.09	.89	.63
Rnaseh2b	KLA  ATP  ATP+KLA	NM_026001	ribonuclease H2, subunit B (Rnaseh2b), mRNA [NM_026001]	KLA	1.52	1.61	1.72	1.73	1.55	1.17	.80
				ATP	.93	.93	1.08	1.10	.89	.85	.56
				KLA/ATP	1.38	1.50	1.84	1.87	1.67	1.65	1.15
Rnaseh2c	KLA  ATP  ATP+KLA	NM_026616	ribonuclease H2, subunit C (Rnaseh2c), mRNA [NM_026616]	KLA	.73	.71	.68	.69	.50	.38	.42
				ATP	.90	.90	1.29	1.36	1.11	.88	.71
				KLA/ATP	.68	.72	1.03	1.02	.98	.72	.50
Rpa1	KLA  ATP  ATP+KLA	NM_026653	replication protein A1 (Rpa1), mRNA [NM_026653]	KLA	.51	.51	.42	.36	.30	.42	.32
				ATP	1.01	1.10	1.09	.92	.66	.38	.43
				KLA/ATP	.54	.49	.44	.41	.32	.30	.27
Rpa2	KLA  ATP  ATP+KLA	D00812	mRNA for 30-kDa subunit of replication protein A, complete cds. [D00812]	KLA	.34	.36	.38	.32	.33	.42	.36
				ATP	1.03	1.00	.91	.81	.43	.55	.27
				KLA/ATP	.39	.34	.39	.42	.35	.44	.27
Rpa2	KLA  ATP  ATP+KLA	NM_011284	replication protein A2 (Rpa2), mRNA [NM_011284]	KLA	.34	.37	.38	.35	.36	.42	.36
				ATP	.98	.93	.87	.81	.47	.53	.26
				KLA/ATP	.36	.34	.40	.42	.36	.47	.24
Rpa3	KLA  ATP  ATP+KLA	NM_026632	replication protein A3 (Rpa3), mRNA [NM_026632]	KLA	.54	.49	.54	.52	.46	.55	.48
				ATP	.89	.88	1.39	1.24	.56	.41	.39
				KLA/ATP	.48	.54	.77	.61	.41	.42	.32
Ssbp1	KLA  ATP  ATP+KLA	NM_028358	single-stranded DNA binding protein 1 (Ssbp1), transcript variant 2, mRNA [NM_028358]	KLA	.85	.82	.84	.89	.78	.95	.97
				ATP	.79	.68	.85	.69	.77	1.24	.85
				KLA/ATP	.72	.71	.95	.72	.86	.94	.66
Ssbp1	KLA  ATP  ATP+KLA	NM_212468	single-stranded DNA binding protein 1 (Ssbp1), transcript variant 1, mRNA [NM_212468]	KLA	.87	.89	.86	.81	.82	.89	.86
				ATP	.87	.84	.89	.78	.78	.77	.72
				KLA/ATP	.83	.79	.82	.71	.78	.75	.63