Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: 2-Oxocarboxylic acid metabolism (mmu01210)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
4933405O 20Rik	KLA  ATP  ATP+KLA	NM_172901	RIKEN cDNA 4933405O20 gene (4933405O20Rik), mRNA [NM_172901]	KLA	.98	.99	1.01	1.07	1.03	1.01	1.03
				ATP	.95	.97	.99	.96	.99	1.01	1.02
				KLA/ATP	.93	1.01	.99	.98	.98	.92	.96
Aadat	KLA  ATP  ATP+KLA	NM_011834	aminoadipate aminotransferase (Aadat), mRNA [NM_011834]	KLA	1.05	1.06	1.04	.98	1.00	1.04	.98
				ATP	.98	.99	1.10	1.03	1.00	1.04	1.03
				KLA/ATP	1.05	1.09	1.07	1.04	.97	1.06	1.05
Aco1	KLA  ATP  ATP+KLA	NM_007386	aconitase 1 (Aco1), mRNA [NM_007386]	KLA	.82	.85	.80	.78	.73	.74	.84
				ATP	1.02	1.07	1.04	.96	.95	.88	.83
				KLA/ATP	.83	.86	.81	.80	.76	.73	.62
Aco2	KLA  ATP  ATP+KLA	AK029122	10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732494K09 product:hypothetical protein, full insert sequence [AK029122]	KLA	1.02	1.02	.99	.98	.97	1.04	.83
				ATP	.98	1.04	1.05	.95	.95	1.02	1.00
				KLA/ATP	.96	.95	1.00	1.04	1.06	1.03	.99
Aco2	KLA  ATP  ATP+KLA	NM_080633	aconitase 2, mitochondrial (Aco2), nuclear gene encoding mitochondrial protein, mRNA [NM_080633]	KLA	.93	.96	.97	.91	.97	.99	1.07
				ATP	1.05	1.04	.98	.92	.90	.83	.99
				KLA/ATP	1.01	1.06	.86	.89	.83	.93	.93
Acy1	KLA  ATP  ATP+KLA	NM_025371	aminoacylase 1 (Acy1), mRNA [NM_025371]	KLA	1.09	1.23	1.15	1.16	1.14	1.11	.71
				ATP	1.00	1.03	.98	1.13	1.30	1.30	1.13
				KLA/ATP	1.22	1.18	.95	1.22	1.08	1.03	.71
Bcat1	KLA  ATP  ATP+KLA	NM_001024468	branched chain aminotransferase 1, cytosolic (Bcat1), transcript variant 1, mRNA [NM_001024468]	KLA	1.04	1.03	.98	1.04	.99	1.02	1.03
				ATP	1.00	1.01	1.02	1.01	1.12	1.25	1.09
				KLA/ATP	.99	1.00	1.04	1.04	1.01	1.08	1.15
Bcat2	KLA  ATP  ATP+KLA	NM_009737	branched chain aminotransferase 2, mitochondrial (Bcat2), nuclear gene encoding mitochondrial protein, mRNA [NM_009737]	KLA	1.06	1.05	1.08	.97	1.08	.96	1.61
				ATP	1.07	1.42	.96	1.55	.87	.66	.96
				KLA/ATP	1.27	1.29	.84	1.36	.81	.76	.92
Cs	KLA  ATP  ATP+KLA	NM_026444	citrate synthase (Cs), nuclear gene encoding mitochondrial protein, mRNA [NM_026444]	KLA	1.09	1.07	1.04	1.05	1.08	1.15	1.14
				ATP	.91	.93	1.02	.90	.90	1.08	1.38
				KLA/ATP	.99	1.04	1.09	.98	.98	.90	1.13
Csl	KLA  ATP  ATP+KLA	NM_027945	citrate synthase like (Csl), mRNA [NM_027945]	KLA	1.41	1.32	1.35	1.51	1.61	1.39	1.58
				ATP	1.17	1.15	.98	1.23	1.18	1.33	2.00
				KLA/ATP	1.32	1.53	1.45	1.59	1.13	1.14	1.77
Got1	KLA  ATP  ATP+KLA	NM_010324	glutamate oxaloacetate transaminase 1, soluble (Got1), mRNA [NM_010324]	KLA	.68	.70	.66	.56	.50	.57	.99
				ATP	1.01	1.24	1.55	1.59	1.47	1.03	1.68
				KLA/ATP	.68	.71	.66	.77	1.13	2.33	1.89
Got2	KLA  ATP  ATP+KLA	NM_010325	glutamate oxaloacetate transaminase 2, mitochondrial (Got2), nuclear gene encoding mitochondrial protein, mRNA [NM_010325]	KLA	.84	.86	.88	.75	.75	.63	.61
				ATP	1.02	1.12	.98	1.15	.98	.67	.86
				KLA/ATP	.92	.89	.75	.89	.68	.70	.77
Gpt	KLA  ATP  ATP+KLA	NM_182805	glutamic pyruvic transaminase, soluble (Gpt), mRNA [NM_182805]	KLA	.82	.81	.80	.82	.78	.83	1.05
				ATP	1.01	1.00	1.07	1.23	1.20	.77	1.01
				KLA/ATP	.85	.86	.93	1.01	1.32	.83	.97
Gpt2	KLA  ATP  ATP+KLA	NM_173866	glutamic pyruvate transaminase (alanine aminotransferase) 2 (Gpt2), mRNA [NM_173866]	KLA	.82	.87	.84	.69	.64	.80	.91
				ATP	.97	1.08	1.06	.95	1.33	2.66	1.89
				KLA/ATP	.81	.83	.67	.70	1.07	2.66	1.63
Idh1	KLA  ATP  ATP+KLA	NM_010497	isocitrate dehydrogenase 1 (NADP+), soluble (Idh1), transcript variant 2, mRNA [NM_010497]	KLA	.71	.74	.69	.70	.54	.45	.63
				ATP	1.22	1.28	1.00	1.28	1.06	.62	.81
				KLA/ATP	.76	.81	.68	.88	.55	.47	.40
Idh2	KLA  ATP  ATP+KLA	NM_173011	isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2), nuclear gene encoding mitochondrial protein, mRNA [NM_173011]	KLA	.83	.83	.88	.94	.66	.31	.38
				ATP	1.04	1.09	1.14	1.48	1.26	.39	.49
				KLA/ATP	.90	.92	1.04	1.10	.82	.41	.20
Idh3a	KLA  ATP  ATP+KLA	NM_029573	isocitrate dehydrogenase 3 (NAD+) alpha (Idh3a), nuclear gene encoding mitochondrial protein, mRNA [NM_029573]	KLA	.99	1.06	.85	.83	.67	.51	.73
				ATP	.95	1.07	1.12	1.22	.93	.46	.52
				KLA/ATP	.92	1.00	.91	1.12	.75	.42	.21
Idh3b	KLA  ATP  ATP+KLA	NM_130884	isocitrate dehydrogenase 3 (NAD+) beta (Idh3b), nuclear gene encoding mitochondrial protein, mRNA [NM_130884]	KLA	.89	.94	.94	.89	.97	1.00	1.12
				ATP	1.01	1.07	.94	1.16	.94	.52	.68
				KLA/ATP	.92	.94	.78	1.05	.78	.73	.58
Idh3g	KLA  ATP  ATP+KLA	NM_008323	isocitrate dehydrogenase 3 (NAD+), gamma (Idh3g), nuclear gene encoding mitochondrial protein, mRNA [NM_008323]	KLA	.74	.69	.66	.68	.61	.55	.63
				ATP	.94	.91	1.06	1.09	.93	.66	.62
				KLA/ATP	.72	.74	.80	.80	.73	.56	.48
Nags	KLA  ATP  ATP+KLA	NM_145829	N-acetylglutamate synthase (Nags), transcript variant 1, mRNA [NM_145829]	KLA	.99	.97	1.02	1.06	1.03	1.03	1.08
				ATP	.95	.98	1.07	1.12	1.17	1.38	1.26
				KLA/ATP	.97	1.05	1.10	1.42	1.31	1.52	1.27
Nags	KLA  ATP  ATP+KLA	NM_178053	N-acetylglutamate synthase (Nags), transcript variant 2, mRNA [NM_178053]	KLA	1.01	.98	1.07	1.10	1.02	1.02	1.06
				ATP	1.07	1.06	1.12	1.00	1.56	2.35	1.57
				KLA/ATP	.98	1.02	1.09	.94	1.32	1.66	1.29