Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Folate biosynthesis (mmu00790)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
Akp3	KLA  ATP  ATP+KLA	NM_007432	alkaline phosphatase 3, intestine, not Mn requiring (Akp3), mRNA [NM_007432]	KLA	.99	1.04	1.02	1.06	1.02	1.04	1.09
				ATP	1.04	1.03	1.06	1.05	.98	1.01	1.05
				KLA/ATP	1.04	1.01	1.00	1.02	1.06	1.07	1.01
Akp5	KLA  ATP  ATP+KLA	NM_007433	alkaline phosphatase 5 (Akp5), mRNA [NM_007433]	KLA	.99	.97	.95	.95	.98	1.01	.96
				ATP	1.01	.94	1.03	.96	.94	1.04	1.05
				KLA/ATP	.92	.94	.97	.96	.94	.94	.90
Alpi	KLA  ATP  ATP+KLA	NM_001081082	alkaline phosphatase, intestinal (Alpi), mRNA [NM_001081082]	KLA	1.03	1.06	.97	.99	1.06	1.04	1.02
				ATP	1.02	1.04	1.00	1.09	1.06	.96	1.01
				KLA/ATP	.99	1.01	1.07	1.02	1.02	.93	.99
Alpl	KLA  ATP  ATP+KLA	NM_007431	alkaline phosphatase, liver/bone/kidney (Alpl), mRNA [NM_007431]	KLA	.98	.95	1.02	1.00	.97	.99	1.08
				ATP	.99	1.06	.96	.99	.96	1.02	1.04
				KLA/ATP	.96	1.05	1.02	.94	1.03	1.03	1.01
Dhfr	KLA  ATP  ATP+KLA	L26316	dihydrofolate reductase (dhfr) mRNA, complete cds. [L26316]	KLA	.63	.69	.61	.62	.53	.57	.45
				ATP	.93	.93	1.10	1.12	.84	.49	.39
				KLA/ATP	.66	.59	.72	.74	.67	.65	.90
Dhfr	KLA  ATP  ATP+KLA	NM_010049	dihydrofolate reductase (Dhfr), mRNA [NM_010049]	KLA	.52	.51	.48	.47	.39	.49	.33
				ATP	.90	.90	1.13	1.05	.76	.40	.28
				KLA/ATP	.46	.48	.58	.59	.59	.57	.68
Fpgs	KLA  ATP  ATP+KLA	NM_010236	folylpolyglutamyl synthetase (Fpgs), nuclear gene encoding mitochondrial protein, mRNA [NM_010236]	KLA	.45	.40	.39	.37	.40	.40	.69
				ATP	.98	.87	1.10	.89	.80	.93	.82
				KLA/ATP	.46	.39	.44	.39	.59	.56	.43
Gch1	KLA  ATP  ATP+KLA	NM_008102	GTP cyclohydrolase 1 (Gch1), mRNA [NM_008102]	KLA	7.78	7.74	8.92	8.50	8.61	6.39	4.13
				ATP	1.00	1.05	1.80	4.55	8.06	5.95	2.30
				KLA/ATP	7.70	8.52	9.93	14.71	14.00	8.42	4.27
Ggh	KLA  ATP  ATP+KLA	NM_010281	gamma-glutamyl hydrolase (Ggh), mRNA [NM_010281]	KLA	1.14	1.07	1.19	1.22	1.12	1.06	1.38
				ATP	1.01	1.01	1.38	1.13	1.08	1.03	.96
				KLA/ATP	1.11	1.16	1.55	1.18	1.04	.99	1.43
Mm.58068	KLA  ATP  ATP+KLA	124487322	Unknown	KLA	1.01	.98	1.02	.99	1.04	1.10	1.07
				ATP	1.05	1.00	1.07	1.00	1.01	1.02	1.08
				KLA/ATP	.97	.94	.95	.94	.99	1.08	1.01
Mocs1	KLA  ATP  ATP+KLA	NM_020042	molybdenum cofactor synthesis 1 (Mocs1), transcript variant 1, mRNA [NM_020042]	KLA	1.79	1.98	2.19	2.29	2.97	3.11	2.73
				ATP	1.04	1.10	1.15	1.46	1.30	1.68	1.29
				KLA/ATP	1.97	2.20	2.03	2.45	1.60	1.88	2.90
Mocs2	KLA  ATP  ATP+KLA	AF091872	molybdopterin-synthase small and large subunit (Mocs2) bicistronic mRNA, complete cds. [AF091872]	KLA	1.48	1.65	2.02	2.31	2.45	2.95	1.68
				ATP	.94	.80	.87	.66	.81	1.86	2.21
				KLA/ATP	1.47	1.31	1.62	1.29	1.85	2.40	3.27
Mocs2	KLA  ATP  ATP+KLA	NM_013826	molybdenum cofactor synthesis 2 (Mocs2), transcript variant 1, mRNA [NM_013826]	KLA	1.45	1.49	1.75	2.08	2.20	2.83	1.69
				ATP	.83	.74	.80	.65	.77	1.68	2.23
				KLA/ATP	1.32	1.23	1.38	1.18	1.67	2.36	2.99
Pts	KLA  ATP  ATP+KLA	NM_011220	6-pyruvoyl-tetrahydropterin synthase (Pts), mRNA [NM_011220]	KLA	1.12	1.20	1.22	1.18	1.22	1.30	1.00
				ATP	.84	.77	1.06	.97	.88	.70	.69
				KLA/ATP	.94	.95	1.32	1.08	1.11	.87	.84
Qdpr	KLA  ATP  ATP+KLA	NM_024236	quinoid dihydropteridine reductase (Qdpr), mRNA [NM_024236]	KLA	.88	.92	.85	.73	.82	.57	.49
				ATP	1.16	1.24	1.00	1.09	1.01	.58	.53
				KLA/ATP	.86	.99	.90	.92	.70	.50	.25
Spr	KLA  ATP  ATP+KLA	NM_011467	sepiapterin reductase (Spr), mRNA [NM_011467]	KLA	.62	.69	.58	.53	.44	.46	.72
				ATP	.95	1.09	.91	1.02	.73	.52	.87
				KLA/ATP	.68	.71	.65	.67	.54	.40	.46