Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Propanoate metabolism (mmu00640)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
Abat	KLA  ATP  ATP+KLA	AK083062	12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530041H11 product:hypothetical protein, full insert sequence. [AK083062]	KLA	1.01	1.09	.97	.99	1.03	1.02	1.06
				ATP	.96	.99	1.00	1.11	1.04	.98	1.06
				KLA/ATP	1.06	1.03	.96	1.06	1.10	1.06	.96
Abat	KLA  ATP  ATP+KLA	NM_172961	4-aminobutyrate aminotransferase (Abat), nuclear gene encoding mitochondrial protein, mRNA [NM_172961]	KLA	1.03	.96	.97	1.00	.92	.97	.96
				ATP	.97	.93	1.07	1.04	.97	.99	.98
				KLA/ATP	1.03	1.01	1.00	.98	.94	.89	.97
Acaca	KLA  ATP  ATP+KLA	NM_133360	acetyl-Coenzyme A carboxylase alpha (Acaca), mRNA [NM_133360]	KLA	.99	.94	.95	.93	.95	1.00	1.00
				ATP	.98	.97	.96	.93	.92	.96	.99
				KLA/ATP	1.01	.96	.99	.92	.93	.94	.91
Acacb	KLA  ATP  ATP+KLA	NM_133904	acetyl-Coenzyme A carboxylase beta (Acacb), mRNA [NM_133904]	KLA	1.01	.93	1.00	.99	.95	1.03	.92
				ATP	.96	1.04	1.05	.98	1.04	1.11	1.05
				KLA/ATP	.90	1.01	1.05	1.03	.97	.96	1.08
Acadm	KLA  ATP  ATP+KLA	NM_007382	acyl-Coenzyme A dehydrogenase, medium chain (Acadm), nuclear gene encoding mitochondrial protein, mRNA [NM_007382]	KLA	.57	.50	.50	.37	.34	.34	.54
				ATP	1.09	1.08	1.16	.92	.67	.43	.51
				KLA/ATP	.55	.56	.57	.46	.41	.36	.29
Acat1	KLA  ATP  ATP+KLA	NM_144784	acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784]	KLA	1.04	.99	.95	.99	.81	.83	.51
				ATP	.89	.88	1.21	.99	.67	.36	.47
				KLA/ATP	.86	.97	1.18	.90	.64	.42	.35
Acat2	KLA  ATP  ATP+KLA	NM_009338	acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338]	KLA	1.14	1.13	1.22	1.29	1.10	.93	.81
				ATP	1.04	1.05	1.16	1.35	1.20	1.53	1.16
				KLA/ATP	1.19	1.19	1.41	1.29	1.13	.92	.71
Acss1	KLA  ATP  ATP+KLA	NM_080575	acyl-CoA synthetase short-chain family member 1 (Acss1), nuclear gene encoding mitochondrial protein, mRNA [NM_080575]	KLA	.45	.41	.45	.62	.70	1.05	.43
				ATP	.95	.89	1.35	.86	.81	.57	.55
				KLA/ATP	.38	.37	.61	.51	1.13	1.17	.38
Acss2	KLA  ATP  ATP+KLA	AK003738	18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110017C11 product:acetyl-Coenzyme A synthetase 1 (AMP forming), full insert sequence. [AK003738]	KLA	1.03	.94	1.02	.97	.93	1.01	1.16
				ATP	1.05	.97	.98	1.03	.95	1.31	1.40
				KLA/ATP	.88	1.02	1.01	.93	.93	1.02	1.12
Acss2	KLA  ATP  ATP+KLA	NM_019811	acyl-CoA synthetase short-chain family member 2 (Acss2), mRNA [NM_019811]	KLA	1.19	1.23	1.40	1.49	1.68	1.67	1.82
				ATP	1.10	1.19	1.13	1.16	1.06	3.14	2.63
				KLA/ATP	1.27	1.35	1.37	1.42	1.47	3.47	2.86
Acss3	KLA  ATP  ATP+KLA	NM_198636	acyl-CoA synthetase short-chain family member 3 (Acss3), mRNA [NM_198636]	KLA	.99	.98	.92	1.01	.99	1.03	.98
				ATP	.98	1.06	1.01	.97	.98	1.04	1.00
				KLA/ATP	.96	.97	1.05	1.01	.91	.98	1.04
Aldh1b1	KLA  ATP  ATP+KLA	NM_028270	aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270]	KLA	7.51	7.83	9.27	11.57	11.10	10.78	4.79
				ATP	.93	.91	.90	.89	.73	2.27	2.30
				KLA/ATP	6.45	7.40	9.33	9.54	8.82	12.15	10.67
Aldh2	KLA  ATP  ATP+KLA	AK163452	adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452]	KLA	.62	.65	.59	.60	.63	.64	.49
				ATP	1.01	.91	1.06	.93	1.18	.93	.41
				KLA/ATP	.70	.68	.70	.84	1.16	.96	.45
Aldh2	KLA  ATP  ATP+KLA	NM_009656	aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656]	KLA	.74	.81	.77	.65	.60	.53	.50
				ATP	.98	1.10	.90	1.17	1.04	.82	.60
				KLA/ATP	.84	.86	.77	.82	.72	.66	.51
Aldh3a2	KLA  ATP  ATP+KLA	NM_007437	aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437]	KLA	.86	.83	.79	.79	.80	.97	1.00
				ATP	.93	.98	.94	.89	.77	.87	1.02
				KLA/ATP	.78	.81	.67	.72	.65	.81	.97
Aldh6a1	KLA  ATP  ATP+KLA	NM_134042	aldehyde dehydrogenase family 6, subfamily A1 (Aldh6a1), nuclear gene encoding mitochondrial protein, mRNA [NM_134042]	KLA	1.02	.97	.98	1.15	1.31	1.39	.67
				ATP	.96	.92	1.21	.87	.64	.54	.55
				KLA/ATP	.82	.97	1.04	.87	.80	.59	.36
Aldh7a1	KLA  ATP  ATP+KLA	NM_138600	aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600]	KLA	.98	1.03	1.08	1.12	1.08	.94	.99
				ATP	1.01	1.03	1.00	1.03	.98	.82	.91
				KLA/ATP	1.15	1.12	1.01	1.02	.90	.89	.83
Aldh9a1	KLA  ATP  ATP+KLA	NM_019993	aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993]	KLA	.64	.64	.67	.48	.42	.24	.33
				ATP	1.07	1.02	.75	.94	.68	.46	.42
				KLA/ATP	.72	.65	.43	.55	.37	.31	.24
Echs1	KLA  ATP  ATP+KLA	NM_053119	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (Echs1), nuclear gene encoding mitochondrial protein, mRNA [NM_053119]	KLA	.57	.55	.52	.54	.60	.82	.90
				ATP	.99	.97	1.07	1.15	.77	.37	.81
				KLA/ATP	.55	.56	.55	.66	.53	.39	.41
Ehhadh	KLA  ATP  ATP+KLA	NM_023737	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (Ehhadh), mRNA [NM_023737]	KLA	.74	.77	.80	.88	.71	.67	.74
				ATP	1.02	1.06	1.04	.90	.70	.84	.83
				KLA/ATP	.79	.81	.80	.65	.59	.79	.55
Hadha	KLA  ATP  ATP+KLA	AK050856	9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert	KLA	.96	.92	.91	.80	.97	.92	.90
				ATP	.72	.64	.63	.71	.91	.93	.93
				KLA/ATP	.79	.72	.68	.73	.87	.90	.88
Hadha	KLA  ATP  ATP+KLA	NM_178878	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878]	KLA	1.10	1.17	1.36	1.16	1.23	1.10	1.00
				ATP	1.16	1.22	1.03	1.40	1.09	.79	1.11
				KLA/ATP	1.33	1.35	1.16	1.41	1.00	.92	1.31
Hibch	KLA  ATP  ATP+KLA	NM_146108	3-hydroxyisobutyryl-Coenzyme A hydrolase (Hibch), mRNA [NM_146108]	KLA	.47	.44	.40	.33	.30	.39	.82
				ATP	.92	.92	1.45	1.12	.69	.61	.91
				KLA/ATP	.42	.41	.56	.40	.34	.45	.55
Ldha	KLA  ATP  ATP+KLA	NM_010699	lactate dehydrogenase A (Ldha), mRNA [NM_010699]	KLA	.89	.80	.84	.93	.96	1.04	1.23
				ATP	1.05	1.04	.96	.87	1.21	1.43	1.11
				KLA/ATP	.93	.87	.87	.93	1.24	1.53	.96
Ldhal6b	KLA  ATP  ATP+KLA	NM_175349	lactate dehydrogenase A-like 6B (Ldhal6b), mRNA [NM_175349]	KLA	.89	.90	.94	.92	1.04	1.11	1.20
				ATP	.99	.91	.90	.88	.90	.88	1.17
				KLA/ATP	.93	.97	.87	.89	.91	1.00	1.20
Ldhb	KLA  ATP  ATP+KLA	NM_008492	lactate dehydrogenase B (Ldhb), mRNA [NM_008492]	KLA	1.00	.97	.96	1.00	.78	.63	.39
				ATP	.84	.89	1.11	1.24	1.01	.67	.47
				KLA/ATP	.94	1.03	1.35	1.92	1.40	.85	.47
Ldhc	KLA  ATP  ATP+KLA	NM_013580	lactate dehydrogenase C (Ldhc), mRNA [NM_013580]	KLA	.98	1.02	1.04	1.02	.97	.95	.99
				ATP	1.02	1.00	.97	.96	1.00	1.00	.95
				KLA/ATP	.96	1.10	1.07	.95	1.03	1.06	1.03
Mcee	KLA  ATP  ATP+KLA	NM_028626	methylmalonyl CoA epimerase (Mcee), mRNA [NM_028626]	KLA	.94	.93	.88	.92	.77	.71	.87
				ATP	.93	.97	1.28	1.51	1.31	.87	.80
				KLA/ATP	.88	.96	1.18	1.37	1.28	.95	.83
Mlycd	KLA  ATP  ATP+KLA	NM_019966	malonyl-CoA decarboxylase (Mlycd), nuclear gene encoding mitochondrial protein, mRNA [NM_019966]	KLA	.77	.70	.74	.89	.75	.81	.66
				ATP	1.01	.91	1.04	.78	.38	.62	.81
				KLA/ATP	.66	.66	.80	.56	.44	.57	.74
Mm.29323 3	KLA  ATP  ATP+KLA	118130035	Unknown	KLA	.98	1.04	.98	1.05	1.07	.97	.95
				ATP	1.02	1.04	1.01	1.02	1.00	1.00	1.00
				KLA/ATP	1.03	1.00	.98	.96	1.10	1.03	.98
Mut	KLA  ATP  ATP+KLA	X51941	gb|Mouse mRNA for methylmalonyl CoA mutase (EC 5.4.99.2) [X51941]	KLA	.57	.56	.51	.56	.55	.63	.69
				ATP	.89	.83	1.05	.71	.41	.29	.88
				KLA/ATP	.52	.51	.62	.40	.29	.23	.38
Pcca	KLA  ATP  ATP+KLA	NM_144844	propionyl-Coenzyme A carboxylase, alpha polypeptide (Pcca), mRNA [NM_144844]	KLA	1.00	1.07	1.11	1.16	1.07	1.01	.68
				ATP	.90	.97	1.10	1.14	.93	.53	.60
				KLA/ATP	.99	1.12	1.16	1.19	.84	.59	.56
Pccb	KLA  ATP  ATP+KLA	NM_025835	propionyl Coenzyme A carboxylase, beta polypeptide (Pccb), mRNA [NM_025835]	KLA	.76	.77	.67	.65	.45	.41	.42
				ATP	.97	1.12	.94	1.15	.90	.51	.37
				KLA/ATP	.83	.82	.80	.88	.65	.46	.28
Sucla2	KLA  ATP  ATP+KLA	AK016060	adult male testis cDNA, RIKEN full-length enriched library, clone:4930547K18 product:unclassifiable, full insert sequence. [AK016060]	KLA	.92	1.07	.96	1.02	.97	.95	1.02
				ATP	1.08	1.02	1.00	1.06	.92	1.01	.94
				KLA/ATP	.94	1.04	1.04	.96	.94	.94	.90
Sucla2	KLA  ATP  ATP+KLA	NM_011506	succinate-Coenzyme A ligase, ADP-forming, beta subunit (Sucla2), nuclear gene encoding mitochondrial protein, mRNA [NM_011506]	KLA	1.10	1.02	1.00	1.06	.87	.81	.86
				ATP	.98	.95	1.30	1.02	.93	.69	.72
				KLA/ATP	.98	1.02	1.35	1.04	1.00	.61	.52
Suclg1	KLA  ATP  ATP+KLA	NM_019879	succinate-CoA ligase, GDP-forming, alpha subunit (Suclg1), mRNA [NM_019879]	KLA	.87	.88	.81	.81	.84	.79	.89
				ATP	1.14	1.06	1.05	1.06	.87	.41	.81
				KLA/ATP	.93	.92	.92	.92	.76	.49	.49
Suclg2	KLA  ATP  ATP+KLA	NM_011507	succinate-Coenzyme A ligase, GDP-forming, beta subunit (Suclg2), mRNA [NM_011507]	KLA	.99	1.07	1.08	.88	.74	.49	.67
				ATP	1.00	1.14	1.15	1.44	.91	.37	.45
				KLA/ATP	1.08	1.08	.94	1.18	.65	.40	.35