Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Ether lipid metabolism (mmu00565)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
Agps	KLA  ATP  ATP+KLA	NM_172666	alkylglycerone phosphate synthase (Agps), mRNA [NM_172666]	KLA	.97	1.04	1.08	.98	.98	1.11	1.31
				ATP	1.03	1.09	1.21	1.08	.76	.98	1.18
				KLA/ATP	1.02	1.09	1.05	.90	.71	.78	1.56
Cept1	KLA  ATP  ATP+KLA	NM_133869	choline/ethanolaminephosphotransferase 1 (Cept1), mRNA [NM_133869]	KLA	3.40	3.07	3.72	5.13	5.83	5.57	2.91
				ATP	1.09	1.05	1.09	.81	1.14	2.16	1.37
				KLA/ATP	3.35	3.19	4.07	2.89	3.10	3.27	4.09
Chpt1	KLA  ATP  ATP+KLA	NM_144807	choline phosphotransferase 1 (Chpt1), mRNA [NM_144807]	KLA	1.16	1.18	1.24	1.15	1.16	1.10	1.23
				ATP	1.01	1.05	1.16	1.09	.99	.97	.98
				KLA/ATP	1.20	1.15	1.13	1.18	1.17	1.33	1.25
D5Wsu178 e	KLA  ATP  ATP+KLA	NM_027652	DNA segment, Chr 5, Wayne State University 178, expressed (D5Wsu178e), mRNA [NM_027652]	KLA	.78	.80	.72	.75	.69	.70	.96
				ATP	1.03	1.09	1.13	1.04	1.22	1.10	.91
				KLA/ATP	.78	.82	.72	.80	.96	.87	.73
Enpp2	KLA  ATP  ATP+KLA	NM_015744	ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2), mRNA [NM_015744]	KLA	1.04	1.06	1.22	1.37	1.63	1.36	1.34
				ATP	1.01	.93	1.01	1.03	1.04	.96	1.11
				KLA/ATP	1.10	1.10	1.17	1.12	1.13	1.19	1.47
Enpp6	KLA  ATP  ATP+KLA	NM_177304	ectonucleotide pyrophosphatase/phosphodiesterase 6 (Enpp6), mRNA [NM_177304]	KLA	.97	.97	1.04	.94	.97	1.02	1.05
				ATP	1.02	.99	.98	.92	.92	.89	1.14
				KLA/ATP	.96	1.03	.92	.92	.88	.98	1.37
Hrasls3	KLA  ATP  ATP+KLA	AK052657	0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630015C01 product:H-REV 107 PROTEIN homolog [Rattus norvegicus], full insert sequence. [AK052657]	KLA	4.07	4.01	2.57	2.26	1.94	1.66	1.10
				ATP	.93	.92	1.00	.96	.95	.99	1.08
				KLA/ATP	3.36	2.63	1.76	1.26	1.41	1.22	1.27
Hrasls3	KLA  ATP  ATP+KLA	NM_139269	HRAS like suppressor 3 (Hrasls3), mRNA [NM_139269]	KLA	11.37	10.85	12.50	16.13	13.98	17.12	6.64
				ATP	.86	.78	.96	.89	.84	.99	1.03
				KLA/ATP	8.90	10.50	15.81	13.10	11.95	11.16	10.19
Lpcat1	KLA  ATP  ATP+KLA	AK155286	NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630214O14 product:Hypothetical phospholipid and glycerol acyltransferase, full insert sequence [AK155286]	KLA	.94	.83	1.02	.83	1.42	.92	.90
				ATP	1.33	1.28	1.03	.82	1.24	.58	.81
				KLA/ATP	1.16	1.13	.83	.60	.71	.53	.50
Lpcat2	KLA  ATP  ATP+KLA	NM_173014	lysophosphatidylcholine acyltransferase 2 (Lpcat2), mRNA [NM_173014]	KLA	1.61	1.75	1.91	2.26	3.20	3.80	3.31
				ATP	1.06	1.08	1.21	1.23	1.11	1.94	1.31
				KLA/ATP	1.61	1.55	1.72	1.65	1.14	1.27	2.62
Mm.16006 7	KLA  ATP  ATP+KLA	124487226	Unknown	KLA	.90	.88	.87	.85	.80	.85	.64
				ATP	.95	.95	1.00	.94	1.00	.91	.67
				KLA/ATP	.89	.86	.93	.82	.85	.84	.63
Mm.25025 6	KLA  ATP  ATP+KLA	168480135	Unknown	KLA	1.63	1.36	1.96	2.39	3.43	2.97	1.72
				ATP	1.10	1.03	1.12	1.16	1.09	1.09	1.12
				KLA/ATP	1.53	1.63	1.74	1.70	1.45	1.62	2.76
Mm.28873	KLA  ATP  ATP+KLA	110431340	Unknown	KLA	.79	.72	.69	.71	.44	.32	.37
				ATP	.89	.88	1.17	.98	1.11	.98	.73
				KLA/ATP	.67	.72	.87	.74	.75	.53	.30
Mm.33050 7	KLA  ATP  ATP+KLA	67906182	Unknown	KLA	.94	.98	.99	1.03	1.05	1.07	.98
				ATP	.95	1.02	.97	.98	.99	1.05	1.02
				KLA/ATP	1.02	1.05	1.01	1.03	.99	.98	.97
Mm.33438	KLA  ATP  ATP+KLA	46402174	Unknown	KLA	1.14	1.18	1.15	.97	.93	.89	.84
				ATP	1.02	1.20	2.15	1.34	.98	.89	.86
				KLA/ATP	1.23	1.19	.91	1.16	.78	.90	.86
Mm.71913	KLA  ATP  ATP+KLA	118130231	Unknown	KLA	.93	1.00	1.06	.97	.95	.98	1.04
				ATP	1.00	.98	1.08	1.02	.92	.90	.99
				KLA/ATP	.99	1.01	1.00	.99	.99	.99	1.01
Pafah1b1	KLA  ATP  ATP+KLA	AK147229	cDNA, RIKEN full-length enriched library, clone:M421028C14 product:platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit, full insert sequence [AK147229]	KLA	.96	.98	.98	1.06	1.15	1.11	1.14
				ATP	1.37	1.70	1.99	1.78	1.62	1.20	1.11
				KLA/ATP	1.44	1.62	1.71	1.45	1.48	1.12	1.21
Pafah1b1	KLA  ATP  ATP+KLA	NM_013625	platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit (Pafah1b1), mRNA [NM_013625]	KLA	.91	.87	.93	.99	1.14	1.21	1.00
				ATP	1.00	1.18	1.06	.73	.96	.65	.40
				KLA/ATP	.82	.80	.87	.71	1.10	.90	.41
Pafah1b2	KLA  ATP  ATP+KLA	NM_008775	platelet-activating factor acetylhydrolase, isoform 1b, alpha2 subunit (Pafah1b2), mRNA [NM_008775]	KLA	1.71	1.86	1.93	1.95	2.18	1.98	1.74
				ATP	1.10	1.18	1.04	1.04	1.16	1.73	1.68
				KLA/ATP	1.82	1.83	1.66	1.81	1.60	1.70	1.90
Pafah1b3	KLA  ATP  ATP+KLA	NM_008776	platelet-activating factor acetylhydrolase, isoform 1b, alpha1 subunit (Pafah1b3), mRNA [NM_008776]	KLA	.87	.90	.84	.76	.75	.62	.71
				ATP	1.05	1.14	1.00	1.24	.98	.69	1.00
				KLA/ATP	.91	.91	.80	1.02	.83	.64	.83
Pafah2	KLA  ATP  ATP+KLA	NM_133880	platelet-activating factor acetylhydrolase 2 (Pafah2), mRNA [NM_133880]	KLA	.66	.65	.67	.62	.59	.62	.81
				ATP	1.07	.90	.68	.48	.56	.91	.78
				KLA/ATP	.75	.59	.52	.39	.44	.46	.50
Pla2g10	KLA  ATP  ATP+KLA	NM_011987	phospholipase A2, group X (Pla2g10), mRNA [NM_011987]	KLA	.99	1.11	1.02	.99	1.00	1.01	1.02
				ATP	1.02	.97	1.01	1.03	1.00	1.02	1.04
				KLA/ATP	1.04	.96	.95	1.04	1.06	1.05	1.01
Pla2g12a	KLA  ATP  ATP+KLA	NM_023196	phospholipase A2, group XIIA (Pla2g12a), transcript variant 1, mRNA [NM_023196]	KLA	1.03	1.06	.97	1.00	.78	.75	.92
				ATP	.91	.99	1.29	1.30	1.20	1.48	1.71
				KLA/ATP	.92	.99	1.19	1.16	1.06	1.12	1.36
Pla2g12a	KLA  ATP  ATP+KLA	NM_183423	phospholipase A2, group XIIA (Pla2g12a), transcript variant 2, mRNA [NM_183423]	KLA	.90	1.00	.87	.95	.76	.68	.88
				ATP	.96	.94	1.26	1.24	1.19	1.47	1.88
				KLA/ATP	.89	.90	1.08	1.07	1.06	1.02	1.59
Pla2g12b	KLA  ATP  ATP+KLA	NM_023530	phospholipase A2, group XIIB (Pla2g12b), mRNA [NM_023530]	KLA	.98	.95	1.05	.99	1.03	.99	.94
				ATP	1.02	1.04	1.07	1.05	.92	1.04	1.00
				KLA/ATP	.98	.92	1.10	1.11	1.09	1.03	1.04
Pla2g1b	KLA  ATP  ATP+KLA	NM_011107	phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107]	KLA	1.00	1.01	1.01	1.11	1.00	1.28	1.00
				ATP	.98	1.03	1.09	1.03	1.01	1.02	1.04
				KLA/ATP	.93	.94	1.01	1.00	.94	1.09	1.07
Pla2g2a	KLA  ATP  ATP+KLA	NM_001082531	phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a), mRNA [NM_001082531]	KLA	1.08	.99	1.00	1.06	.98	1.01	.94
				ATP	1.07	.98	1.04	1.06	.90	.98	.98
				KLA/ATP	.98	1.03	1.00	1.04	.94	.97	.96
Pla2g2c	KLA  ATP  ATP+KLA	NM_008868	phospholipase A2, group IIC (Pla2g2c), mRNA [NM_008868]	KLA	.98	.99	1.05	.98	1.01	1.00	1.04
				ATP	1.08	1.06	1.09	.93	.92	.92	1.00
				KLA/ATP	1.03	1.04	1.02	1.04	.98	1.01	1.02
Pla2g2d	KLA  ATP  ATP+KLA	NM_011109	phospholipase A2, group IID (Pla2g2d), mRNA [NM_011109]	KLA	1.02	1.02	.99	.99	1.00	1.01	1.00
				ATP	.95	1.11	1.10	1.11	.98	.99	1.12
				KLA/ATP	1.02	1.00	1.19	1.11	1.00	.96	1.01
Pla2g2e	KLA  ATP  ATP+KLA	NM_012044	phospholipase A2, group IIE (Pla2g2e), mRNA [NM_012044]	KLA	.78	.75	.74	.72	.62	.69	1.40
				ATP	1.06	1.00	.92	1.04	.83	.76	3.74
				KLA/ATP	.78	.80	.69	.74	.70	.74	2.24
Pla2g2f	KLA  ATP  ATP+KLA	NM_012045	phospholipase A2, group IIF (Pla2g2f), mRNA [NM_012045]	KLA	1.02	.99	1.03	1.01	1.00	.95	.99
				ATP	1.01	1.06	1.11	.97	1.09	1.11	.99
				KLA/ATP	1.10	1.05	1.04	.95	1.04	1.01	.96
Pla2g3	KLA  ATP  ATP+KLA	NM_172791	phospholipase A2, group III (Pla2g3), mRNA [NM_172791]	KLA	1.04	1.05	1.02	1.01	1.04	1.11	1.00
				ATP	.96	.97	1.10	.91	.99	.97	1.08
				KLA/ATP	1.03	1.11	1.10	.98	.95	.98	1.07
Pla2g4a	KLA  ATP  ATP+KLA	NM_008869	phospholipase A2, group IVA (cytosolic, calcium-dependent) (Pla2g4a), mRNA [NM_008869]	KLA	3.93	4.49	4.86	6.40	6.44	3.10	1.68
				ATP	1.13	1.36	1.27	1.30	1.02	5.37	1.47
				KLA/ATP	3.64	4.45	4.76	7.11	2.96	4.08	2.60
Pla2g4b	KLA  ATP  ATP+KLA	NM_145378	phospholipase A2, group IVB (cytosolic) (Pla2g4b), mRNA [NM_145378]	KLA	1.09	1.18	.95	1.01	.97	.97	.77
				ATP	1.05	1.14	1.28	.94	.88	1.18	.70
				KLA/ATP	1.23	1.43	1.21	1.02	1.15	1.16	.78
Pla2g4c	KLA  ATP  ATP+KLA	AK145339	1 cell embryo 1 cell cDNA, RIKEN full-length enriched library, clone:I0C0013F18 product:weakly similar to Cytosolic phospholipase A2 gamma [Homo sapiens], full insert sequence [AK145339]	KLA	1.09	1.21	1.33	1.17	1.26	1.30	1.05
				ATP	.97	1.06	1.00	.98	.98	.98	1.05
				KLA/ATP	1.19	1.16	1.18	1.13	1.04	1.02	1.06
Pla2g4c	KLA  ATP  ATP+KLA	NM_001004762	phospholipase A2, group IVC (cytosolic, calcium-independent) (Pla2g4c), mRNA [NM_001004762]	KLA	.93	1.00	.94	.93	.94	.94	.96
				ATP	.98	.96	1.13	.97	.99	.89	.96
				KLA/ATP	1.01	1.01	1.07	1.01	.94	1.01	.92
Pla2g4e	KLA  ATP  ATP+KLA	AK049063	0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230096D22 product:hypothetical Lysophospholipase catalytic domain containing protein, full insert sequence. [AK049063]	KLA	1.03	1.09	1.01	1.01	1.06	.94	1.05
				ATP	1.03	1.00	1.06	1.01	.96	1.05	1.05
				KLA/ATP	.98	1.00	1.01	.98	1.03	.95	1.01
Pla2g4e	KLA  ATP  ATP+KLA	NM_177845	phospholipase A2, group IVE (Pla2g4e), mRNA [NM_177845]	KLA	.97	.95	1.01	.97	1.02	1.03	1.05
				ATP	.98	.99	1.00	1.10	.98	1.00	1.02
				KLA/ATP	1.05	.93	.96	1.03	1.08	1.05	.99
Pla2g4f	KLA  ATP  ATP+KLA	NM_001024145	phospholipase A2, group IVF (Pla2g4f), mRNA [NM_001024145]	KLA	1.08	.99	1.04	1.02	1.04	.98	1.01
				ATP	.99	1.04	.99	1.03	1.12	1.01	1.25
				KLA/ATP	.97	1.04	1.10	1.06	1.04	1.03	1.03
Pla2g5	KLA  ATP  ATP+KLA	NM_011110	phospholipase A2, group V (Pla2g5), transcript variant 2, mRNA [NM_011110]	KLA	.65	.62	.56	.53	.62	1.60	3.01
				ATP	.90	.82	.88	1.69	1.82	1.26	6.32
				KLA/ATP	.63	.59	.65	.63	.91	1.56	5.59
Pla2g6	KLA  ATP  ATP+KLA	NM_016915	phospholipase A2, group VI (Pla2g6), mRNA [NM_016915]	KLA	.60	.59	.56	.60	.94	1.31	1.59
				ATP	1.10	1.14	.95	1.05	1.06	1.13	1.14
				KLA/ATP	.63	.56	.54	.56	.71	.97	1.55
Pla2g7	KLA  ATP  ATP+KLA	NM_013737	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (Pla2g7), mRNA [NM_013737]	KLA	1.26	1.32	1.43	1.47	1.87	2.52	4.77
				ATP	1.07	1.11	.94	1.24	1.14	3.60	7.17
				KLA/ATP	1.38	1.44	1.13	1.63	1.40	4.09	10.65
Plb1	KLA  ATP  ATP+KLA	AK015993	adult male testis cDNA, RIKEN full-length enriched library, clone:4930539A06 product:weakly similar to PHOSPHOLIPASE B [Rattus norvegicus], full insert sequence. [AK015993]	KLA	.99	.99	1.05	1.02	1.03	1.07	1.02
				ATP	1.04	1.03	1.07	1.06	1.09	1.01	1.02
				KLA/ATP	1.07	1.00	.96	1.09	1.05	1.08	1.01
Plb1	KLA  ATP  ATP+KLA	AK087596	2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230021C09 product:hypothetical protein, full insert sequence. [AK087596]	KLA	.93	.99	.99	1.07	.98	1.00	.98
				ATP	1.08	1.00	.97	1.07	1.04	1.09	.96
				KLA/ATP	1.06	.96	1.00	.98	1.04	1.06	.98
Plb1	KLA  ATP  ATP+KLA	NM_001081407	phospholipase B1 (Plb1), mRNA [NM_001081407]	KLA	1.05	1.09	1.05	1.04	1.05	1.03	.85
				ATP	.96	1.03	1.02	.95	1.06	1.01	.92
				KLA/ATP	1.00	1.00	1.09	1.00	.97	.99	.86
Pld1	KLA  ATP  ATP+KLA	NM_008875	phospholipase D1 (Pld1), mRNA [NM_008875]	KLA	.71	.73	.67	.73	.88	.96	1.25
				ATP	.99	.88	.73	.68	.45	1.23	1.12
				KLA/ATP	.70	.67	.58	.59	.48	.91	1.48
Pld2	KLA  ATP  ATP+KLA	NM_008876	phospholipase D2 (Pld2), mRNA [NM_008876]	KLA	.51	.54	.48	.51	.73	.79	1.02
				ATP	1.06	1.10	.88	1.03	1.04	1.29	1.00
				KLA/ATP	.63	.52	.40	.57	.65	1.03	1.35
Pld3	KLA  ATP  ATP+KLA	NM_011116	phospholipase D family, member 3 (Pld3), mRNA [NM_011116]	KLA	.81	.84	.90	.75	.75	.70	.82
				ATP	1.06	1.14	.81	1.15	1.12	.97	1.32
				KLA/ATP	.94	.92	.73	1.01	.94	1.05	1.20
Pld4	KLA  ATP  ATP+KLA	NM_178911	phospholipase D family, member 4 (Pld4), mRNA [NM_178911]	KLA	.66	.73	.82	.67	.90	1.14	1.94
				ATP	1.08	1.24	.87	1.26	.86	.50	.75
				KLA/ATP	.84	.83	.51	.83	.56	.61	1.00
Ppap2a	KLA  ATP  ATP+KLA	NM_008903	phosphatidic acid phosphatase 2a (Ppap2a), transcript variant 2, mRNA [NM_008903]	KLA	2.62	2.86	4.01	5.61	7.84	10.88	16.35
				ATP	1.01	1.02	1.09	1.28	1.27	2.38	1.44
				KLA/ATP	2.78	2.78	2.99	3.43	2.85	3.59	6.59
Ppap2b	KLA  ATP  ATP+KLA	NM_080555	phosphatidic acid phosphatase type 2B (Ppap2b), mRNA [NM_080555]	KLA	2.73	2.72	2.65	2.39	1.07	1.48	3.26
				ATP	.99	.97	1.60	2.76	18.64	27.23	9.19
				KLA/ATP	2.69	2.80	4.36	4.20	14.33	15.32	17.91
Ppap2c	KLA  ATP  ATP+KLA	NM_015817	phosphatidic acid phosphatase type 2c (Ppap2c), mRNA [NM_015817]	KLA	.94	.88	.91	.79	.65	.46	.51
				ATP	1.01	1.03	1.00	1.12	1.24	.90	.83
				KLA/ATP	.95	.93	.87	.95	.79	.63	.43