Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Selenocompound metabolism (mmu00450)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
BB135800	KLA  ATP  ATP+KLA	BB135800	gb|BB135800 RIKEN full-length enriched, adult male bone Mus musculus cDNA clone 9830130K22 3. [BB135800]	KLA	1.36	1.43	1.30	1.43	1.57	2.06	1.47
				ATP	1.10	1.08	.99	1.05	1.12	1.64	1.99
				KLA/ATP	1.45	1.58	1.65	1.46	1.76	2.32	6.28
Ccbl1	KLA  ATP  ATP+KLA	NM_172404	cysteine conjugate-beta lyase 1 (Ccbl1), mRNA [NM_172404]	KLA	.68	.64	.61	.59	.58	.75	.89
				ATP	1.02	.96	.89	.80	.63	.48	.97
				KLA/ATP	.71	.68	.61	.64	.53	.50	.60
Ccbl2	KLA  ATP  ATP+KLA	NM_173763	cysteine conjugate-beta lyase 2 (Ccbl2), mRNA [NM_173763]	KLA	2.01	2.14	2.03	1.98	1.40	.85	.65
				ATP	.96	.91	1.14	.95	.81	1.04	.68
				KLA/ATP	2.05	2.10	2.27	1.79	1.55	1.00	.57
Cth	KLA  ATP  ATP+KLA	NM_145953	cystathionase (cystathionine gamma-lyase) (Cth), mRNA [NM_145953]	KLA	1.95	1.88	2.04	1.99	1.70	1.19	1.05
				ATP	1.05	1.03	1.17	1.26	1.76	2.05	1.00
				KLA/ATP	1.79	2.03	2.06	1.83	1.66	1.53	.99
Inmt	KLA  ATP  ATP+KLA	NM_009349	indolethylamine N-methyltransferase (Inmt), mRNA [NM_009349]	KLA	1.93	2.09	2.34	2.04	2.49	1.90	1.81
				ATP	.97	1.13	.96	1.21	1.04	1.02	1.40
				KLA/ATP	2.00	2.00	1.37	1.91	1.41	1.31	1.62
Mars	KLA  ATP  ATP+KLA	NM_001003913	methionine-tRNA synthetase (Mars), mRNA [NM_001003913]	KLA	.82	.84	.78	.65	.59	.79	1.13
				ATP	.92	.99	1.04	1.19	1.17	.87	1.42
				KLA/ATP	.86	.83	.85	.85	.74	.76	1.06
Mars2	KLA  ATP  ATP+KLA	NM_175439	methionine-tRNA synthetase 2 (mitochondrial) (Mars2), nuclear gene encoding mitochondrial protein, mRNA [NM_175439]	KLA	.55	.60	.56	.53	.52	.61	.83
				ATP	.91	.85	.65	.48	.79	.71	1.01
				KLA/ATP	.55	.56	.53	.45	.47	.62	.61
Mm.28173	KLA  ATP  ATP+KLA	51491851	Unknown	KLA	.67	.68	.50	.52	.39	.62	.93
				ATP	.89	.83	1.21	.91	1.09	.95	1.27
				KLA/ATP	.61	.61	.75	.54	.63	.63	.88
Mtr	KLA  ATP  ATP+KLA	AK037599	16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130029B16 product:5-methyltetrahydrofolate-homocysteine methyltransferase, full insert sequence. [AK037599]	KLA	.89	.92	.81	.83	.73	.76	.98
				ATP	.98	1.11	.85	.93	.68	.72	1.12
				KLA/ATP	.92	.93	.71	.85	.66	.68	.77
Mtr	KLA  ATP  ATP+KLA	NM_001081128	5-methyltetrahydrofolate-homocysteine methyltransferase (Mtr), mRNA [NM_001081128]	KLA	.93	.91	.89	.77	.64	.58	.99
				ATP	1.12	1.11	1.05	.87	.71	.69	1.59
				KLA/ATP	1.02	.95	.96	.78	.54	.55	.92
Papss1	KLA  ATP  ATP+KLA	NM_011863	3-phosphoadenosine 5-phosphosulfate synthase 1 (Papss1), mRNA [NM_011863]	KLA	.86	.95	.84	.89	.77	.70	.81
				ATP	.99	1.02	1.06	1.10	.74	.64	.75
				KLA/ATP	.93	.89	.86	.93	.68	.56	.69
Papss2	KLA  ATP  ATP+KLA	AK029185	0 day neonate head cDNA, RIKEN full-length enriched library, clone:4831410G12 product:3-phosphoadenosine 5-phosphosulfate synthase 2, full insert sequence. [AK029185]	KLA	1.04	1.07	.97	.95	1.08	1.07	.94
				ATP	.96	1.01	1.00	1.02	.96	1.01	.97
				KLA/ATP	.99	1.01	1.02	1.11	1.01	.98	1.02
Papss2	KLA  ATP  ATP+KLA	NM_011864	3-phosphoadenosine 5-phosphosulfate synthase 2 (Papss2), mRNA [NM_011864]	KLA	1.72	1.84	1.85	1.50	1.56	1.01	1.14
				ATP	1.07	1.14	1.07	1.00	1.19	1.75	1.07
				KLA/ATP	1.64	1.73	1.57	1.58	1.46	1.54	1.10
Pstk	KLA  ATP  ATP+KLA	AK017332	6 days neonate head cDNA, RIKEN full-length enriched library, clone:5430423O14 product:unclassifiable, full insert sequence. [AK017332]	KLA	.57	.54	.54	.59	.71	.59	.77
				ATP	.68	.50	.48	.40	.52	.63	.84
				KLA/ATP	.45	.47	.50	.49	.56	.53	.50
Pstk	KLA  ATP  ATP+KLA	NM_001039534	phosphoseryl-tRNA kinase (Pstk), mRNA [NM_001039534]	KLA	.46	.46	.41	.45	.47	.54	.88
				ATP	.93	.81	1.00	.82	.49	.55	.77
				KLA/ATP	.43	.42	.48	.47	.41	.45	.36
Scly	KLA  ATP  ATP+KLA	NM_016717	selenocysteine lyase (Scly), mRNA [NM_016717]	KLA	1.01	.98	1.02	1.06	1.13	1.12	1.31
				ATP	1.13	1.20	.97	1.14	.76	.60	1.20
				KLA/ATP	1.18	1.16	.99	1.21	.76	.64	1.49
Sephs1	KLA  ATP  ATP+KLA	NM_175400	selenophosphate synthetase 1 (Sephs1), mRNA [NM_175400]	KLA	.92	.97	.99	.96	.87	.77	.73
				ATP	1.04	1.08	.95	.89	.70	.70	.55
				KLA/ATP	.91	1.05	.85	.92	.75	.73	.46
Sephs2	KLA  ATP  ATP+KLA	NM_009266	selenophosphate synthetase 2 (Sephs2), mRNA [NM_009266]	KLA	.74	.81	.66	.57	.59	.85	1.22
				ATP	1.00	1.11	.95	.90	.80	.65	.67
				KLA/ATP	.73	.81	.61	.72	.58	.61	.65
Sepsecs	KLA  ATP  ATP+KLA	AK088165	2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430005G07 product:unclassifiable, full insert sequence. [AK088165]	KLA	.92	.97	1.01	.94	.96	.93	.95
				ATP	1.01	1.04	1.04	1.15	1.01	1.03	.94
				KLA/ATP	1.02	1.01	.92	1.04	.89	.91	.77
Sepsecs	KLA  ATP  ATP+KLA	NM_172490	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase (Sepsecs), mRNA [NM_172490]	KLA	1.29	1.33	1.42	1.25	1.15	1.02	1.29
				ATP	1.09	1.14	.97	.88	1.09	1.22	1.52
				KLA/ATP	1.38	1.53	1.26	1.05	.80	.97	1.41
Txnrd1	KLA  ATP  ATP+KLA	NM_001042523	thioredoxin reductase 1 (Txnrd1), transcript variant 1, mRNA [NM_001042523]	KLA	1.52	1.48	1.01	.65	.59	.68	.96
				ATP	.97	.98	.74	.89	3.11	6.97	1.02
				KLA/ATP	1.41	1.37	.78	.72	1.65	4.48	1.36
Txnrd2	KLA  ATP  ATP+KLA	AK008004	adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010001F03 product:ADULT MALE SMALL INTESTINE CDNA, RIKEN FULL-LENGTH ENRICHED LIBRARY, CLONE:2010001F03, FULL INSERT SEQUENCE, full insert sequence. [AK008004]	KLA	1.35	1.23	1.26	1.32	1.07	1.01	.94
				ATP	.91	.87	1.52	1.79	1.51	1.21	1.00
				KLA/ATP	1.15	1.41	2.12	1.88	1.76	1.23	.91
Txnrd2	KLA  ATP  ATP+KLA	NM_013711	thioredoxin reductase 2 (Txnrd2), nuclear gene encoding mitochondrial protein, mRNA [NM_013711]	KLA	.84	.83	.83	.78	.75	.64	.92
				ATP	1.12	1.20	1.08	1.25	.87	.44	.88
				KLA/ATP	.95	.90	.82	.93	.65	.43	.50
Txnrd3	KLA  ATP  ATP+KLA	NM_153162	thioredoxin reductase 3 (Txnrd3), mRNA [NM_153162]	KLA	.99	.95	.69	.52	.49	.61	1.04
				ATP	.95	1.01	.95	.86	1.80	1.87	1.10
				KLA/ATP	.99	.89	.72	.72	1.20	1.46	.82