Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Tryptophan metabolism (mmu00380)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
4930438A 08Rik	KLA  ATP  ATP+KLA	XM_001477470	gb|PREDICTED: Mus musculus RIKEN cDNA 4930438A08 gene (4930438A08Rik), mRNA [XM_001477470]	KLA	1.78	1.45	1.69	1.62	1.69	1.48	1.31
				ATP	1.07	1.04	1.24	1.13	1.13	1.61	1.67
				KLA/ATP	1.83	1.46	1.58	1.30	1.43	1.36	1.95
Aadat	KLA  ATP  ATP+KLA	NM_011834	aminoadipate aminotransferase (Aadat), mRNA [NM_011834]	KLA	1.05	1.06	1.04	.98	1.00	1.04	.98
				ATP	.98	.99	1.10	1.03	1.00	1.04	1.03
				KLA/ATP	1.05	1.09	1.07	1.04	.97	1.06	1.05
Aanat	KLA  ATP  ATP+KLA	NM_009591	arylalkylamine N-acetyltransferase (Aanat), mRNA [NM_009591]	KLA	1.04	1.01	1.17	1.06	.96	1.09	.99
				ATP	.99	1.02	1.01	.99	1.01	.92	.99
				KLA/ATP	1.01	1.06	1.01	1.04	.99	.99	1.02
Abp1	KLA  ATP  ATP+KLA	NM_029638	amiloride binding protein 1 (amine oxidase, copper-containing) (Abp1), mRNA [NM_029638]	KLA	1.18	1.09	.99	1.08	1.08	.96	1.03
				ATP	1.01	1.02	1.01	.97	1.00	1.00	1.05
				KLA/ATP	1.14	1.10	1.12	1.02	.99	1.04	1.14
Acat1	KLA  ATP  ATP+KLA	NM_144784	acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784]	KLA	1.04	.99	.95	.99	.81	.83	.51
				ATP	.89	.88	1.21	.99	.67	.36	.47
				KLA/ATP	.86	.97	1.18	.90	.64	.42	.35
Acat2	KLA  ATP  ATP+KLA	NM_009338	acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338]	KLA	1.14	1.13	1.22	1.29	1.10	.93	.81
				ATP	1.04	1.05	1.16	1.35	1.20	1.53	1.16
				KLA/ATP	1.19	1.19	1.41	1.29	1.13	.92	.71
Acmsd	KLA  ATP  ATP+KLA	NM_001033041	amino carboxymuconate semialdehyde decarboxylase (Acmsd), mRNA [NM_001033041]	KLA	1.03	1.05	.97	1.03	1.06	.95	.88
				ATP	.93	.99	1.03	1.00	.95	1.04	1.00
				KLA/ATP	.97	.89	1.07	1.03	.95	.91	.95
Afmid	KLA  ATP  ATP+KLA	NM_027827	arylformamidase (Afmid), mRNA [NM_027827]	KLA	.85	.95	.89	.82	1.00	1.22	1.18
				ATP	1.06	1.11	1.05	1.16	1.11	.95	.69
				KLA/ATP	.96	1.09	.95	1.06	1.00	.99	.91
Aldh1b1	KLA  ATP  ATP+KLA	NM_028270	aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270]	KLA	7.51	7.83	9.27	11.57	11.10	10.78	4.79
				ATP	.93	.91	.90	.89	.73	2.27	2.30
				KLA/ATP	6.45	7.40	9.33	9.54	8.82	12.15	10.67
Aldh2	KLA  ATP  ATP+KLA	AK163452	adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452]	KLA	.62	.65	.59	.60	.63	.64	.49
				ATP	1.01	.91	1.06	.93	1.18	.93	.41
				KLA/ATP	.70	.68	.70	.84	1.16	.96	.45
Aldh2	KLA  ATP  ATP+KLA	NM_009656	aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656]	KLA	.74	.81	.77	.65	.60	.53	.50
				ATP	.98	1.10	.90	1.17	1.04	.82	.60
				KLA/ATP	.84	.86	.77	.82	.72	.66	.51
Aldh3a2	KLA  ATP  ATP+KLA	NM_007437	aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437]	KLA	.86	.83	.79	.79	.80	.97	1.00
				ATP	.93	.98	.94	.89	.77	.87	1.02
				KLA/ATP	.78	.81	.67	.72	.65	.81	.97
Aldh7a1	KLA  ATP  ATP+KLA	NM_138600	aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600]	KLA	.98	1.03	1.08	1.12	1.08	.94	.99
				ATP	1.01	1.03	1.00	1.03	.98	.82	.91
				KLA/ATP	1.15	1.12	1.01	1.02	.90	.89	.83
Aldh9a1	KLA  ATP  ATP+KLA	NM_019993	aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993]	KLA	.64	.64	.67	.48	.42	.24	.33
				ATP	1.07	1.02	.75	.94	.68	.46	.42
				KLA/ATP	.72	.65	.43	.55	.37	.31	.24
Aox1	KLA  ATP  ATP+KLA	NM_009676	aldehyde oxidase 1 (Aox1), mRNA [NM_009676]	KLA	.87	.83	.82	.82	.71	.98	1.65
				ATP	1.01	1.02	1.05	.84	.72	.86	.80
				KLA/ATP	.82	.84	.90	.73	.72	.82	1.06
Aox3	KLA  ATP  ATP+KLA	NM_023617	aldehyde oxidase 3 (Aox3), mRNA [NM_023617]	KLA	.95	1.02	1.01	1.00	.99	1.01	1.04
				ATP	1.04	1.03	1.01	.94	1.03	.92	.96
				KLA/ATP	1.09	1.11	1.00	.97	.95	1.01	.94
Aox4	KLA  ATP  ATP+KLA	NM_023631	aldehyde oxidase 4 (Aox4), mRNA [NM_023631]	KLA	.95	.97	.98	1.00	.98	.91	1.06
				ATP	.93	.99	.95	.99	.94	.95	1.00
				KLA/ATP	1.05	1.00	.94	.98	.89	1.00	.93
Cat	KLA  ATP  ATP+KLA	NM_009804	catalase (Cat), mRNA [NM_009804]	KLA	.63	.67	.67	.45	.36	.21	.43
				ATP	1.10	1.25	.91	1.01	.78	1.28	.84
				KLA/ATP	.75	.69	.43	.59	.35	.72	.87
Ccbl1	KLA  ATP  ATP+KLA	NM_172404	cysteine conjugate-beta lyase 1 (Ccbl1), mRNA [NM_172404]	KLA	.68	.64	.61	.59	.58	.75	.89
				ATP	1.02	.96	.89	.80	.63	.48	.97
				KLA/ATP	.71	.68	.61	.64	.53	.50	.60
Ccbl2	KLA  ATP  ATP+KLA	NM_173763	cysteine conjugate-beta lyase 2 (Ccbl2), mRNA [NM_173763]	KLA	2.01	2.14	2.03	1.98	1.40	.85	.65
				ATP	.96	.91	1.14	.95	.81	1.04	.68
				KLA/ATP	2.05	2.10	2.27	1.79	1.55	1.00	.57
Cyp1a1	KLA  ATP  ATP+KLA	NM_009992	cytochrome P450, family 1, subfamily a, polypeptide 1 (Cyp1a1), mRNA [NM_009992]	KLA	1.07	.99	1.02	1.01	1.00	1.00	1.11
				ATP	.99	1.02	1.01	.95	.96	.94	1.09
				KLA/ATP	1.01	1.03	.98	.96	.96	.95	1.51
Cyp1a2	KLA  ATP  ATP+KLA	NM_009993	cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2), mRNA [NM_009993]	KLA	1.01	.99	.98	1.02	.97	.97	1.00
				ATP	1.01	.98	1.03	1.01	1.04	1.02	1.04
				KLA/ATP	.99	1.00	1.05	1.03	.98	.97	.99
Cyp1b1	KLA  ATP  ATP+KLA	AK016699	adult male testis cDNA, RIKEN full-length enriched library, clone:4933406K16 product:cytochrome P450, 1b1, benz[a]anthracene inducible, full insert sequence. [AK016699]	KLA	1.00	1.03	1.00	1.02	1.02	.97	1.03
				ATP	1.00	1.04	1.03	1.13	1.04	1.05	1.02
				KLA/ATP	1.06	1.03	.96	1.05	1.07	1.12	1.09
Cyp1b1	KLA  ATP  ATP+KLA	NM_009994	cytochrome P450, family 1, subfamily b, polypeptide 1 (Cyp1b1), mRNA [NM_009994]	KLA	1.02	.99	1.04	1.05	.98	1.00	1.07
				ATP	1.05	1.01	1.05	1.19	1.09	2.31	5.32
				KLA/ATP	.99	1.02	1.05	1.06	1.14	1.39	3.15
Ddc	KLA  ATP  ATP+KLA	NM_016672	dopa decarboxylase (Ddc), mRNA [NM_016672]	KLA	1.27	1.28	1.34	1.33	1.34	1.21	1.05
				ATP	1.02	.99	1.05	.98	1.02	1.02	1.14
				KLA/ATP	1.24	1.22	1.28	1.25	1.12	1.20	1.35
Echs1	KLA  ATP  ATP+KLA	NM_053119	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (Echs1), nuclear gene encoding mitochondrial protein, mRNA [NM_053119]	KLA	.57	.55	.52	.54	.60	.82	.90
				ATP	.99	.97	1.07	1.15	.77	.37	.81
				KLA/ATP	.55	.56	.55	.66	.53	.39	.41
Ehhadh	KLA  ATP  ATP+KLA	NM_023737	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (Ehhadh), mRNA [NM_023737]	KLA	.74	.77	.80	.88	.71	.67	.74
				ATP	1.02	1.06	1.04	.90	.70	.84	.83
				KLA/ATP	.79	.81	.80	.65	.59	.79	.55
Gcdh	KLA  ATP  ATP+KLA	U18992	glutaryl-CoA dehydrogenase mRNA, complete cds. [U18992]	KLA	.93	.79	.71	.83	.76	.74	.79
				ATP	1.03	1.08	1.25	1.15	.86	.56	.75
				KLA/ATP	.72	.82	1.12	.93	.68	.50	.48
Hadh	KLA  ATP  ATP+KLA	NM_008212	hydroxyacyl-Coenzyme A dehydrogenase (Hadh), nuclear gene encoding mitochondrial protein, mRNA [NM_008212]	KLA	.75	.75	.72	.64	.54	.37	.49
				ATP	1.12	1.19	1.08	1.28	.96	.43	.41
				KLA/ATP	.76	.81	.68	.85	.56	.42	.21
Hadha	KLA  ATP  ATP+KLA	AK050856	9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert	KLA	.96	.92	.91	.80	.97	.92	.90
				ATP	.72	.64	.63	.71	.91	.93	.93
				KLA/ATP	.79	.72	.68	.73	.87	.90	.88
Hadha	KLA  ATP  ATP+KLA	NM_178878	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878]	KLA	1.10	1.17	1.36	1.16	1.23	1.10	1.00
				ATP	1.16	1.22	1.03	1.40	1.09	.79	1.11
				KLA/ATP	1.33	1.35	1.16	1.41	1.00	.92	1.31
Il4i1	KLA  ATP  ATP+KLA	NM_010215	interleukin 4 induced 1 (Il4i1), mRNA [NM_010215]	KLA	13.98	13.74	14.90	14.92	13.89	12.12	3.25
				ATP	1.02	.98	1.14	1.59	4.45	6.63	2.41
				KLA/ATP	16.09	15.56	19.65	19.66	18.47	14.84	12.99
Indo	KLA  ATP  ATP+KLA	NM_008324	indoleamine-pyrrole 2,3 dioxygenase (Indo), mRNA [NM_008324]	KLA	1.56	1.62	1.87	1.73	1.52	1.38	1.28
				ATP	1.09	1.01	1.08	1.02	1.00	1.06	1.07
				KLA/ATP	1.53	1.60	1.78	1.50	1.49	1.40	3.38
Indol1	KLA  ATP  ATP+KLA	NM_145949	indoleamine-pyrrole 2,3 dioxygenase-like 1 (Indol1), mRNA [NM_145949]	KLA	2.01	2.13	2.31	2.13	2.14	2.14	2.52
				ATP	.96	.98	1.06	1.12	.99	1.18	1.25
				KLA/ATP	2.03	2.15	1.83	1.54	1.38	1.32	2.07
Inmt	KLA  ATP  ATP+KLA	NM_009349	indolethylamine N-methyltransferase (Inmt), mRNA [NM_009349]	KLA	1.93	2.09	2.34	2.04	2.49	1.90	1.81
				ATP	.97	1.13	.96	1.21	1.04	1.02	1.40
				KLA/ATP	2.00	2.00	1.37	1.91	1.41	1.31	1.62
Kmo	KLA  ATP  ATP+KLA	NM_133809	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (Kmo), mRNA [NM_133809]	KLA	2.27	2.39	2.79	2.51	2.33	1.55	.70
				ATP	.95	1.15	1.11	1.08	.94	.98	.63
				KLA/ATP	2.15	2.35	2.11	1.65	1.33	1.30	.72
Kynu	KLA  ATP  ATP+KLA	BC026950	kynureninase (L-kynurenine hydrolase), mRNA (cDNA clone MGC:30315 IMAGE:5136970), complete cds. [BC026950]	KLA	.99	1.04	1.04	1.02	1.11	1.05	.98
				ATP	1.06	1.00	1.01	1.04	1.08	.99	.97
				KLA/ATP	1.08	1.07	.95	.99	1.06	1.11	1.02
Kynu	KLA  ATP  ATP+KLA	NM_027552	kynureninase (L-kynurenine hydrolase) (Kynu), mRNA [NM_027552]	KLA	1.86	1.93	2.04	1.85	1.45	1.18	1.10
				ATP	.99	1.01	1.05	1.12	1.00	1.03	1.09
				KLA/ATP	1.84	1.75	2.04	1.63	1.46	1.26	1.27
Lao1	KLA  ATP  ATP+KLA	NM_133892	L-amino acid oxidase 1 (Lao1), mRNA [NM_133892]	KLA	1.03	1.03	1.04	1.00	.98	1.01	.98
				ATP	1.01	1.03	1.02	.92	1.05	.98	.99
				KLA/ATP	1.02	.96	1.04	.94	.96	.97	.97
Maoa	KLA  ATP  ATP+KLA	NM_173740	monoamine oxidase A (Maoa), nuclear gene encoding mitochondrial protein, mRNA [NM_173740]	KLA	1.14	1.11	1.06	1.07	.84	.55	.53
				ATP	1.10	1.07	1.33	1.20	1.44	2.37	1.38
				KLA/ATP	.97	1.11	1.75	1.33	1.27	1.21	1.09
Maob	KLA  ATP  ATP+KLA	NM_172778	monoamine oxidase B (Maob), nuclear gene encoding mitochondrial protein, mRNA [NM_172778]	KLA	1.01	.97	1.01	1.05	1.01	.95	1.01
				ATP	1.09	.98	.99	.97	1.03	1.03	.94
				KLA/ATP	1.02	1.05	.99	1.02	1.00	.98	.98
Mm.27395 8	KLA  ATP  ATP+KLA	31560783	Unknown	KLA	.84	.82	.82	.88	1.05	1.14	1.07
				ATP	1.36	1.47	1.11	1.14	1.07	.85	.81
				KLA/ATP	.97	.93	.90	1.13	1.05	.99	1.01
Mm.29323 3	KLA  ATP  ATP+KLA	118130035	Unknown	KLA	.98	1.04	.98	1.05	1.07	.97	.95
				ATP	1.02	1.04	1.01	1.02	1.00	1.00	1.00
				KLA/ATP	1.03	1.00	.98	.96	1.10	1.03	.98
Mm.31830 2	KLA  ATP  ATP+KLA	124487482	Unknown	KLA	1.02	1.02	1.02	1.06	1.03	.98	1.05
				ATP	1.00	.99	1.04	1.17	1.04	.98	.96
				KLA/ATP	1.04	1.02	1.22	1.05	.99	.99	.99
Ogdh	KLA  ATP  ATP+KLA	NM_010956	oxoglutarate dehydrogenase (lipoamide) (Ogdh), nuclear gene encoding mitochondrial protein, mRNA [NM_010956]	KLA	1.00	1.05	1.10	.95	1.06	1.08	1.30
				ATP	1.10	1.28	.95	1.23	.93	1.15	1.82
				KLA/ATP	1.27	1.11	.81	1.21	.76	1.13	1.83
Ogdhl	KLA  ATP  ATP+KLA	NM_001081130	oxoglutarate dehydrogenase-like (Ogdhl), mRNA [NM_001081130]	KLA	1.03	1.07	1.03	1.02	1.00	.97	.91
				ATP	.94	.99	.98	.99	.93	.99	1.01
				KLA/ATP	.97	1.02	1.03	.93	.95	.90	1.04
Tdo2	KLA  ATP  ATP+KLA	NM_019911	tryptophan 2,3-dioxygenase (Tdo2), mRNA [NM_019911]	KLA	.99	1.04	1.03	.98	1.08	1.01	1.02
				ATP	.98	1.01	.99	.98	1.06	1.06	1.04
				KLA/ATP	1.06	.95	1.06	1.02	1.02	1.00	.98
Tph1	KLA  ATP  ATP+KLA	NM_009414	tryptophan hydroxylase 1 (Tph1), mRNA [NM_009414]	KLA	.99	1.02	1.03	1.03	1.01	1.00	1.03
				ATP	1.07	1.04	1.01	1.02	.99	.98	.98
				KLA/ATP	1.00	1.07	1.05	1.37	1.20	1.03	.99
Tph2	KLA  ATP  ATP+KLA	AY090565	neuronal tryptophan hydroxylase (Ntph) mRNA, complete cds [AY090565]	KLA	1.01	.98	.98	1.05	.96	.97	1.05
				ATP	.94	1.04	.95	.93	.97	.91	.95
				KLA/ATP	1.06	1.07	.99	.99	1.05	1.06	.98