Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Phenylalanine metabolism (mmu00360)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
1700055N 04Rik	KLA  ATP  ATP+KLA	AK081788	16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130077J09 product:weakly similar to ALDEHYDE DEHYDROGENASE 7 (EC 1.2.1.5) [Homo sapiens], full insert sequence [AK081788]	KLA	.96	.98	.95	.97	.97	.96	1.06
				ATP	1.01	1.00	.97	1.10	.95	.99	1.02
				KLA/ATP	.99	1.00	.97	1.00	1.00	.96	.97
4930438A 08Rik	KLA  ATP  ATP+KLA	XM_001477470	gb|PREDICTED: Mus musculus RIKEN cDNA 4930438A08 gene (4930438A08Rik), mRNA [XM_001477470]	KLA	1.78	1.45	1.69	1.62	1.69	1.48	1.31
				ATP	1.07	1.04	1.24	1.13	1.13	1.61	1.67
				KLA/ATP	1.83	1.46	1.58	1.30	1.43	1.36	1.95
Aldh1a3	KLA  ATP  ATP+KLA	AK086764	15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930050B08 product:aldehyde dehydrogenase family 1, subfamily A3, full insert sequence. [AK086764]	KLA	.97	1.05	1.05	1.01	1.00	.98	.97
				ATP	1.00	1.03	.99	.92	1.01	1.09	1.02
				KLA/ATP	1.01	.99	1.06	1.00	.97	.98	1.00
Aldh1a3	KLA  ATP  ATP+KLA	NM_053080	aldehyde dehydrogenase family 1, subfamily A3 (Aldh1a3), mRNA [NM_053080]	KLA	1.03	.96	1.03	1.03	.96	.98	1.01
				ATP	.98	1.04	1.01	1.06	.98	1.01	1.08
				KLA/ATP	1.02	1.00	1.02	.94	1.03	.99	.99
Aldh3a1	KLA  ATP  ATP+KLA	NM_007436	aldehyde dehydrogenase family 3, subfamily A1 (Aldh3a1), transcript variant 1, mRNA [NM_007436]	KLA	.98	.98	1.03	1.01	1.03	1.04	.97
				ATP	.98	1.01	1.06	.95	1.00	.96	1.02
				KLA/ATP	1.07	1.08	.99	.98	1.03	.93	.98
Aldh3b1	KLA  ATP  ATP+KLA	NM_026316	aldehyde dehydrogenase 3 family, member B1 (Aldh3b1), mRNA [NM_026316]	KLA	.82	.77	.69	.77	.72	.97	1.31
				ATP	.88	.85	1.13	.89	.71	.56	1.25
				KLA/ATP	.66	.72	.84	.66	.66	.52	1.17
Aldh3b2	KLA  ATP  ATP+KLA	XM_129134	gb|PREDICTED: Mus musculus aldehyde dehydrogenase 3 family, member B2 (Aldh3b2), mRNA [XM_129134]	KLA	.91	.93	.85	.88	1.01	.99	1.37
				ATP	1.12	1.11	.99	1.19	.87	.61	1.31
				KLA/ATP	.86	1.02	.90	1.01	.72	.54	1.21
Aoc2	KLA  ATP  ATP+KLA	NM_178932	amine oxidase, copper containing 2 (retina-specific) (Aoc2), mRNA [NM_178932]	KLA	1.21	1.19	1.15	1.00	1.15	1.21	1.18
				ATP	1.13	1.13	1.14	1.36	1.85	1.32	.76
				KLA/ATP	1.27	1.34	1.12	1.32	1.67	1.37	1.05
Aoc3	KLA  ATP  ATP+KLA	NM_009675	amine oxidase, copper containing 3 (Aoc3), mRNA [NM_009675]	KLA	.95	1.06	1.00	1.05	1.00	1.02	1.01
				ATP	1.01	.90	1.04	1.07	1.06	1.06	.97
				KLA/ATP	1.06	.98	.92	1.10	1.11	1.09	1.01
Ddc	KLA  ATP  ATP+KLA	NM_016672	dopa decarboxylase (Ddc), mRNA [NM_016672]	KLA	1.27	1.28	1.34	1.33	1.34	1.21	1.05
				ATP	1.02	.99	1.05	.98	1.02	1.02	1.14
				KLA/ATP	1.24	1.22	1.28	1.25	1.12	1.20	1.35
Glyat	KLA  ATP  ATP+KLA	BC015294	glycine-N-acyltransferase, mRNA (cDNA clone MGC:19155 IMAGE:4220471), complete cds [BC015294]	KLA	1.09	1.02	.98	1.09	1.05	1.06	1.01
				ATP	1.01	1.05	1.07	1.03	1.01	1.01	1.07
				KLA/ATP	1.02	.97	1.03	.96	1.04	1.02	.99
Glyat	KLA  ATP  ATP+KLA	NM_145935	glycine-N-acyltransferase (Glyat), nuclear gene encoding mitochondrial protein, mRNA [NM_145935]	KLA	1.03	1.06	.99	1.00	.99	.98	1.11
				ATP	.99	1.00	1.00	1.27	1.18	1.11	1.10
				KLA/ATP	.97	.95	.95	1.46	1.47	1.14	1.09
Got1	KLA  ATP  ATP+KLA	NM_010324	glutamate oxaloacetate transaminase 1, soluble (Got1), mRNA [NM_010324]	KLA	.68	.70	.66	.56	.50	.57	.99
				ATP	1.01	1.24	1.55	1.59	1.47	1.03	1.68
				KLA/ATP	.68	.71	.66	.77	1.13	2.33	1.89
Got2	KLA  ATP  ATP+KLA	NM_010325	glutamate oxaloacetate transaminase 2, mitochondrial (Got2), nuclear gene encoding mitochondrial protein, mRNA [NM_010325]	KLA	.84	.86	.88	.75	.75	.63	.61
				ATP	1.02	1.12	.98	1.15	.98	.67	.86
				KLA/ATP	.92	.89	.75	.89	.68	.70	.77
Hpd	KLA  ATP  ATP+KLA	NM_008277	4-hydroxyphenylpyruvic acid dioxygenase (Hpd), mRNA [NM_008277]	KLA	.94	1.10	1.04	1.02	.97	.97	1.06
				ATP	1.05	1.07	.96	1.01	1.09	.97	1.01
				KLA/ATP	1.02	1.03	1.12	1.00	.98	1.06	1.02
Il4i1	KLA  ATP  ATP+KLA	NM_010215	interleukin 4 induced 1 (Il4i1), mRNA [NM_010215]	KLA	13.98	13.74	14.90	14.92	13.89	12.12	3.25
				ATP	1.02	.98	1.14	1.59	4.45	6.63	2.41
				KLA/ATP	16.09	15.56	19.65	19.66	18.47	14.84	12.99
Lao1	KLA  ATP  ATP+KLA	NM_133892	L-amino acid oxidase 1 (Lao1), mRNA [NM_133892]	KLA	1.03	1.03	1.04	1.00	.98	1.01	.98
				ATP	1.01	1.03	1.02	.92	1.05	.98	.99
				KLA/ATP	1.02	.96	1.04	.94	.96	.97	.97
Maoa	KLA  ATP  ATP+KLA	NM_173740	monoamine oxidase A (Maoa), nuclear gene encoding mitochondrial protein, mRNA [NM_173740]	KLA	1.14	1.11	1.06	1.07	.84	.55	.53
				ATP	1.10	1.07	1.33	1.20	1.44	2.37	1.38
				KLA/ATP	.97	1.11	1.75	1.33	1.27	1.21	1.09
Maob	KLA  ATP  ATP+KLA	NM_172778	monoamine oxidase B (Maob), nuclear gene encoding mitochondrial protein, mRNA [NM_172778]	KLA	1.01	.97	1.01	1.05	1.01	.95	1.01
				ATP	1.09	.98	.99	.97	1.03	1.03	.94
				KLA/ATP	1.02	1.05	.99	1.02	1.00	.98	.98
Mif	KLA  ATP  ATP+KLA	NM_010798	macrophage migration inhibitory factor (Mif), mRNA [NM_010798]	KLA	.91	1.04	1.03	.89	1.01	.87	1.06
				ATP	1.10	1.26	.98	1.34	1.22	1.11	.92
				KLA/ATP	1.06	1.15	.85	1.30	1.09	1.17	1.08
Mm.26684 3	KLA  ATP  ATP+KLA	94405693	Unknown	KLA	1.12	.99	.99	1.00	.97	.98	.96
				ATP	1.02	1.08	1.01	.90	1.02	.97	.91
				KLA/ATP	1.03	.96	.98	.91	1.05	.90	.97
Mm.34137	KLA  ATP  ATP+KLA	94405716	Unknown	KLA	1.11	1.12	1.10	1.07	1.08	1.13	1.36
				ATP	1.09	1.14	1.01	1.25	.95	.79	1.23
				KLA/ATP	1.01	1.24	.95	1.14	.83	.78	1.30
Pah	KLA  ATP  ATP+KLA	NM_008777	phenylalanine hydroxylase (Pah), mRNA [NM_008777]	KLA	.99	.93	1.06	.99	1.01	.99	.98
				ATP	1.09	1.02	.99	.95	.97	.98	.99
				KLA/ATP	.97	.93	.97	.95	.95	1.00	.87
Prdx6	KLA  ATP  ATP+KLA	AK081980	16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130091B17 product:peroxiredoxin 5, related sequence 3, full insert sequence [AK081980]	KLA	1.61	1.58	.92	.93	.93	1.08	1.24
				ATP	2.61	2.91	4.18	6.45	12.41	12.74	3.19
				KLA/ATP	2.79	4.31	7.52	6.17	5.64	6.93	5.25
Prdx6	KLA  ATP  ATP+KLA	NM_007453	peroxiredoxin 6 (Prdx6), mRNA [NM_007453]	KLA	1.33	1.40	1.49	1.32	1.28	1.04	.90
				ATP	1.07	1.22	1.15	1.46	2.77	9.93	8.48
				KLA/ATP	1.36	1.59	1.61	1.96	1.90	5.10	9.06
Tat	KLA  ATP  ATP+KLA	NM_146214	tyrosine aminotransferase (Tat), nuclear gene encoding mitochondrial protein, mRNA [NM_146214]	KLA	1.13	1.09	1.19	1.17	1.14	1.19	1.10
				ATP	.97	1.08	1.12	1.25	1.02	1.16	1.18
				KLA/ATP	1.16	1.21	1.27	1.23	1.22	1.11	1.08