Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

Search by fold change ratio | Search by KEGG pathway | Search by LIPID MAPS lipid pathway

Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Fatty acid elongation (mmu00062)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Acaa2
KLA  ATP  ATP+KLA
 NM_177470 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) (Acaa2), nuclear gene encoding mitochondrial protein, mRNA [NM_177470] KLA .98 .94 1.00 1.00 .90 .81 .60
ATP 1.03 1.00 1.12 1.10 .84 .48 .50
KLA/ATP .98 .98 1.03 1.05 .99 .85 .40
Acot1
KLA  ATP  ATP+KLA
 NM_012006 acyl-CoA thioesterase 1 (Acot1), mRNA [NM_012006] KLA .40 .34 .32 .29 .23 .17 .16
ATP 1.01 .95 1.14 1.10 .64 .26 .53
KLA/ATP .37 .37 .42 .42 .32 .20 .22
Acot2
KLA  ATP  ATP+KLA
 NM_134188 acyl-CoA thioesterase 2 (Acot2), nuclear gene encoding mitochondrial protein, mRNA [NM_134188] KLA .46 .49 .37 .43 .34 .37 .53
ATP 1.02 1.15 .87 .99 .54 .37 .96
KLA/ATP .51 .46 .44 .49 .36 .34 .49
Acot3
KLA  ATP  ATP+KLA
 NM_134246 acyl-CoA thioesterase 3 (Acot3), mRNA [NM_134246] KLA .95 .95 1.04 .99 1.01 .97 .98
ATP 1.03 .97 1.01 .92 1.02 .99 .99
KLA/ATP .98 1.00 1.07 .96 1.01 1.00 1.01
Acot4
KLA  ATP  ATP+KLA
 NM_134247 acyl-CoA thioesterase 4 (Acot4), mRNA [NM_134247] KLA .77 .77 .72 .74 .68 .81 .85
ATP .95 .96 .97 .83 .79 .84 .99
KLA/ATP .79 .78 .76 .75 .76 .76 .84
Acot5
KLA  ATP  ATP+KLA
 NM_145444 acyl-CoA thioesterase 5 (Acot5), mRNA [NM_145444] KLA 1.03 1.07 1.00 1.02 1.05 1.06 1.07
ATP .99 .97 1.06 1.05 1.00 1.01 1.06
KLA/ATP .98 .96 1.07 1.09 1.08 1.00 1.01
Acot7
KLA  ATP  ATP+KLA
 NM_133348 acyl-CoA thioesterase 7 (Acot7), mRNA [NM_133348] KLA 1.60 1.80 1.91 1.81 1.85 1.55 1.30
ATP .99 1.08 1.07 1.46 1.32 1.25 .99
KLA/ATP 1.81 1.84 1.79 2.42 2.08 1.68 .82
Echs1
KLA  ATP  ATP+KLA
 NM_053119 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (Echs1), nuclear gene encoding mitochondrial protein, mRNA [NM_053119] KLA .57 .55 .52 .54 .60 .82 .90
ATP .99 .97 1.07 1.15 .77 .37 .81
KLA/ATP .55 .56 .55 .66 .53 .39 .41
Elovl1
KLA  ATP  ATP+KLA
 NM_001039176 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 (Elovl1), transcript variant 1, mRNA [NM_001039176] KLA .78 .77 .71 .70 .85 1.03 1.15
ATP 1.02 1.04 .85 .90 1.14 1.20 1.35
KLA/ATP .80 .80 .62 .64 .88 .99 1.03
Elovl2
KLA  ATP  ATP+KLA
 NM_019423 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2), mRNA [NM_019423] KLA 1.12 1.08 1.23 1.23 1.42 1.38 1.15
ATP .89 .96 1.06 1.01 1.10 1.49 1.16
KLA/ATP 1.06 1.21 1.14 1.21 1.44 2.32 1.68
Elovl3
KLA  ATP  ATP+KLA
 NM_007703 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 (Elovl3), mRNA [NM_007703] KLA .98 .95 .92 .98 .95 .96 1.02
ATP .97 .96 .98 .94 .97 .91 1.01
KLA/ATP 1.03 .96 .93 .86 .90 1.00 .95
Elovl4
KLA  ATP  ATP+KLA
 NM_148941 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 (Elovl4), mRNA [NM_148941] KLA 1.12 1.02 .98 1.02 1.03 1.05 .93
ATP 1.04 1.04 1.09 .99 1.02 1.11 1.07
KLA/ATP 1.07 .90 1.03 1.05 .93 .98 1.03
Elovl5
KLA  ATP  ATP+KLA
 NM_134255 ELOVL family member 5, elongation of long chain fatty acids (yeast) (Elovl5), mRNA [NM_134255] KLA .77 .76 .78 .60 .51 .48 .65
ATP .96 .98 1.17 1.29 .91 .54 .70
KLA/ATP .75 .76 .83 .79 .62 .46 .43
Elovl6
KLA  ATP  ATP+KLA
 NM_130450 ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA [NM_130450] KLA .40 .35 .30 .23 .19 .18 .23
ATP .94 .86 1.19 .77 .43 .35 .44
KLA/ATP .38 .35 .39 .34 .34 .20 .15
Elovl7
KLA  ATP  ATP+KLA
 AK137668 adult female vagina cDNA, RIKEN full-length enriched library, clone:9930019E07 product:Weakly similar to elongation of very long chain fatty acids protein 1, full insert sequence [AK137668] KLA .78 .76 .79 .81 .71 .70 .65
ATP .98 .88 1.02 .91 .81 .73 .73
KLA/ATP .74 .80 .82 .73 .78 .72 .62
Elovl7
KLA  ATP  ATP+KLA
 NM_029001 ELOVL family member 7, elongation of long chain fatty acids (yeast) (Elovl7), mRNA [NM_029001] KLA .72 .71 .70 .69 .52 .46 .35
ATP 1.03 1.01 1.13 .97 .87 .81 .87
KLA/ATP .71 .75 .82 .73 .71 .57 .53
Hadh
KLA  ATP  ATP+KLA
 NM_008212 hydroxyacyl-Coenzyme A dehydrogenase (Hadh), nuclear gene encoding mitochondrial protein, mRNA [NM_008212] KLA .75 .75 .72 .64 .54 .37 .49
ATP 1.12 1.19 1.08 1.28 .96 .43 .41
KLA/ATP .76 .81 .68 .85 .56 .42 .21
Hadha
KLA  ATP  ATP+KLA
 AK050856 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA .96 .92 .91 .80 .97 .92 .90
ATP .72 .64 .63 .71 .91 .93 .93
KLA/ATP .79 .72 .68 .73 .87 .90 .88
Hadha
KLA  ATP  ATP+KLA
 NM_178878 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA 1.10 1.17 1.36 1.16 1.23 1.10 1.00
ATP 1.16 1.22 1.03 1.40 1.09 .79 1.11
KLA/ATP 1.33 1.35 1.16 1.41 1.00 .92 1.31
Hadhb
KLA  ATP  ATP+KLA
 NM_145558 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit (Hadhb), nuclear gene encoding mitochondrial protein, mRNA [NM_145558] KLA .85 .88 .76 .77 .70 .54 .58
ATP 1.08 1.13 1.05 1.01 .84 .53 .58
KLA/ATP .79 .91 .83 .80 .61 .46 .44
Hsd17b12
KLA  ATP  ATP+KLA
 AK076088 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810004A21 product:hydroxysteroid (17-beta) dehydrogenase 12, full insert sequence. [AK076088] KLA 1.03 .87 .97 1.11 1.17 1.00 1.15
ATP 1.03 1.11 1.81 1.27 1.57 1.18 1.14
KLA/ATP 1.00 .90 1.26 .97 1.03 .97 .98
Hsd17b12
KLA  ATP  ATP+KLA
 NM_019657 hydroxysteroid (17-beta) dehydrogenase 12 (Hsd17b12), mRNA [NM_019657] KLA 1.12 1.30 1.47 1.16 1.07 1.34 1.20
ATP 1.01 1.28 1.28 1.14 1.06 1.05 .93
KLA/ATP 1.21 1.44 1.63 1.51 .91 .81 .87
Mecr
KLA  ATP  ATP+KLA
 NM_025297 mitochondrial trans-2-enoyl-CoA reductase (Mecr), nuclear gene encoding mitochondrial protein, mRNA [NM_025297] KLA 1.48 1.62 1.63 1.35 1.44 1.23 1.16
ATP 1.00 1.28 .97 1.45 1.09 .62 .55
KLA/ATP 1.77 1.77 1.16 2.13 1.26 1.00 .49
Mm.1978
KLA  ATP  ATP+KLA
 118129966 Unknown KLA .41 .34 .33 .29 .20 .17 .15
ATP 1.01 .98 1.28 1.12 .67 .28 .49
KLA/ATP .35 .38 .45 .37 .33 .22 .20
Mm.31411
3
KLA  ATP  ATP+KLA
 91598889 Unknown KLA .40 .36 .31 .30 .23 .18 .26
ATP 1.02 .86 1.23 .79 .49 .38 .44
KLA/ATP .42 .38 .47 .37 .33 .25 .16
Ppt1
KLA  ATP  ATP+KLA
 AK148314 B16 F10Y cells cDNA, RIKEN full-length enriched library, clone:G370087F11 product:palmitoyl-protein thioesterase 1, full insert sequence. [AK148314] KLA .81 .79 .79 .90 .82 .88 1.24
ATP .98 1.11 1.72 1.24 1.13 .95 1.91
KLA/ATP .80 .85 1.14 .98 .93 .73 1.39
Ppt1
KLA  ATP  ATP+KLA
 NM_008917 palmitoyl-protein thioesterase 1 (Ppt1), mRNA [NM_008917] KLA .88 .86 .86 .89 .78 .73 .81
ATP 1.05 1.02 1.17 1.10 .99 .76 .77
KLA/ATP .83 .85 1.02 .91 .71 .59 .71
Ppt2
KLA  ATP  ATP+KLA
 NM_019441 palmitoyl-protein thioesterase 2 (Ppt2), mRNA [NM_019441] KLA 1.08 1.27 1.22 1.04 1.29 1.14 1.70
ATP 1.13 1.21 .63 .82 .60 .74 1.42
KLA/ATP 1.42 1.32 .63 1.02 .54 .85 2.24
Ptplb
KLA  ATP  ATP+KLA
 AF169286 protein tyrosine phosphatase-like protein PTPLB (Ptplb) mRNA, complete cds. [AF169286] KLA 1.47 1.72 1.47 1.36 1.23 .75 .81
ATP .97 .98 .98 1.16 1.25 1.00 .66
KLA/ATP 1.48 1.64 1.69 1.76 1.61 1.19 .68
Ptplb
KLA  ATP  ATP+KLA
 NM_023587 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b (Ptplb), mRNA [NM_023587] KLA 1.28 1.38 1.30 1.29 1.10 .93 .79
ATP 1.00 1.08 1.14 1.15 .95 .82 .57
KLA/ATP 1.40 1.41 1.20 1.23 1.10 .88 .60
Tecr
KLA  ATP  ATP+KLA
 NM_134118 trans-2,3-enoyl-CoA reductase KLA .83 .95 .97 .79 .84 .77 .75
ATP 1.20 1.35 .82 1.40 1.07 .73 .70
KLA/ATP 1.19 .99 .64 1.28 .69 .69 .59