Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Citrate cycle (TCA cycle) (mmu00020)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
1500032O 14Rik	KLA  ATP  ATP+KLA	AK005350	adult male cerebellum cDNA, RIKEN full-length enriched library, clone:1500032O14 product:succinate dehydrogenase complex, subunit A, flavoprotein (Fp), full insert sequence. [AK005350]	KLA	1.01	.97	.97	.98	1.01	1.05	1.04
				ATP	.61	.42	.41	.55	1.05	1.12	.96
				KLA/ATP	.62	.53	.54	.68	1.10	1.02	.88
4933405O 20Rik	KLA  ATP  ATP+KLA	NM_172901	RIKEN cDNA 4933405O20 gene (4933405O20Rik), mRNA [NM_172901]	KLA	.98	.99	1.01	1.07	1.03	1.01	1.03
				ATP	.95	.97	.99	.96	.99	1.01	1.02
				KLA/ATP	.93	1.01	.99	.98	.98	.92	.96
AK031343	KLA  ATP  ATP+KLA	AK031343	13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030410A06 product:unclassifiable, full insert sequence [AK031343]	KLA	1.03	.97	.92	1.01	.97	.90	.94
				ATP	1.00	1.00	.92	.95	.97	.99	.98
				KLA/ATP	.98	1.01	.86	.99	.91	.93	1.00
Acly	KLA  ATP  ATP+KLA	AK043466	7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730098H14 product:unclassifiable, full insert sequence. [AK043466]	KLA	.99	.97	.93	.93	.97	.98	.94
				ATP	1.01	1.00	.93	.98	1.00	.95	1.00
				KLA/ATP	.99	1.01	.91	.94	.97	.95	1.02
Acly	KLA  ATP  ATP+KLA	NM_134037	ATP citrate lyase (Acly), mRNA [NM_134037]	KLA	1.03	1.18	1.07	.98	.99	.92	.97
				ATP	1.04	1.26	1.05	1.29	.98	.91	1.07
				KLA/ATP	1.19	1.12	.98	1.46	.88	.94	.81
Aco1	KLA  ATP  ATP+KLA	NM_007386	aconitase 1 (Aco1), mRNA [NM_007386]	KLA	.82	.85	.80	.78	.73	.74	.84
				ATP	1.02	1.07	1.04	.96	.95	.88	.83
				KLA/ATP	.83	.86	.81	.80	.76	.73	.62
Aco2	KLA  ATP  ATP+KLA	AK029122	10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732494K09 product:hypothetical protein, full insert sequence [AK029122]	KLA	1.02	1.02	.99	.98	.97	1.04	.83
				ATP	.98	1.04	1.05	.95	.95	1.02	1.00
				KLA/ATP	.96	.95	1.00	1.04	1.06	1.03	.99
Aco2	KLA  ATP  ATP+KLA	NM_080633	aconitase 2, mitochondrial (Aco2), nuclear gene encoding mitochondrial protein, mRNA [NM_080633]	KLA	.93	.96	.97	.91	.97	.99	1.07
				ATP	1.05	1.04	.98	.92	.90	.83	.99
				KLA/ATP	1.01	1.06	.86	.89	.83	.93	.93
Cs	KLA  ATP  ATP+KLA	NM_026444	citrate synthase (Cs), nuclear gene encoding mitochondrial protein, mRNA [NM_026444]	KLA	1.09	1.07	1.04	1.05	1.08	1.15	1.14
				ATP	.91	.93	1.02	.90	.90	1.08	1.38
				KLA/ATP	.99	1.04	1.09	.98	.98	.90	1.13
Csl	KLA  ATP  ATP+KLA	NM_027945	citrate synthase like (Csl), mRNA [NM_027945]	KLA	1.41	1.32	1.35	1.51	1.61	1.39	1.58
				ATP	1.17	1.15	.98	1.23	1.18	1.33	2.00
				KLA/ATP	1.32	1.53	1.45	1.59	1.13	1.14	1.77
Dlat	KLA  ATP  ATP+KLA	NM_145614	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat), mRNA [NM_145614]	KLA	1.00	1.05	1.03	.95	.87	.83	1.15
				ATP	.94	1.01	1.22	1.09	.80	.57	.91
				KLA/ATP	.96	1.01	1.05	.98	.70	.48	.54
Dld	KLA  ATP  ATP+KLA	NM_007861	dihydrolipoamide dehydrogenase (Dld), mRNA [NM_007861]	KLA	1.60	1.66	1.84	1.66	1.47	1.16	1.17
				ATP	1.05	1.08	1.21	1.06	1.15	1.24	.93
				KLA/ATP	1.52	1.63	1.65	1.42	1.17	1.05	.79
Dld	KLA  ATP  ATP+KLA	U73445	dihydrolipoamide dehydrogenase (Dld) mRNA, complete cds. [U73445]	KLA	1.48	1.43	1.43	1.47	1.25	1.05	1.16
				ATP	.94	.93	1.18	.86	1.02	1.46	.97
				KLA/ATP	1.39	1.37	1.50	1.10	1.11	1.14	.85
Dlst	KLA  ATP  ATP+KLA	AK171100	NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630223O05 product:dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), full insert sequence [AK171100]	KLA	.90	.87	.88	.83	1.10	.86	1.09
				ATP	.97	.78	.47	.80	2.22	1.46	1.21
				KLA/ATP	1.00	.91	.66	.76	1.24	1.06	1.04
Dlst	KLA  ATP  ATP+KLA	NM_030225	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (Dlst), mRNA [NM_030225]	KLA	1.15	1.22	1.20	1.11	1.02	.97	1.13
				ATP	1.02	1.01	1.02	.95	1.01	1.36	1.19
				KLA/ATP	1.23	1.29	1.23	1.19	.99	.98	.99
Fh1	KLA  ATP  ATP+KLA	NM_010209	fumarate hydratase 1 (Fh1), mRNA [NM_010209]	KLA	1.00	.88	.79	.83	.55	.36	.39
				ATP	1.05	1.05	1.08	.98	.89	.49	.45
				KLA/ATP	.91	.95	1.06	.92	.72	.41	.18
Idh1	KLA  ATP  ATP+KLA	NM_010497	isocitrate dehydrogenase 1 (NADP+), soluble (Idh1), transcript variant 2, mRNA [NM_010497]	KLA	.71	.74	.69	.70	.54	.45	.63
				ATP	1.22	1.28	1.00	1.28	1.06	.62	.81
				KLA/ATP	.76	.81	.68	.88	.55	.47	.40
Idh2	KLA  ATP  ATP+KLA	NM_173011	isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2), nuclear gene encoding mitochondrial protein, mRNA [NM_173011]	KLA	.83	.83	.88	.94	.66	.31	.38
				ATP	1.04	1.09	1.14	1.48	1.26	.39	.49
				KLA/ATP	.90	.92	1.04	1.10	.82	.41	.20
Idh3a	KLA  ATP  ATP+KLA	NM_029573	isocitrate dehydrogenase 3 (NAD+) alpha (Idh3a), nuclear gene encoding mitochondrial protein, mRNA [NM_029573]	KLA	.99	1.06	.85	.83	.67	.51	.73
				ATP	.95	1.07	1.12	1.22	.93	.46	.52
				KLA/ATP	.92	1.00	.91	1.12	.75	.42	.21
Idh3b	KLA  ATP  ATP+KLA	NM_130884	isocitrate dehydrogenase 3 (NAD+) beta (Idh3b), nuclear gene encoding mitochondrial protein, mRNA [NM_130884]	KLA	.89	.94	.94	.89	.97	1.00	1.12
				ATP	1.01	1.07	.94	1.16	.94	.52	.68
				KLA/ATP	.92	.94	.78	1.05	.78	.73	.58
Idh3g	KLA  ATP  ATP+KLA	NM_008323	isocitrate dehydrogenase 3 (NAD+), gamma (Idh3g), nuclear gene encoding mitochondrial protein, mRNA [NM_008323]	KLA	.74	.69	.66	.68	.61	.55	.63
				ATP	.94	.91	1.06	1.09	.93	.66	.62
				KLA/ATP	.72	.74	.80	.80	.73	.56	.48
Mdh1	KLA  ATP  ATP+KLA	AK077724	8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730556L21 product:unclassifiable, full insert sequence [AK077724]	KLA	.85	.75	.69	.67	.72	.81	.82
				ATP	.93	.83	.61	.59	.72	.72	.88
				KLA/ATP	.79	.76	.67	.58	.74	.74	.80
Mdh1	KLA  ATP  ATP+KLA	NM_008618	malate dehydrogenase 1, NAD (soluble) (Mdh1), mRNA [NM_008618]	KLA	.79	.72	.66	.66	.52	.49	.57
				ATP	.98	1.00	1.17	1.09	.96	.70	.66
				KLA/ATP	.70	.73	.92	.78	.76	.65	.52
Mdh2	KLA  ATP  ATP+KLA	NM_008617	malate dehydrogenase 2, NAD (mitochondrial) (Mdh2), nuclear gene encoding mitochondrial protein, mRNA [NM_008617]	KLA	.90	.91	.81	.86	.81	.91	1.26
				ATP	.96	.86	1.04	.80	1.01	1.36	1.33
				KLA/ATP	.87	.79	1.04	.71	.95	1.04	.95
Mm.1845	KLA  ATP  ATP+KLA	142351600	Unknown	KLA	.93	.92	.89	.81	.76	.84	.65
				ATP	1.01	.94	1.08	1.00	.77	1.95	1.13
				KLA/ATP	.91	.84	.85	.81	.59	.66	.77
Mm.31830 2	KLA  ATP  ATP+KLA	124487482	Unknown	KLA	1.02	1.02	1.02	1.06	1.03	.98	1.05
				ATP	1.00	.99	1.04	1.17	1.04	.98	.96
				KLA/ATP	1.04	1.02	1.22	1.05	.99	.99	.99
Ogdh	KLA  ATP  ATP+KLA	NM_010956	oxoglutarate dehydrogenase (lipoamide) (Ogdh), nuclear gene encoding mitochondrial protein, mRNA [NM_010956]	KLA	1.00	1.05	1.10	.95	1.06	1.08	1.30
				ATP	1.10	1.28	.95	1.23	.93	1.15	1.82
				KLA/ATP	1.27	1.11	.81	1.21	.76	1.13	1.83
Ogdhl	KLA  ATP  ATP+KLA	NM_001081130	oxoglutarate dehydrogenase-like (Ogdhl), mRNA [NM_001081130]	KLA	1.03	1.07	1.03	1.02	1.00	.97	.91
				ATP	.94	.99	.98	.99	.93	.99	1.01
				KLA/ATP	.97	1.02	1.03	.93	.95	.90	1.04
Pck2	KLA  ATP  ATP+KLA	NM_028994	phosphoenolpyruvate carboxykinase 2 (mitochondrial) (Pck2), nuclear gene encoding mitochondrial protein, mRNA [NM_028994]	KLA	.40	.37	.32	.28	.37	.56	.55
				ATP	.99	.96	.86	.94	1.02	.57	.77
				KLA/ATP	.40	.37	.31	.35	.42	.35	.46
Pcx	KLA  ATP  ATP+KLA	NM_008797	pyruvate carboxylase (Pcx), nuclear gene encoding mitochondrial protein, mRNA [NM_008797]	KLA	1.28	1.34	1.44	1.30	1.34	1.23	.91
				ATP	1.11	1.09	1.19	1.29	1.19	1.49	1.16
				KLA/ATP	1.34	1.41	1.63	1.53	1.39	1.05	1.15
Pdha1	KLA  ATP  ATP+KLA	NM_008810	pyruvate dehydrogenase E1 alpha 1 (Pdha1), nuclear gene encoding mitochondrial protein, mRNA [NM_008810]	KLA	.92	.96	.94	.92	.94	1.04	1.18
				ATP	.98	1.03	1.14	1.10	1.02	1.05	.91
				KLA/ATP	.93	.93	.97	.94	.81	.82	.69
Pdha2	KLA  ATP  ATP+KLA	NM_008811	pyruvate dehydrogenase E1 alpha 2 (Pdha2), mRNA [NM_008811]	KLA	1.04	.95	.98	.99	1.00	1.04	.98
				ATP	1.00	.97	.95	1.00	1.01	.99	1.01
				KLA/ATP	1.05	1.07	.91	1.02	.98	1.00	1.05
Pdhb	KLA  ATP  ATP+KLA	NM_024221	pyruvate dehydrogenase (lipoamide) beta (Pdhb), mRNA [NM_024221]	KLA	1.14	1.05	1.00	.97	1.03	.90	.88
				ATP	1.08	1.10	1.12	1.23	1.24	1.24	1.21
				KLA/ATP	1.01	1.16	1.13	1.21	1.23	1.44	1.26
Pdhx	KLA  ATP  ATP+KLA	NM_175094	pyruvate dehydrogenase complex, component X (Pdhx), nuclear gene encoding mitochondrial protein, mRNA [NM_175094]	KLA	1.15	1.12	1.12	1.12	1.07	1.14	1.12
				ATP	1.04	1.02	1.14	.94	1.03	1.30	.98
				KLA/ATP	1.25	1.20	1.26	1.05	1.08	1.38	.89
Sdha	KLA  ATP  ATP+KLA	NM_023281	succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (Sdha), nuclear gene encoding mitochondrial protein, mRNA [NM_023281]	KLA	.97	1.04	1.13	.96	.99	.90	1.09
				ATP	1.09	1.20	.93	1.16	.88	.55	.94
				KLA/ATP	1.12	1.16	.82	1.02	.65	.65	.78
Sdhb	KLA  ATP  ATP+KLA	NM_023374	succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb), mRNA [NM_023374]	KLA	.83	.83	.84	.90	.88	1.22	1.74
				ATP	1.08	1.02	1.04	1.19	1.05	.63	.87
				KLA/ATP	.86	.84	.89	.89	.95	.94	.95
Sdhc	KLA  ATP  ATP+KLA	NM_025321	succinate dehydrogenase complex, subunit C, integral membrane protein (Sdhc), nuclear gene encoding mitochondrial protein, mRNA [NM_025321]	KLA	.90	.95	1.00	.93	.95	.84	1.01
				ATP	1.19	1.21	.98	1.38	1.06	.58	.88
				KLA/ATP	1.07	1.18	.93	1.11	.90	.80	.75
Sdhd	KLA  ATP  ATP+KLA	NM_025848	succinate dehydrogenase complex, subunit D, integral membrane protein (Sdhd), nuclear gene encoding mitochondrial protein, mRNA [NM_025848]	KLA	.94	.92	.93	.92	.93	.92	1.07
				ATP	.98	1.02	1.05	1.16	.96	.91	.94
				KLA/ATP	.90	.98	.91	1.01	.94	1.06	1.01
Sucla2	KLA  ATP  ATP+KLA	AK016060	adult male testis cDNA, RIKEN full-length enriched library, clone:4930547K18 product:unclassifiable, full insert sequence. [AK016060]	KLA	.92	1.07	.96	1.02	.97	.95	1.02
				ATP	1.08	1.02	1.00	1.06	.92	1.01	.94
				KLA/ATP	.94	1.04	1.04	.96	.94	.94	.90
Sucla2	KLA  ATP  ATP+KLA	NM_011506	succinate-Coenzyme A ligase, ADP-forming, beta subunit (Sucla2), nuclear gene encoding mitochondrial protein, mRNA [NM_011506]	KLA	1.10	1.02	1.00	1.06	.87	.81	.86
				ATP	.98	.95	1.30	1.02	.93	.69	.72
				KLA/ATP	.98	1.02	1.35	1.04	1.00	.61	.52
Suclg1	KLA  ATP  ATP+KLA	NM_019879	succinate-CoA ligase, GDP-forming, alpha subunit (Suclg1), mRNA [NM_019879]	KLA	.87	.88	.81	.81	.84	.79	.89
				ATP	1.14	1.06	1.05	1.06	.87	.41	.81
				KLA/ATP	.93	.92	.92	.92	.76	.49	.49
Suclg2	KLA  ATP  ATP+KLA	NM_011507	succinate-Coenzyme A ligase, GDP-forming, beta subunit (Suclg2), mRNA [NM_011507]	KLA	.99	1.07	1.08	.88	.74	.49	.67
				ATP	1.00	1.14	1.15	1.44	.91	.37	.45
				KLA/ATP	1.08	1.08	.94	1.18	.65	.40	.35